Effect of magnetic susceptibility contrast medium on myocardial signal intensity with fast gradient-recalled echo and spin-echo MR imaging: initial experience in humans.

Background Emerging quantitative cardiac magnetic resonance imaging (CMRI) techniques use cine balanced steady-state free precession (bSSFP) to measure myocardial signal intensity and probe underlying physiological parameters. This correlation assumes that steady-state is maintained uniformly throughout the heart in space and time. Purpose To determine the effects of longitudinal cardiac motion and initial slice position on signal deviation in cine bSSFP imaging by comparing two-dimensional (2D) and three-dimensional (3D) acquisitions. Material and Methods Nine healthy volunteers completed cardiac MRI on a 1.5-T scanner. Short axis images were taken at six slice locations using both 2D and 3D cine bSSFP. 3D acquisitions spanned two slices above and below selected slice locations. Changes in myocardial signal intensity were measured across the cardiac cycle and compared to longitudinal shortening. Results For 2D cine bSSFP, 46% ± 9% of all frames and 84% ± 13% of end-diastolic frames remained within 10% of initial signal intensity. For 3D cine bSSFP the proportions increased to 87% ± 8% and 97% ± 5%. There was no correlation between longitudinal shortening and peak changes in myocardial signal. The initial slice position significantly impacted peak changes in signal intensity for 2D sequences ( P < 0.001). Conclusion The initial longitudinal slice location significantly impacts the magnitude of deviation from steady-state in 2D cine bSSFP that is only restored at the center of a 3D excitation volume. During diastole, a transient steady-state is established similar to that achieved with 3D cine bSSFP regardless of slice location.

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Cyclic variation of myocardial signal intensity in real-time myocardial perfusion imaging

Journal of the American Society of Echocardiography ◽

10.1067/mje.2002.128471 ◽

2002 ◽

Vol 15 (12) ◽

pp. 1425-1431 ◽

Cited By ~ 5

Author(s):

Raffi Bekeredjian ◽

Alexander Hansen ◽

Arthur Filusch ◽

Alain-Eric Dubart ◽

Kleber Gaspar Carvallho da Silva ◽

...

Keyword(s):

Myocardial Perfusion Imaging ◽

Myocardial Perfusion ◽

Real Time ◽

Perfusion Imaging ◽

Signal Intensity ◽

Cyclic Variation ◽

Myocardial Signal ◽

Myocardial Signal Intensity

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Comparison of Single-Shot Fast Spin-Echo and Conventional Spin-Echo Sequences for MR Imaging of the Heart: Initial Experience

Radiology ◽

10.1148/radiology.219.2.r01ma27545 ◽

2001 ◽

Vol 219 (2) ◽

pp. 545-550 ◽

Cited By ~ 32

Author(s):

Olivier B. Vignaux ◽

Joelle Augui ◽

Joel Coste ◽

Christophe Argaud ◽

Patrick Le Roux ◽

...

Keyword(s):

Mr Imaging ◽

Spin Echo ◽

Fast Spin Echo ◽

Single Shot ◽

Initial Experience ◽

Conventional Spin Echo ◽

Fast Spin ◽

Spin Echo Sequences

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MR Imaging of Bone Metastases and Choice of Sequence: Spin Echo, In-Phase Gradient Echo, Diffusion, and Contrast Medium

Seminars in Musculoskeletal Radiology ◽

10.1055/s-0029-1220880 ◽

2009 ◽

Vol 13 (02) ◽

pp. 097-103 ◽

Cited By ~ 12

Author(s):

Daniel Vanel ◽

Roberto Casadei ◽

Marco Alberghini ◽

Manel Razgallah ◽

Maurizio Busacca ◽

...

Keyword(s):

Mr Imaging ◽

Bone Metastases ◽

Contrast Medium ◽

Spin Echo ◽

Gradient Echo ◽

Phase Gradient

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Quantitative Contrast-Enhanced MR Imaging of the Optic Nerve

Acta Radiologica ◽

10.1177/028418519403500604 ◽

1994 ◽

Vol 35 (6) ◽

pp. 526-531 ◽

Cited By ~ 1

Author(s):

J. H. Simon ◽

D. Rubinstein ◽

M. Brown ◽

W. Yuh ◽

M. Birch-Iensen ◽

...

Keyword(s):

Optic Nerve ◽

Mr Imaging ◽

Optic Neuritis ◽

Signal Intensity ◽

Pulse Sequence ◽

Spin Echo ◽

Fat Suppression ◽

Significant Enhancement ◽

Contrast Enhanced ◽

Frequency Selective

During the acute stages of optic neuritis damage to the blood-optic nerve barrier can be detected using i.v. paramagnetic contrast-enhanced MR imaging. Quantification of the enhancement pattern of the optic nerve, intraorbital fat and muscle was determined in 15 normal subjects using 3 fat-suppression MR imaging methods: T1-weighted spin-echo and spoiled gradient-echo sequences preceded by a fat-frequency selective pulse (FATSAT + SE and FATSAT + SPGR, respectively) and a pulse sequence combining CHOPPER fat suppression with a fat-frequency selective preparation pulse (HYBRID). Pre- and postcontrast-enhanced studies were acquired for FATSAT + SE and FATSAT + SPGR. There was no significant enhancement of the optic nerve by either method (mean increase of 0.96% and 5.3%, respectively), while there was significant enhancement in muscle (mean 118.2% and 108.2%), respectively; p < 0.005) and fat (mean increase of 13% and 37%, respectively; p < 0.05). Postcontrast optic nerve/muscle signal intensity ratios (mean, SD) were 0.51 (0.07), 0.58 (0.05) and 0.75 (0.05) for FATSAT + SE, FATSAT + SPGR and HYBRID, respectively. These results suggest a practical methodology and range of values for normal signal intensity increases and ratios of tissue signal that can be used as objective measures of optic neuritis for natural history studies and treatment trials.

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