Acetylcholine Binding Protein (AChBP): A Secreted Glial Protein That Provides a High-Resolution Model for the Extracellular Domain of Pentameric Ligand-Gated Ion Channels

2003 ◽  
Vol 32 (1) ◽  
pp. 311-334 ◽  
Author(s):  
Titia K. Sixma ◽  
August B. Smit
Keyword(s):  
Ion Channels ◽  
High Resolution ◽  
Binding Protein ◽  
Extracellular Domain ◽  
Acetylcholine Binding Protein ◽  
Resolution Model ◽  
High Resolution Model ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels

Ligand-gated ion channels as targets of neuroactive insecticides

2021 ◽  
Author(s):  
Makoto Ihara
Keyword(s):  
Ion Channels ◽  
Molecular Mechanisms ◽  
Functional Expression ◽  
X Ray ◽  
Acetylcholine Binding Protein ◽  
Site Selectivity ◽  
Future Drug ◽  
Cl Channels ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels

Abstract The Cys-loop superfamily of ligand-gated ion channels (Cys-loop receptors) is one of the most ubiquitous ion channel families in vertebrates and invertebrates. Despite their ubiquity, they are targeted by several classes of pesticides, including neonicotinoids, phenylpyrazols, and macrolides such as ivermectins. The current commercialized compounds have high target site selectivity, which contributes to the safety of insecticide use. Structural analyses have accelerated progress in this field; notably, the X-ray crystal structures of acetylcholine binding protein and glutamate-gated Cl channels revealed the details of the molecular interactions between insecticides and their targets. Recently, the functional expression of the insect nicotinic acetylcholine receptor (nAChR) has been described, and detailed evaluations using the insect nAChR have emerged. This review discusses the basic concepts and the current insights into the molecular mechanisms of neuroactive insecticides targeting the ligand-gated ion channels, particularly Cys-loop receptors, and presents insights into target-based selectivity, resistance, and future drug design.

scholarly journals Representativity error for temperature and humidity using the Met Office high‐resolution model†

2013 ◽  
Vol 140 (681) ◽  
pp. 1189-1197 ◽  
Author(s):  
J. A. Waller ◽  
S. L. Dance ◽  
A. S. Lawless ◽  
N. K. Nichols ◽  
J. R. Eyre
Keyword(s):  
High Resolution ◽  
Temperature And Humidity ◽  
Resolution Model ◽  
High Resolution Model

A high-resolution model of the inner organs based on the visible muman data set

2002 ◽  
Vol 5 (3) ◽  
pp. 212-212 ◽  
Author(s):  
U. Tiede ◽  
A. Pommert ◽  
B. Pflesser ◽  
E. Richter ◽  
M. Riemer ◽  
...  
Keyword(s):  
High Resolution ◽  
Data Set ◽  
Inner Organs ◽  
Resolution Model ◽  
High Resolution Model
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