Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography

2008 ◽  
Vol 295 (4) ◽  
pp. H1705-H1711 ◽  
Author(s):  
Bas M. van Dalen ◽  
Osama I. I. Soliman ◽  
Wim B. Vletter ◽  
Folkert J. ten Cate ◽  
Marcel L. Geleijnse
Keyword(s):  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Age Groups ◽  
The Elderly ◽  
Left Ventricular ◽  
Basal Rot ◽  
Age Related ◽  
Rotational Deformation ◽  
The Difference ◽  
Age Related Changes

The increasing number and proportion of aged individuals in the population warrants knowledge of normal physiological changes of left ventricular (LV) biomechanics with advancing age. LV twist describes the instantaneous circumferential motion of the apex with respect to the base of the heart and has an important role in LV ejection and filling. This study sought to investigate the biomechanics behind age-related changes in LV twist by determining a broad spectrum of LV rotation parameters in different age groups, using speckle tracking echocardiography (STE). The final study population consisted of 61 healthy volunteers (16–35 yr, n = 25; 36–55 yr, n = 23; 56–75 yr, n = 13; 31 men). LV peak systolic rotation during the isovolumic contraction phase (Rotearly), LV peak systolic rotation during ejection (Rotmax), instantaneous LV peak systolic twist (Twistmax), the time to Rotearly, Rotmax, and Twistmax, and rotational deformation delay (defined as the difference of time to basal Rotmax and apical Rotmax) were determined by STE using QLAB Advanced Quantification Software (version 6.0; Philips, Best, The Netherlands). With increasing age, apical Rotmax ( P < 0.05), time to apical Rotmax ( P < 0.01), and Twistmax ( P < 0.01) increased, whereas basal Rotearly ( P < 0.001), time to basal Rotearly ( P < 0.01), and rotational deformation delay ( P < 0.05) decreased. Rotational deformation delay was significantly correlated to Twistmax ( R2 = 0.20, P < 0.05). In conclusion, Twistmax increased with aging, resulting from both increased apical Rotmax and decreased rotational deformation delay between the apex and the base of the LV. This may explain the preservation of LV ejection fraction in the elderly.

Abstract 15891: Age-Related Changes of Right Atrial and Right Ventricular Functions Assessed by Speckle Tracking Echocardiography

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Roxana Cristina G Rimbas ◽  
Simona Ionela Calin ◽  
Oana Aurelia Enescu ◽  
Sorina Mihaila ◽  
Dragos Vinereanu
Keyword(s):  
Strain Rate ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Systolic Function ◽  
Right Atrial ◽  
Reservoir Function ◽  
Age Related ◽  
Global Strain ◽  
Rv Function ◽  
Age Related Changes

Introduction: Limited data are reported about age-related changes of the RA phasic functions, assessed by speckle tracking echocardiography (STE), and their correlation with the RV function. Methods: 131 normal subjects (19-78 yrs, 89 women), divided in 4 age groups, were studied by conventional, tissue Doppler, and STE. Active RA function was assessed from negative global strain at atrial contraction (GSA-) and derived time from P onset (TGSA-), and late diastolic SR (GSRL); passive function from positive global strain at TVO (GSA+) and time from R to peak (TGSA+), and from early negative diastolic global strain rate (GSRE); reservoir function from the sum of GSA- and GSA+ (SUMGSA), positive global SR at the beginning of RV systole (GSR+) and derived time from P onset (TGSR+). RA volumes were measured. RV systolic function was assessed from TAPSE, FAC, S’, global systolic strain (GS) and strain rate (RVSRs); diastolic function from early and late global SR (RVSRe and RVSRl). Results: Active RA function was not affected by age, but RA contraction time was longer over 50 yrs. Reservoir function decreased starting from 50 yrs (GRS+), but especially over 60 yrs (SUMGSA, TGRS+). Passive function also decreased over 50 yrs (GSA+, TGSA+, GSRE). RV systolic function was not affected by age, whereas RVSRe decreased, and RVSRl increased over 50 yrs (Table). Global RV function (TAPSE, FAC) did not correlate with any of the RA functions. However, longitudinal RV systolic function (RVSRs, GS, S’) correlated inversely with active function (GSA-, GSRL). RVSRe had positive correlation with RA reservoir (SUMGSA, GSR+), and also with passive function (GSA+, GSRE) (r=0.4, p<0.001). Atrial volumes were not affected by age. Conclusion: Active RA function is not affected by age. Passive and reservoir RA functions, and diastolic RV function decreased over 50 yrs. Longitudinal systolic RV correlates with active RA function, and diastolic RV function with passive and reservoir RA functions.

Abstract 16343: Normal Values and Age Related Changes of Left and Right Atrial Phasic Functions by Speckle Tracking Echocardiography

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Roxana Cristina G Rimbas ◽  
Simona Ionela Calin ◽  
Oana Aurelia Enescu ◽  
Sorina Mihaila ◽  
Dragos Vinereanu
Keyword(s):  
Speckle Tracking ◽  
Age Groups ◽  
Normal Subjects ◽  
Right Atrial ◽  
Active Function ◽  
Reservoir Function ◽  
Age Related ◽  
Atrial Contraction ◽  
Contraction And Relaxation ◽  
Age Related Changes

Introduction: Limited data are reported about age related changes of LA and RA functions, and interatrial relationship. Methods: 131 normal subjects (19-78 yrs, 89 women), divided in 4 age groups, were studied by conventional and speckle tracking echo (STE). LA and RA volumes were measured: pre atrial contraction (Vp), minimal (Vmin), and maximal (Vmax), and computed to define atrial ejection fractions: active EF = (Vp-Vmin)/Vp; expansion index EI = (Vmax-Vmin)/Vmin; passive EF = (Vmax-Vp)/Vmax. Active function was assessed from negative strain at atrial contraction (GSA-) and time from P onset to peak (TGSA-), and late diastolic strain rate (GSRL); passive function from positive global strain (GSA+) and time from R to peak (TGSA+), and from early negative diastolic SR (GSRE); reservoir function from the sum of GSA- and GSA+ (SUMGSA), positive global SR at the beginning of ventricular systole (GSR+) and derived time from P onset (TGSR+). We defined for LA a maximal difference (DIF) of all derived times, as a measurement of LA synchrony, and also a difference between RA times and maximal correspondent LA times, as an interatrial synchrony. Results: All LAEFs, Vmin, and Vp decreased over 50 yrs, and Vmax over 60 yrs. RA reservoir function decreased over 60 yrs, while passive RA function over 50 yrs. Active LA function (GSRL) decreased over 60 yrs. LA reservoir and conduit function decreased over 50 yrs. All derived times were increased over 40 yrs. LA and also interatrial contraction and relaxation synchrony were altered only after 60 yrs (all p<0.001) (Tables). Correspondent RA and LA functions are significantly correlated, irrespective of age (r=0.6, p<0.001). Conclusion: Although LA and RA functions are strongly correlated, they have different age related changes. RA volumes, EFs, and active function were not affected by age, whereas LAEFs, volumes, passive and reservoir LA and RA functions decreased over 50 yrs. LA and also interatrial synchrony were altered after 60 yrs.

Age-related Changes in Left Ventricular Twist Assessed by Two-dimensional Speckle-tracking Imaging

2006 ◽  
Vol 19 (9) ◽  
pp. 1077-1084 ◽  
Author(s):  
Masaaki Takeuchi ◽  
Hiromi Nakai ◽  
Michiko Kokumai ◽  
Tomoko Nishikage ◽  
Shinichiro Otani ◽  
...  
Keyword(s):  
Speckle Tracking ◽  
Left Ventricular ◽  
Two Dimensional ◽  
Speckle Tracking Imaging ◽  
Age Related ◽  
Left Ventricular Twist ◽  
Ventricular Twist ◽  
Age Related Changes

scholarly journals Analysis of left ventricular rotational deformation by 2D speckle tracking echocardiography: a feasibility study in athletes

2021 ◽  
Author(s):  
Phillipp Hofrichter ◽  
Andreas Hagendorff ◽  
Ulrich Laufs ◽  
Sven Fikenzer ◽  
Pierre Hepp ◽  
...  
Keyword(s):  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Image Acquisition ◽  
Left Ventricular ◽  
Control Group ◽  
Radial Deformation ◽  
Short Axis ◽  
Physiological Strain ◽  
2D Speckle Tracking ◽  
Rotational Deformation

Abstract2D speckle tracking echocardiography (2DSTE) is established to analyse left ventricular (LV) longitudinal function. The analysis of LV rotational deformation is challenging and requires standardization of image acquisition as well as postprocessing analysis. The aim of this study was to test the feasibility to analyse LV rotational deformation using 2DSTE by introducing a novel algorithm for the detection of artefacts. The study was performed in 20 healthy subjects serving as a control group and in 53 competitive sportsmen. Circumferential, radial strain (CS, RS) and LV rotation were analysed by 2DSTE in parasternal short axis views. The stepwise algorithm to exclude potential artefacts starts with the visual estimation of the image quality with respect to complete visualization of all myocardial segments during the entire cardiac cycle followed by the exclusion of data sets in participants with conduction abnormalities. The next step is the optimization of tracking areas and a cross-check of implausible strain waveforms in multiple acquired comparable cineloops. The last step is the exclusion of strain curves with persisting implausible waveforms if standardization failures and incorrect LV wall tracking are fixed. Plausible physiological strain curves were observed in 89% (n = 65/73) of all subjects. In controls all implausible waveforms could be verified as artefacts. The algorithm was applied in 53 professional athletes to test and confirm its feasibility. Abnormal CS waveforms were documented in 25 athletes, verified as artefacts due to tracking failures in 22 athletes and due to incorrect image acquisition in 3 athletes. CS artefacts were mostly located in the basal posterior and lateral LV segments. (endocardial: 6%, n = 4/70; p < 0.05) and basal posterior (endocardial: 8%, n = 5/70; p < 0.05) segments were highly susceptible to artefacts. 2DSTE of parasternal short axis views to analyse circumferential and radial deformation as well as LV rotation is feasible in athletes. The proposed algorithm helps to avoid artefacts and might contribute to standardization of this technique. 2DSTE might provide an interesting diagnostic tool for the detection of viral myocarditis, e.g. in athletes.

AGE-RELATED CHANGES OF THE PROFILE FIELD OF NEURONS OF THE AREA 7 OF THE BRAIN OF MEN AND WOMEN IN THE PROCESS OF THE AGING

2019 ◽  
Vol 27 (3) ◽  
pp. 8-15
Author(s):  
P. A. Agapov ◽  
I. N. Bogolepova ◽  
L. I. Malofeeva
Keyword(s):  
Pyramidal Neurons ◽  
Age Groups ◽  
The Elderly ◽  
Men And Women ◽  
Age Related ◽  
Female Brain ◽  
Group 5 ◽  
The Brain ◽  
Age Related Changes ◽  
Profile Field

The aim of the work is to study changes in the profile field of pyramidal neurons in the cortex of field 7 of the brain of men and women in the aging process. A cytoarchitectonic study of the cortex of field 7 of the upper parietal region of the brain of men and women was carried out on a series of frontal paraffin sections stained by the Nissl method. The brain preparations of men and women of three age groups were studied: the groups of mature age (from 20 to 60 years), the elderly group (from 60 to 75 years) and the group of senile age (from 75 years and older). In each age group, 5 preparations of the male brain and 5 preparations of the female brain were studied. Age-related changes in the cytoarchitectonics of the profile field of pyramidal neurons in the cytoarchitectonic layers of the third and fifth cortex fields 7 of the brain of men and women were studied. As a result of the study, it was revealed that in the process of aging of the brain of men and women, changes in similar morphometric indicators of field 7 cortex occur at different age periods, the dynamics of age-related changes in functionally different cytoarchitectonic layers III and V of the cerebral cortex of men and women are also different.

Age-Related Changes in Left Ventricular Torsion as Assessed by 2-Dimensional Ultrasound Speckle Tracking Imaging

2008 ◽  
Vol 38 (10) ◽  
pp. 529 ◽  
Author(s):  
Hyun Jik Lee ◽  
Bong Soo Kim ◽  
Jae Hoon Kim ◽  
Hee Sang Jang ◽  
Byung Seok Bae ◽  
...  
Keyword(s):  
Speckle Tracking ◽  
Left Ventricular ◽  
Speckle Tracking Imaging ◽  
Left Ventricular Torsion ◽  
Age Related ◽  
Ventricular Torsion ◽  
Age Related Changes

Automatic Change Detection in Older and Younger Women: A Visual Mismatch Negativity Study

Gerontology ◽  
2018 ◽  
Vol 64 (4) ◽  
pp. 318-325 ◽  
Author(s):  
István Sulykos ◽  
Zsófia Anna Gaál ◽  
István  Czigler
Keyword(s):  
Visual Processing ◽  
Mismatch Negativity ◽  
Stimulus Change ◽  
Age Groups ◽  
The Elderly ◽  
Event Related Potential ◽  
Visual Mismatch Negativity ◽  
Age Related ◽  
Latency Range ◽  
Age Related Changes

Background: In comparison to controlled (attentional) processing, relatively little is known about the age-related changes of the earlier (preattentive) processes. An event-related potential (ERP) index of preattentive (automatic) visual processing, the visual mismatch negativity (vMMN) is a good candidate for analyzing age-related differences in the automatic processing of visual events. Objective: So far results concerning age-related changes in vMMN have been equivocal. Our aim was to develop a method resulting in a reliable vMMN in a paradigm short enough to use in the applied field. Methods: We investigated an older (mean age: 66.4 years, n = 15) and a younger (mean age: 22.4 years, n = 15) group of healthy women. ERPs were obtained for checkerboard onset patterns in a passive oddball condition (during which participants performed a tracking task). One of the checkerboards was frequent (standard; p = 0.8), and the other was rare (deviant; p = 0.2). Results: vMMN emerged over posterior locations in the latency range of 100–300 ms in both age groups. The amplitude of the earlier part of the vMMN was similar in the older and the younger participants, but latency was longer in the older group. The later part of the vMMN was slightly diminished in the elderly. Conclusion: Automatic detection of violated sequential regularities, reflected by the vMMN, emerged in the two age groups (earlier vMMN). However, detection of stimulus change, a preattentive visual process delayed in the elderly, and identification of the specific change was compromised in the older participants.

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