scholarly journals Mechanisms of increased vascular stiffness down the aortic tree in aging, premenopausal female monkeys

2020 ◽  
Vol 319 (1) ◽  
pp. H222-H234
Author(s):  
Denis Babici ◽  
Raymond K. Kudej ◽  
Tara McNulty ◽  
Jie Zhang ◽  
Marko Oydanich ◽  
...  
Keyword(s):  
Thoracic Aorta ◽  
Abdominal Aorta ◽  
Iliac Artery ◽  
Vascular Stiffness ◽  
Prior Work ◽  
Premenopausal Female

This is the first study to examine vascular stiffness down the aortic tree in aging premenopausal females (24 ± 0.7 yr old), whereas prior work studied mainly rodents, which are short-lived and do not undergo menopause. Histological mechanisms mediating vascular stiffness in older premenopausal females increased progressively down the aortic tree, with greater increases in the abdominal aorta compared with the thoracic aorta and with the greatest increases and differences observed in the iliac artery.

scholarly journals IgG4-related aortitis/periaortitis and periarteritis: a distinct spectrum of IgG4-related disease

2020 ◽  
Author(s):  
Linyi Peng ◽  
Panpan Zhang ◽  
Jieqiong Li ◽  
Zheng Liu ◽  
Hui Lu ◽  
...  
Keyword(s):  
Thoracic Aorta ◽  
Abdominal Aorta ◽  
Iliac Artery ◽  
Treatment Efficacy ◽  
Male Predominance ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Serum Igg4 ◽  
Type 3

Abstract Background: Large vessels could be involved in IgG4-related disease(IgG4-RD).This study aimed to clarify the clinical features and evaluate the treatment efficacy for IgG4-RD with aortitis/periaortitis and periarteritis (PAO/PA). Methods: This study enrolled 587 IgG4-RD patients in a prospective cohort with a follow-up time for more than 6 months. The distribution of IgG4-related PAO/PA was classified into four types: type 1, thoracic aorta; type 2a, abdominal aorta; type 2b, abdominal aorta and iliac artery; type 2c, iliac artery; type 3, thoracic and abdominal aorta; type 4, other arteries. Patient’s demographic data, clinical characteristics, laboratory parameters, and treatment efficacy were analyzed. Results: Of 587 IgG4-RD patients, 89(15.2%) had PAO/PA. The average age was 58.3±11.1 years, with male predominance (85.4%). Vessels affected were as follows: abdominal aorta (83.1%), iliac artery (70.8%), thoracic aorta (13.5%) and other vessels (13.5%). The most prevalent distribution type of IgG4-related PAO/PA was type 2b, with 74 (83.1%) patients, followed by type 2a, type 2c, type 3, and type 1. 55 (61.8%) PAO/PA patients had hydronephrosis, with renal insufficiency occurred in 43 (48.3%), and 31 (34.8%) PAO/PA patients had D-J stent drainage due to severe ureteral obstruction. After treatment with glucocorticoid and immunosuppressants, 82% patients achieved a remission with shrinking of perivascular mass. Conclusions: IgG4-RD with PAO/PA was distinct from non-PAO/PA in demographic features, organs involvement distribution, inflammatory markers, serum IgG4 and IgE. The most common affected vessel was abdominal aorta, and most patients responded well with treatment.

scholarly journals IgG4-related aortitis/periaortitis and periarteritis: a distinct spectrum of IgG4-related disease

2020 ◽  
Author(s):  
Linyi Peng ◽  
Panpan Zhang ◽  
Jieqiong Li ◽  
Zheng Liu ◽  
Hui Lu ◽  
...  
Keyword(s):  
Thoracic Aorta ◽  
Abdominal Aorta ◽  
Iliac Artery ◽  
Treatment Efficacy ◽  
Demographic Data ◽  
Male Predominance ◽  
Related Disease ◽  
Serum Igg4 ◽  
Type 3

Abstract Background: Large vessels could be involved in immunoglobulin (Ig)-G4-related disease (IgG4-RD). This study aimed to clarify the clinical features and evaluate the treatment efficacy for IgG4-RD with aortitis/periaortitis and periarteritis (PAO/PA).Methods: This study prospectively enrolled 587 patients with IgG4-RD with a follow-up time of more than 6 months. The distribution of IgG4-related PAO/PA was classified into four types: type 1, thoracic aorta; type 2a, abdominal aorta; type 2b, abdominal aorta and iliac artery; type 2c, iliac artery; type 3, thoracic and abdominal aorta; type 4, other arteries. Patient’s demographic data, clinical characteristics, laboratory parameters, and treatment efficacy were analyzed.Results: Of 587 IgG4-RD patients, 89 (15.2%) had PAO/PA. The average age was 58.3±11.1 years, with male predominance (85.4%). Vessels affected were as follows: abdominal aorta (83.1%), iliac artery (70.8%), thoracic aorta (13.5%), and other vessels (13.5%). The most prevalent distribution type of IgG4-related PAO/PA was type 2b, with 74 (83.1%) patients, followed by type 2a, type 2c, type 3, and type 1. Fifty-five (61.8%) PAO/PA patients had hydronephrosis, with renal insufficiency occurring in 43 (48.3%), and 31 (34.8%) PAO/PA patients had D-J stent drainage due to severe ureteral obstruction. After treatment with a glucocorticoid and immunosuppressants, 82% patients achieved remission with shrinking of the perivascular mass by more than 30%.Conclusions: IgG4-RD with PAO/PA was distinct from non-PAO/PA in demographic features, organ involvement distribution, inflammatory markers, and serum IgG4 and IgE. The most common affected vessel was the abdominal aorta, and most patients responded well with treatment.

scholarly journals Morphologic and epidemiologic differences between Asian and European population in aneurismatic disease of abdominal aorta

2015 ◽  
Vol 62 (2) ◽  
pp. 25-32
Author(s):  
Ana Mladenovic
Keyword(s):  
Risk Factors ◽  
Abdominal Aorta ◽  
Iliac Artery ◽  
Protective Factor ◽  
Common Iliac Artery ◽  
European Population ◽  
Transverse Diameter ◽  
Aorta Aneurysm ◽  
Control Subjects ◽  
Asian Patients

Background: In this study, we analyzed epidemiologic characteristics and morphologic differences between Asian and European population in patients with abdominal aorta aneurysm (AAA). Method: We conducted concomitant study in Japan and Europe , in 31 Asian patients (AP) with AAA and 130 control subjects of the same population, and in 30 European patients with AAA and 126 control subjects (EP). We observed various demographic and anthropologic parameters. Aortography was performed in all patients at the same type of CT-scanners using the same examination protocol and postprocessing. For data analysis, various statistical models were used. Results: There are statistically significant differences in multiple epidemiologic and morphologic findings in AAA patients, as well as in comparison with controls in both groups. This is most distinct in terms of anthropologic characteristics and number of risk-factors, and in terms of morphologic findings, in the length of neck of the aneurysm, transverse diameter of abdominal aorta (AA) and common iliac artery (c.i.a), and volumes of c.i.a. We obtained paradoxical results considering diabetes mellitus, which presented itself as a protective factor for AAA. Conclusion: Demographic-epidemiologic analysis accompanied with morphologic measurements using modern imaging modalities enables obtaining new information on pathology of AAA in different races. There are differences in number of risk-factors, and in terms of morphologic findings, in the length neck, angle of the aneurysm, transverse diameters of abdominal aorta (AA) and in the length of common iliac artery (c.i.a), and volume of c.i.a.

Control of Hemorrhage in Critical Femoral or Inguinal Penetrating Wounds—An Ultrasound Evaluation

2006 ◽  
Vol 21 (6) ◽  
pp. 379-382 ◽  
Author(s):  
Michael Blaivas ◽  
Stephen Shiver ◽  
Matthew Lyon ◽  
Srikar Adhikari
Keyword(s):  
Flow Velocity ◽  
Abdominal Aorta ◽  
Femoral Artery ◽  
Iliac Artery ◽  
Common Femoral Artery ◽  
Body Armor ◽  
Mean Flow ◽  
Mean Velocity ◽  
Flow Measurements ◽  
Ultrasound Evaluation

AbstractIntroduction:Exsanguination from a femoral artery wound can occur in sec-onds and may be encountered more often due to increased use of body armor. Some military physicians teach compression of the distal abdominal aorta (Abdominal Aorta) with a knee or a fist as a temporizing measure.Objective:The objective of this study was to evaluate if complete collapse of the Abdominal Aorta was feasible and with what weight it occurs.Methods:This was a prospective, interventional study at a Level-I, academ-ic, urban, emergency department with an annual census of 80,000 patients. Written, informed consent was obtained from nine male volunteers after Institutional Research Board approval. Any patient who presented with abdominal pain or had undergone previous abdominal surgery was excluded from the study. Subjects were placed supine on the floor to simulate an injured soldier. Various dumbbells of increasing weight were placed over the distal Abdominal Aorta, and pulsed-wave Doppler measurements were taken at the right common femoral artery (CFA). Dumbbells were placed on top of a tightly bundled towel roughly the surface area of an adult knee. Flow measurements at the CFA were taken at increments of 20 pounds. This was repeated with weight over the proximal right artery iliac and distal right iliac artery to eval- uate alternate sites. Descriptive statistics were utilized to evaluate the data.Results:The mean velocity through the CFA was 75.8 cm/ sec at 0 pounds. Compression of the Abdominal Aorta ranging 80 to 140 pounds resulted in no flow in the CFA. A steady decrease in mean flow velocity was seen starting with 20 pounds. Flow velocity decreased more rapidly with compression of the prox- imal right iliac artery, and stopped in all nine volunteers by 120 pounds of pressure. For all nine volunteers, up to 80 pounds of pressure over the distal iliac artery failed to decrease CFA flow velocity, and no subject was able to tolerate more weight at that location.Conclusion:Flow to the CFA can be stopped completely with pressure over the distal Abdominal Aorta or proximal iliac artery in catastrophic wounds. Compression over the proximal iliac artery worked best, but a first responder still may need to apply upward of 120 pounds of pressure to stop exsanguination.

scholarly journals Late Outcome after Surgery for Type-A Aortic Dissection

2020 ◽  
Vol 9 (9) ◽  
pp. 2731
Author(s):  
Mikko Jormalainen ◽  
Peter Raivio ◽  
Fausto Biancari ◽  
Caius Mustonen ◽  
Hannu-Pekka Honkanen ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Thoracic Aorta ◽  
Abdominal Aorta ◽  
Cumulative Incidence ◽  
Type I ◽  
Descending Thoracic Aorta ◽  
Late Outcome ◽  
Type A Aortic Dissection ◽  
Primary Surgery ◽  
All Cause Mortality

The aim of this study was to evaluate all-cause mortality and aortic reoperations after surgery for Stanford type A aortic dissection (TAAD). We evaluated the late outcome of patients who underwent surgery for acute TAAD from January 2005 to December 2017 at the Helsinki University Hospital, Finland. We studied 309 patients (DeBakey type I TAAD: 89.3%) who underwent repair of TAAD. Aortic root repair was performed in 94 patients (30.4%), hemiarch repair in 264 patients (85.4%) and partial/total aortic arch repair in 32 patients (10.4%). Hospital mortality was 13.6%. At 10 years, all-cause mortality was 34.9%, and the cumulative incidence of aortic reoperation or late aortic-related death was 15.6%, of any aortic reoperation 14.6%, reoperation on the aortic root 6.6%, on the aortic arch, descending thoracic and/or abdominal aorta 8.7%, on the descending thoracic and/or abdominal aorta 6.4%, and on the abdominal aorta 3.8%. At 10 years, cumulative incidence of reoperation on the distal aorta was higher in patients with a diameter of the descending thoracic aorta ≥35 mm at primary surgery (cumulative incidence in the overall series: 13.2% vs. 4.0%, SHR 3.993, 95%CI 1.316–12.120; DeBakey type I aortic dissection: 13.6% vs. 4.5%, SHR 3.610, 95%CI 1.193–10.913; patients with dissected descending thoracic aorta: 15.8% vs. 5.9%, SHR 3.211, 95%CI 1.067–9.664). In conclusion, surgical repair of TAAD limited to the aortic segments involved by the intimal tear was associated with favorable survival and a low rate of aortic reoperations. However, patients with enlarged descending thoracic aorta at primary surgery had higher risk of late reoperation. Half of the distal aortic reinterventions were performed on the abdominal aorta.

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