scholarly journals Sonographic Assessment of Fetal Growth Abnormalities

Radiographics ◽  
2021 ◽  
Vol 41 (1) ◽  
pp. 268-288
Author(s):  
Michelle P. Debbink ◽  
Shannon L. Son ◽  
Paula J. Woodward ◽  
Anne M. Kennedy
RadioGraphics ◽  
2020 ◽  
Author(s):  
Michelle P. Debbink ◽  
Shannon L. Son ◽  
Paula J. Woodward ◽  
Anne M. Kennedy

RadioGraphics ◽  
2021 ◽  
Author(s):  
Michelle P. Debbink ◽  
Shannon L. Son ◽  
Paula J. Woodward ◽  
Anne M. Kennedy

2012 ◽  
Vol 46 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Thang M Nguyen ◽  
Hitomi Nakamura ◽  
Atsuko Wakabayashi ◽  
Takeshi Kanagawa ◽  
Shinsuke Koyama ◽  
...  

Ultrasonographic assessment of fetal growth to estimate fetal weight has been widely used in clinical obstetrics but not in laboratory mice. Even though it is important to assess fetal growth abnormalities for gene-targeting studies using mice, there have been no reports of accurately estimated fetal weight using fetal biometric parameters in mice. The aim of this study was to establish an accurate mouse formula using fetal biometric parameters under ultrasound imaging. Using a high-frequency ultrasound system with a 40 MHz transducer, we measured 293 fetuses of biparietal diameter and mean abdominal diameter from day 12.5 postcoitus (p.c.) until day 18.5 p.c every day. Thirteen algorithms for humans based on head and/or abdominal measurements were assessed. We established an accurate formula based on measurement of the abdomen in Jcl:ICR mice to investigate gestational complications, such as intrauterine growth restriction.


2011 ◽  
Vol 29 (02) ◽  
pp. 147-152 ◽  
Author(s):  
Benjamin Kase ◽  
Clint Cormier ◽  
Maged Costantine ◽  
Maria Hutchinson ◽  
Susan Ramin ◽  
...  

2005 ◽  
Vol 288 (3) ◽  
pp. R656-R662 ◽  
Author(s):  
Anette Ericsson ◽  
Bengt Hamark ◽  
Nina Jansson ◽  
Bengt R. Johansson ◽  
Theresa L. Powell ◽  
...  

Alterations in placental nutrient transfer have been implicated in fetal growth abnormalities. In pregnancies complicated by diabetes and accelerated fetal growth, upregulations of glucose transporter 1 (GLUT1) and amino acid transporter system A have been shown in the syncytiotrophoblast of term placenta. In contrast, intrauterine growth restriction is associated with a downregulation of placental system A transporters. However, underlying mechanisms of transporter regulation are poorly understood, particularly in early pregnancy. In this study, hormonal regulation of placental glucose and system A transporters was investigated. The uptake of 3-O-[methyl-14C]-d-glucose was studied in villous fragments isolated from first trimester (6–13 wk of gestation) and term human placenta. Villous fragments were incubated in buffer containing insulin, leptin, cortisol, growth hormone (GH), prolactin, IGF-I, or under hypo/hyperglycemic conditions for 1 h. Subsequently, 3-O-[methyl-14C]-d-glucose uptake was measured with and without phloretin for 70 s in first trimester tissue and 20 s in term tissue. Methylaminoisobutyric uptake was measured with and without Na+ for 20 min. Glucose uptake was unaltered by hormones or hypo/hyperglycemia. GH decreased system A activity by 31% in first trimester ( P < 0.05). The uptake of glucose was 50% higher in term compared with first trimester fragments and increased markedly between 6 and 13 wk of gestation ( P < 0.05). We conclude that placental glucose transporter activity is not regulated by short exposures to the hormones or glucose concentrations tested. In contrast to term placental villous fragments, system A activity was not regulated by insulin or leptin in first trimester but was downregulated by GH.


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