Roentgen Therapy of Primary Neoplasms of the Brain

✓ A 69-year-old man had two different primary neoplasms of the central nervous system and a third primary malignant neoplasm of the large bowel. Similarities and differences between this case and cases previously reported are discussed.

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Trigeminal Ophthalmic Branch Schwannoma: Case Report and Literature Review

Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery ◽

10.1055/s-0040-1718421 ◽

2020 ◽

Author(s):

Luiza Rech Köhler ◽

Paulo Moacir Mesquita Filho ◽

Fabio Pires Santos ◽

Renato Sawasaki ◽

Richard Giacomelli ◽

...

Keyword(s):

Case Report ◽

Facial Pain ◽

Cranial Nerves ◽

Sensory Nerve ◽

Intracranial Tumors ◽

Nerve Roots ◽

Primary Neoplasms ◽

Ophthalmic Branch ◽

The Brain ◽

Central Lesions

AbstractSchwannomas are the fourth most common primary neoplasms affecting the brain and cranial nerves. Central lesions commonly arise from sensory nerve roots, and a common intracranial site is the vestibular branch of the 8th nerve (>85%). We present the case report of a patient who has a schwannoma extending from the pterygopalatine fossa to the orbit, complaining about facial pain in the trajectory of the trigeminal ophthalmic branch. Schwannomas represent 1 to 2% of all neoplasms of the orbit, and trigeminal schwannomas are extremely rare, accounting for less than 0.5% of all intracranial tumors.

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Choroid plexus papilloma in an adult ewe – a case report

Acta Veterinaria Brno ◽

10.2754/avb201382010009 ◽

2013 ◽

Vol 82 (1) ◽

pp. 9-11

Author(s):

Jose María González ◽

Delia Lacasta ◽

Santiago Sanz ◽

María Climent ◽

Alicia Uixera ◽

...

Keyword(s):

Choroid Plexus ◽

Small Ruminant ◽

Choroid Plexus Papilloma ◽

Postural Reactions ◽

The Central Nervous System ◽

Primary Neoplasms ◽

The Right ◽

Veterinary Faculty ◽

The Brain ◽

Plexus Papilloma

Primary neoplasms of the central nervous system have been rarely reported in sheep. A three-year-old Rasa Aragonesa ewe was admitted to the small ruminant external consultancy at the Veterinary Faculty of University of Zaragoza, Spain. Clinical, haematological and neurological examinations were performed. Neurological examination showed signs of ataxia, hyperextension of the right front limb and abnormal postural reactions. The animal was unable to stand and walk, even with help. Patellar and flexor reflexes were normal and superficial sensation was present but decreased. Humanitarian sacrifice was carried out one month later. Gross and histopathological findings revealed a choroid plexus papilloma located in the fourth ventricle of the brain. To the authors’ knowledge this is the first description of this neoplastic disorder in sheep.

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Multiregional Sequencing of IDH-WT Glioblastoma Reveals High Genetic Heterogeneity and a Dynamic Evolutionary History

Cancers ◽

10.3390/cancers13092044 ◽

2021 ◽

Vol 13 (9) ◽

pp. 2044

Author(s):

Sara Franceschi ◽

Prospero Civita ◽

Francesco Pasqualetti ◽

Francesca Lessi ◽

Martina Modena ◽

...

Keyword(s):

Tumor Heterogeneity ◽

Evolutionary Dynamics ◽

Poor Overall Survival ◽

The Past ◽

Whole Exome ◽

Spatially Distributed ◽

Number Variation ◽

Primary Neoplasms ◽

One Year ◽

The Brain

Glioblastoma is one of the most common and lethal primary neoplasms of the brain. Patient survival has not improved significantly over the past three decades and the patient median survival is just over one year. Tumor heterogeneity is thought to be a major determinant of therapeutic failure and a major reason for poor overall survival. This work aims to comprehensively define intra- and inter-tumor heterogeneity by mapping the genomic and mutational landscape of multiple areas of three primary IDH wild-type (IDH-WT) glioblastomas. Using whole exome sequencing, we explored how copy number variation, chromosomal and single loci amplifications/deletions, and mutational burden are spatially distributed across nine different tumor regions. The results show that all tumors exhibit a different signature despite the same diagnosis. Above all, a high inter-tumor heterogeneity emerges. The evolutionary dynamics of all identified mutations within each region underline the questionable value of a single biopsy and thus the therapeutic approach for the patient. Multiregional collection and subsequent sequencing are essential to try to address the clinical challenge of precision medicine. Especially in glioblastoma, this approach could provide powerful support to pathologists and oncologists in evaluating the diagnosis and defining the best treatment option.

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Clinical, anatomopathological, and immunohistochemical findings of a transitional cell carcinoma from nasal cavity, frontal and ethmoidal sinus with meningoencephalic invasion in a dog

Open Veterinary Journal ◽

10.4314/ovj.v11i1.1 ◽

2021 ◽

Vol 11 (1) ◽

pp. 1-5

Author(s):

Leonardo L. Gorza ◽

Ayisa R. Oliveira ◽

Maryleydy G. Porto ◽

Vania C. Santos ◽

Isabela Hardt ◽

...

Keyword(s):

Oral Cavity ◽

Nasal Cavity ◽

Present Report ◽

Correct Diagnosis ◽

Transitional Cell ◽

Brain Invasion ◽

Appropriate Treatment ◽

Primary Neoplasms ◽

Neurological Alterations ◽

The Brain

Background: Primary neoplasms of the nasal cavity and sinuses are uncommon in domestic animals, most of which are of epithelial origin, being adenocarcinoma the most common tumor diagnosed in this region. Some malignant nasal cavity neoplasms may invade the brain causing clinical neurological signs, as well as purulent nasal secretion and epistaxis. Case Description: A case of neoplasm is reported in a 14-year-old pincher presenting dyspnea, epistaxis, and neurological alterations. Necropsy revealed the presence of a mass in the oral cavity vestibule, and another in the whole nasal cavity with invasion of the cribiform plate, meninges and brain. Squamous cells carcinoma was diagnosed in the oral cavity and transitional carcinoma in the nasal cavity. The immunohistochemistry confirmed that the brain infiltration was of the same origin as the nasal cavity neoplasm. Conclusion: The present report describes a rare case of transitional carcinoma of the nasal cavity as well as the frontal and ethmoidal sinuses with brain invasion, confirmed by immunohistochemistry. It is extremely important for veterinarians to include neoplasms in their differential diagnoses, when these animals show chronic respiratory signs and neurological alterations that do not improve with appropriate treatment, always associating with complementary exams, for correct diagnosis establishment and prognosis formulation.

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