Abstract 16343: Normal Values and Age Related Changes of Left and Right Atrial Phasic Functions by Speckle Tracking Echocardiography

Introduction: Limited data are reported about age related changes of LA and RA functions, and interatrial relationship. Methods: 131 normal subjects (19-78 yrs, 89 women), divided in 4 age groups, were studied by conventional and speckle tracking echo (STE). LA and RA volumes were measured: pre atrial contraction (Vp), minimal (Vmin), and maximal (Vmax), and computed to define atrial ejection fractions: active EF = (Vp-Vmin)/Vp; expansion index EI = (Vmax-Vmin)/Vmin; passive EF = (Vmax-Vp)/Vmax. Active function was assessed from negative strain at atrial contraction (GSA-) and time from P onset to peak (TGSA-), and late diastolic strain rate (GSRL); passive function from positive global strain (GSA+) and time from R to peak (TGSA+), and from early negative diastolic SR (GSRE); reservoir function from the sum of GSA- and GSA+ (SUMGSA), positive global SR at the beginning of ventricular systole (GSR+) and derived time from P onset (TGSR+). We defined for LA a maximal difference (DIF) of all derived times, as a measurement of LA synchrony, and also a difference between RA times and maximal correspondent LA times, as an interatrial synchrony. Results: All LAEFs, Vmin, and Vp decreased over 50 yrs, and Vmax over 60 yrs. RA reservoir function decreased over 60 yrs, while passive RA function over 50 yrs. Active LA function (GSRL) decreased over 60 yrs. LA reservoir and conduit function decreased over 50 yrs. All derived times were increased over 40 yrs. LA and also interatrial contraction and relaxation synchrony were altered only after 60 yrs (all p<0.001) (Tables). Correspondent RA and LA functions are significantly correlated, irrespective of age (r=0.6, p<0.001). Conclusion: Although LA and RA functions are strongly correlated, they have different age related changes. RA volumes, EFs, and active function were not affected by age, whereas LAEFs, volumes, passive and reservoir LA and RA functions decreased over 50 yrs. LA and also interatrial synchrony were altered after 60 yrs.

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Abstract 15891: Age-Related Changes of Right Atrial and Right Ventricular Functions Assessed by Speckle Tracking Echocardiography

Circulation ◽

10.1161/circ.130.suppl_2.15891 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Roxana Cristina G Rimbas ◽

Simona Ionela Calin ◽

Oana Aurelia Enescu ◽

Sorina Mihaila ◽

Dragos Vinereanu

Keyword(s):

Strain Rate ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Systolic Function ◽

Right Atrial ◽

Reservoir Function ◽

Age Related ◽

Global Strain ◽

Rv Function ◽

Age Related Changes

Introduction: Limited data are reported about age-related changes of the RA phasic functions, assessed by speckle tracking echocardiography (STE), and their correlation with the RV function. Methods: 131 normal subjects (19-78 yrs, 89 women), divided in 4 age groups, were studied by conventional, tissue Doppler, and STE. Active RA function was assessed from negative global strain at atrial contraction (GSA-) and derived time from P onset (TGSA-), and late diastolic SR (GSRL); passive function from positive global strain at TVO (GSA+) and time from R to peak (TGSA+), and from early negative diastolic global strain rate (GSRE); reservoir function from the sum of GSA- and GSA+ (SUMGSA), positive global SR at the beginning of RV systole (GSR+) and derived time from P onset (TGSR+). RA volumes were measured. RV systolic function was assessed from TAPSE, FAC, S’, global systolic strain (GS) and strain rate (RVSRs); diastolic function from early and late global SR (RVSRe and RVSRl). Results: Active RA function was not affected by age, but RA contraction time was longer over 50 yrs. Reservoir function decreased starting from 50 yrs (GRS+), but especially over 60 yrs (SUMGSA, TGRS+). Passive function also decreased over 50 yrs (GSA+, TGSA+, GSRE). RV systolic function was not affected by age, whereas RVSRe decreased, and RVSRl increased over 50 yrs (Table). Global RV function (TAPSE, FAC) did not correlate with any of the RA functions. However, longitudinal RV systolic function (RVSRs, GS, S’) correlated inversely with active function (GSA-, GSRL). RVSRe had positive correlation with RA reservoir (SUMGSA, GSR+), and also with passive function (GSA+, GSRE) (r=0.4, p<0.001). Atrial volumes were not affected by age. Conclusion: Active RA function is not affected by age. Passive and reservoir RA functions, and diastolic RV function decreased over 50 yrs. Longitudinal systolic RV correlates with active RA function, and diastolic RV function with passive and reservoir RA functions.

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Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00513.2008 ◽

2008 ◽

Vol 295 (4) ◽

pp. H1705-H1711 ◽

Cited By ~ 73

Author(s):

Bas M. van Dalen ◽

Osama I. I. Soliman ◽

Wim B. Vletter ◽

Folkert J. ten Cate ◽

Marcel L. Geleijnse

Keyword(s):

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Age Groups ◽

The Elderly ◽

Left Ventricular ◽

Basal Rot ◽

Age Related ◽

Rotational Deformation ◽

The Difference ◽

Age Related Changes

The increasing number and proportion of aged individuals in the population warrants knowledge of normal physiological changes of left ventricular (LV) biomechanics with advancing age. LV twist describes the instantaneous circumferential motion of the apex with respect to the base of the heart and has an important role in LV ejection and filling. This study sought to investigate the biomechanics behind age-related changes in LV twist by determining a broad spectrum of LV rotation parameters in different age groups, using speckle tracking echocardiography (STE). The final study population consisted of 61 healthy volunteers (16–35 yr, n = 25; 36–55 yr, n = 23; 56–75 yr, n = 13; 31 men). LV peak systolic rotation during the isovolumic contraction phase (Rotearly), LV peak systolic rotation during ejection (Rotmax), instantaneous LV peak systolic twist (Twistmax), the time to Rotearly, Rotmax, and Twistmax, and rotational deformation delay (defined as the difference of time to basal Rotmax and apical Rotmax) were determined by STE using QLAB Advanced Quantification Software (version 6.0; Philips, Best, The Netherlands). With increasing age, apical Rotmax ( P < 0.05), time to apical Rotmax ( P < 0.01), and Twistmax ( P < 0.01) increased, whereas basal Rotearly ( P < 0.001), time to basal Rotearly ( P < 0.01), and rotational deformation delay ( P < 0.05) decreased. Rotational deformation delay was significantly correlated to Twistmax ( R2 = 0.20, P < 0.05). In conclusion, Twistmax increased with aging, resulting from both increased apical Rotmax and decreased rotational deformation delay between the apex and the base of the LV. This may explain the preservation of LV ejection fraction in the elderly.

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P946 Right atrial volumetric and functional analysis by three-dimensional speckle-tracking echocardiography in acromegaly

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.579 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

A Kormanyos ◽

A Kalapos ◽

P Domsik ◽

N Gyenes ◽

N Ambrus ◽

...

Keyword(s):

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Three Dimensional ◽

Radial Strain ◽

Human Growth ◽

Active Phase ◽

Right Atrial ◽

Control Group ◽

Cardiovascular Comorbidities ◽

Atrial Contraction

Abstract Introduction Acromegaly is a chronic, rare hormonal disease associated with major cardiovascular comorbidities. The disease, in the majority of the cases, is caused by a benign human growth hormone secreting adenoma. Cardiovascular involvement is especially common in acromegaly patients from the most common hypertension to cardiomyopathy. It was set out to quantify right atrial (RA) morphology and function in a group of acromegaly patients using three-dimensional (3D) speckle-tracking echocardiography (3DSTE). Methods The study comprised 30 patients from which 8 patients were excluded due to inadequate image quality. Mean age of the remaining acromegaly patients were 53.7 ± 14.5 years (7 males). Ten patients were in active phase, while 12 subjects had inactive acromegaly. In the control group 40 healthy adults were enrolled (mean age: 52.3 ± 8.2 years, 15 males). In each case, complete two-dimensional Doppler echocardiography was performed followed by 3DSTE. Results Maximum (54.5 ± 14.4 ml vs. 47.2 ± 11.6 ml, p <0.05) and minimum (35.5 ± 10.2 ml vs. 29.2 ± 9.1 ml, p <0.05) RA volumes and RA volume before atrial contraction (45.1 ± 11.1 ml vs. 38.2 ± 10.3 ml, p <0.05) were significantly higher in case of acromegaly compared to the healthy controls. Both global and mean segmental peak 3D strain (-11.94 ± 7.52% vs. -8.07 ± 5.03%, p <0.05 and -17.16 ± 6.13% vs. -13.78 ± 5.35%, p <0.05) were higher in the acromegaly group compared to the controls. At atrial contraction, mean segmental radial strain (-13.22 ± 6.45% vs. -9.74 ± 4.58%, p <0.05) was significantly higher and mean segmental 3D strain (-9.78 ± 5.44% vs. -13.78 ± 5.35%, p <0.05) was significantly lower in the acromegaly group compared to the controls. Between the active and inactive group of acromegaly patients, mean segmental longitudinal strain (28.17 ± 4.89% vs. 35.34 ± 9.75%, p <0.05) was significantly different. Numerous independent strain parameters had significant correlations with different hormonal variables in the active acromegaly group. These correlations were not present in the inactive acromegaly subgroup. Conclusion Acromegaly is associated with significant RA volumetric and functional abnormalities.

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Determination of age-related changes in human soluble interleukin 2 receptor in body fluids of normal subjects as a control value against disease states

Clinica Chimica Acta ◽

10.1016/s0009-8981(99)00161-8 ◽

1999 ◽

Vol 289 (1-2) ◽

pp. 89-97 ◽

Cited By ~ 11

Author(s):

Yoshimitsu Gotoh ◽

Yoshihiro Okamoto ◽

Osamu Uemura ◽

Naoko Mori ◽

Soichi Tanaka ◽

...

Keyword(s):

Interleukin 2 ◽

Normal Subjects ◽

Body Fluids ◽

Control Value ◽

Interleukin 2 Receptor ◽

Disease States ◽

Age Related ◽

Soluble Interleukin 2 Receptor ◽

Age Related Changes

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Age-related changes in sleep in depressed and normal subjects

Psychiatry Research ◽

10.1016/0165-1781(81)90010-x ◽

1981 ◽

Vol 4 (1) ◽

pp. 73-78 ◽

Cited By ~ 165

Author(s):

J.Christian Gillin ◽

Wallace C. Duncan ◽

Dennis L. Murphy ◽

Robert M. Post ◽

Thomas A. Wehr ◽

...

Keyword(s):

Normal Subjects ◽

Age Related ◽

Age Related Changes

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Age-related changes in behavioural and emotional problems in Smith–Magenis syndrome measured with the Developmental Behavior Checklist

Journal of Intellectual Disabilities ◽

10.1177/1744629519901056 ◽

2020 ◽

pp. 174462951990105 ◽

Cited By ~ 1

Author(s):

Heidi Elisabeth Nag ◽

Terje Nærland

Keyword(s):

Age Groups ◽

Emotional Problems ◽

Chromosome 17 ◽

Adaptive Behaviour ◽

Genetic Syndrome ◽

Developmental Behavior ◽

Age Related ◽

Autism Symptomatology ◽

Behavioural And Emotional Problems ◽

Age Related Changes

Smith–Magenis syndrome (SMS) is a genetic syndrome most often caused by a deletion on chromosome 17 or more rarely by a mutation in the retinoic acid-induced 1 gene. The aim of this study was to investigate the Developmental Behavior Checklist (DBC) profile of persons with SMS and the associations between behavioural and emotional problems, age, gender, adaptive behaviour and autism symptomatology. Twenty-eight persons with SMS were represented by their parents in this study. DBC Total scores are reduced with age, but they still show a mean that is clearly above the cut-off of 46. The differences between the age groups <9 years and 9–17 years ( p = 0.024) and between the age groups <9 years and >18 years ( p = 0.007) are significant. We found a significant decrease in behavioural and emotional problems with age in SMS. We did not find a relationship between adapted behaviour and communication and behavioural and emotional problems.

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Age-related changes in the pharyngeal structure and function in sleep apnea and normal subjects

Principles and Practice of Geriatric Sleep Medicine ◽

10.1017/cbo9780511770661.010 ◽

2010 ◽

pp. 75-84

Author(s):

Giora Pillar ◽

David P. White ◽

Atul Malhotra

Keyword(s):

Sleep Apnea ◽

Normal Subjects ◽

Structure And Function ◽

Age Related ◽

And Function ◽

Age Related Changes

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Investigation of Age-Related Changes in the Skin Microbiota of Korean Women

Microorganisms ◽

10.3390/microorganisms8101581 ◽

2020 ◽

Vol 8 (10) ◽

pp. 1581

Author(s):

Minseok Kim ◽

Tansol Park ◽

Jung Im Yun ◽

Hye Won Lim ◽

Na Rae Han ◽

...

Keyword(s):

Age Groups ◽

Alpha Diversity ◽

Amplicon Sequencing ◽

Diversity Indices ◽

Rrna Gene ◽

Korean Women ◽

Skin Microbiota ◽

Microbial Distribution ◽

Age Related ◽

Age Related Changes

The microbiota of human skin is influenced by host and environmental factors. To determine if chronological age influences the composition of the skin microbiota on the forehead and hands, 73 Korean women were sorted into one of three age groups: (1) 10–29 years (n = 24), (2) 30–49 years (n = 21), and (3) 50–79 years (n = 28). From the 73 women, 146 skin samples (two skin sites per person) were collected. 16S rRNA gene amplicon sequencing was then conducted to analyze the skin microbiota. The overall microbial distribution varied on the forehead but was similar on the hands across the three age groups. In addition, the composition of the skin microbiota differed between the forehead and hands. Commensal microbiota, such as Streptococcus, Staphylococcus, Cutibacterium, and Corynebacterium, which contribute to maintaining skin health via dominant occupation, were affected by increasing age on forehead and hand skin. Alpha diversity indices increased significantly with age on forehead skin. This study indicates that older people may be more susceptible to pathogenic invasions due to an imbalanced skin microbiota resulting from age-related changes. The results of our study may help develop new strategies to rebalance skin microbiota shifted during aging.

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