Next-Generation Sequencing and Result Interpretation in Clinical Oncology: Challenges of Personalized Cancer Therapy

2017 ◽  
Vol 68 (1) ◽  
pp. 113-125 ◽  
Author(s):  
Yekaterina B. Khotskaya ◽  
Gordon B. Mills ◽  
Kenna R. Mills Shaw
Keyword(s):  
Next Generation Sequencing ◽  
Cancer Therapy ◽  
Clinical Oncology ◽  
Next Generation ◽  
Personalized Cancer Therapy ◽  
Personalized Cancer ◽  
Result Interpretation ◽  
Generation Sequencing

The applications of next-generation sequencing (NGS) in drug development for cancer therapy

2020 ◽  
Vol 16 ◽  
Author(s):  
Pelin Telkoparan-Akillilar ◽  
Dilek Cevik
Keyword(s):  
Next Generation Sequencing ◽  
Drug Discovery ◽  
Cancer Therapy ◽  
Target Identification ◽  
Rapid Development ◽  
Next Generation ◽  
Biomedical Sciences ◽  
Dna And Rna ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Background: Numerous sequencing techniques have been progressed since the 1960s with the rapid development of molecular biology studies focusing on DNA and RNA. Methods: a great number of articles, book chapters, websites are reviewed, and the studies covering NGS history, technology and applications to cancer therapy are included in the present article. Results: High throughput next-generation sequencing (NGS) technologies offer many advantages over classical Sanger sequencing with decreasing cost per base and increasing sequencing efficiency. NGS technologies are combined with bioinformatics software to sequence genomes to be used in diagnostics, transcriptomics, epidemiologic and clinical trials in biomedical sciences. The NGS technology has also been successfully used in drug discovery for the treatment of different cancer types. Conclusion: This review focuses on current and potential applications of NGS in various stages of drug discovery process, from target identification through to personalized medicine.

scholarly journals Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Maxim Ivanov ◽  
Konstantin Laktionov ◽  
Valery Breder ◽  
Polina Chernenko ◽  
Ekaterina Novikova ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Clinical Oncology ◽  
Next Generation ◽  
Ffpe Samples ◽  
Generation Sequencing

Design of targeted, capture-based, next generation sequencing tests for precision cancer therapy

2013 ◽  
Vol 206 (12) ◽  
pp. 420-431 ◽  
Author(s):  
Ian S. Hagemann ◽  
Catherine E. Cottrell ◽  
Christina M. Lockwood
Keyword(s):  
Next Generation Sequencing ◽  
Cancer Therapy ◽  
Next Generation ◽  
Targeted Capture ◽  
Generation Sequencing

scholarly journals Tissue recommendations for precision cancer therapy using next generation sequencing: a comprehensive single cancer center’s experiences

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 42478-42486 ◽  
Author(s):  
Minho Cho ◽  
Soomin Ahn ◽  
Mineui Hong ◽  
Heejin Bang ◽  
Michael Van Vrancken ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Cancer Therapy ◽  
Next Generation ◽  
Single Cancer ◽  
Generation Sequencing

scholarly journals Next-Generation Sequencing: A Critical Review of Its Applications in Clinical Microbiology

2020 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Shuaibu Abdullahi Hudu ◽  
Saadatu Haruna Shinkafi ◽  
Shuaibu Umar ◽  
Babazhitsu Makun ◽  
Khadijah Muhammad Dada
Keyword(s):  
Public Health ◽  
Next Generation Sequencing ◽  
Clinical Microbiology ◽  
Diagnostic Procedures ◽  
Distinct Advantage ◽  
Next Generation ◽  
Genomic Changes ◽  
Diagnostic Microbiology ◽  
Personalized Cancer ◽  
Generation Sequencing

Next-generation sequencing (NGS) technology is fast supplementing and improving the current conventional sequencing. This is as a result of its ability to sequence pathogen genomes and interpret the information in near real-time. The aim of this paper is to review the applications of next-generation sequencing in clinical microbiology. With the speedy advances in NGS innovations, clinical and public health microbiology labs are progressively accepting NGS innovation in their workflows into their diagnostic procedures. In this review, it has been found that the applications of NGS in the clinical and public health microbiology settings are not disposable, and have the potential to guide clinicians in tailoring treatment to dynamic genomic changes of microbes. Next-generation sequencing has opened a broad new area of research with the potential to revolutionize personalized cancer medicine. Advances in NGS have demonstrated a distinct advantage in diagnostic microbiology, fundamentally lessening the time from diagnosis to clinical treatment.

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