Biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3
1983 ◽
Vol 244
(2)
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pp. E159-E163
Keyword(s):
The biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3 was compared with 1,25-dihydroxyvitamin D3 in the rat. The 24,24-difluoro-1,25-dihydroxyvitamin D3 has a potency of approximately 5-10 times that of 1,25-dihydroxyvitamin D3 in the known in vivo vitamin D responsive systems. These systems include intestinal calcium transport, bone calcium mobilization, calcification of epiphyseal plate cartilage, and elevation of plasma calcium and phosphorus concentrations. Thus, 24,24-difluoro-1,25-dihydroxyvitamin D3 is the first known analogue with higher potency than 1,25-dihydroxyvitamin D3 in vivo.
1988 ◽
Vol 254
(4)
◽
pp. E402-E406
1989 ◽
Vol 273
(1)
◽
pp. 64-71
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Keyword(s):
1977 ◽
Vol 233
(3)
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pp. E160
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Keyword(s):
1983 ◽
Vol 258
(8)
◽
pp. 4977-4981
1978 ◽
Vol 253
(2)
◽
pp. 484-488
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1986 ◽
Vol 261
(34)
◽
pp. 16106-16114
2020 ◽
Vol 21
(2)
◽
pp. 470
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Keyword(s):