scholarly journals Hepatocellular Carcinoma: Intra-arterial Delivery of Doxorubicin-loaded Hollow Gold Nanospheres for Photothermal Ablation—Chemoembolization Therapy in Rats

Radiology ◽  
2016 ◽  
Vol 281 (2) ◽  
pp. 427-435 ◽  
Author(s):  
Junjie Li ◽  
Min Zhou ◽  
Fengyong Liu ◽  
Chiyi Xiong ◽  
Wanqin Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gold Nanospheres ◽  
Hollow Gold Nanospheres ◽  
Photothermal Ablation

scholarly journals Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Rahul A. Sheth ◽  
Xiaoxia Wen ◽  
Junjie Li ◽  
Marites P. Melancon ◽  
Xin Ji ◽  
...  
Keyword(s):  
Gold Nanospheres ◽  
Hollow Gold Nanospheres ◽  
Photothermal Ablation

scholarly journals Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Nina M. Muñoz ◽  
Crystal Dupuis ◽  
Malea Williams ◽  
Katherine Dixon ◽  
Amanda McWatters ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Tumor Immunity ◽  
Rat Model ◽  
Thermal Ablation ◽  
Immune Modulation ◽  
Photothermal Ablation ◽  
Profiling Techniques ◽  
Tumor Immunogenicity ◽  
Tumor Specificity

AbstractThermal ablation is a standard therapy for patients with hepatocellular carcinoma (HCC). Contemporary ablation devices are imperfect, as they lack tumor specificity. An ideal ablation modality would generate thermal energy only within tumoral tissue. Furthermore, as hyperthermia is known to influence tumor immunity, such a tumor-specific ablation modality may have the ability to favorably modulate the tumor immune landscape. Here we show a clinically relevant thermal ablation modality that generates tumor-specific hyperthermia, termed molecularly targeted photothermal ablation (MTPA), that is based upon the excellent localization of indocyanine green to HCC. In a syngeneic rat model, we demonstrate the tumor-specific hyperthermia generated by MTPA. We also show through spatial and transcriptomic profiling techniques that MTPA favorably modulates the intratumoral myeloid population towards tumor immunogenicity and diminishes the systemic release of oncogenic cytokines relative to conventional ablation modalities.

Multifunctional magnetic-hollow gold nanospheres for bimodal cancer cell imaging and photothermal therapy

2015 ◽  
Vol 26 (31) ◽  
pp. 315701 ◽  
Author(s):  
Ling-Yu Bai ◽  
Xiao-Quan Yang ◽  
Jie An ◽  
Lin Zhang ◽  
Kai Zhao ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Photothermal Therapy ◽  
Cell Imaging ◽  
Gold Nanospheres ◽  
Cancer Cell Imaging ◽  
Hollow Gold Nanospheres
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