Effect of aerobic and resistance exercise training on vascular function in heart failure

2000 ◽  
Vol 279 (4) ◽  
pp. H1999-H2005 ◽  
Author(s):  
Andrew Maiorana ◽  
Gerard O'Driscoll ◽  
Lawrence Dembo ◽  
Craig Cheetham ◽  
Carmel Goodman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Vascular Function ◽  
Exercise Program ◽  
Resistance Exercise Training ◽  
Forearm Exercise ◽  
Dose Levels ◽  
Exercise Stimulus ◽  
Hyperemic Flow ◽  
Forearm Vascular Resistance

Exercise training of a muscle group improves local vascular function in subjects with chronic heart failure (CHF). We studied forearm resistance vessel function in 12 patients with CHF in response to an 8-wk exercise program, which specifically excluded forearm exercise, using a crossover design. Forearm blood flow (FBF) was measured using strain-gauge plethysmography. Responses to three dose levels of intra-arterial acetylcholine were significantly augmented after exercise training when analyzed in terms of absolute flows (7.0 ± 1.8 to 10.9 ± 2.1 ml · 100 ml−1 · min−1 for the highest dose, P < 0.05 by ANOVA), forearm vascular resistance (21.5 ± 5.0 to 15.3 ± 3.9 ml · 100 ml forearm−1 · min−1, P< 0.01), or FBF ratios ( P < 0.01, ANOVA). FBF ratio responses to sodium nitroprusside were also significantly increased after training ( P < 0.05, ANOVA). Reactive hyperemic flow significantly increased in both upper limbs after training (27.9 ± 2.7 to 33.5 ± 3.1 ml · 100 ml−1 · min−1, infused limb; P < 0.05 by paired t-test). Exercise training improves endothelium-dependent and -independent vascular function and peak vasodilator capacity in patients with CHF. These effects on the vasculature are generalized, as they were evident in a vascular bed not directly involved in the exercise stimulus.

scholarly journals The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes

2001 ◽  
Vol 38 (3) ◽  
pp. 860-866 ◽  
Author(s):  
Andrew Maiorana ◽  
Gerard O’Driscoll ◽  
Craig Cheetham ◽  
Lawrence Dembo ◽  
Kim Stanton ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Vascular Function ◽  
Resistance Exercise Training

scholarly journals The effect of an acute exercise bout on plasme miRNA and its relation with cardiovascular adaptation to exercise training in heart failure

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
I Witvrouwen ◽  
E Boeren ◽  
N Possemiers ◽  
W Hens ◽  
P.J Beckers ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Ejection Fraction ◽  
Aerobic Capacity ◽  
Vascular Function ◽  
Acute Exercise ◽  
Exercise Bout ◽  
Funding Source ◽  
Percent Change ◽  
Adaptation To Exercise

Abstract Background Exercise training (ET) improves aerobic capacity (VO2peak) in heart failure with reduced ejection fraction (HFrEF), but the individual response is highly variable. Underlying mechanisms of this variability are still not fully elucidated yet. Specific miRNA might be involved in cardiovascular adaptation to exercise, as changes in miRNA levels with repetitive acute exercise bouts have been described. miR-23a, -140, -146a, -191 and -210 have been related to aerobic capacity, endothelial function and angiogenesis. Purpose First, to evaluate if vascular function-associated miRNAs are related to vascular function and aerobic capacity in HFrEF patients. Second, to evaluate the effect of a single exercise bout on the miR profile. Third, to evaluate if miRNA changes in response to acute exercise are related to aerobic and vascular response to training. Methods Plasma levels of miR-23a, -140, -146a, -191 and -210 were analyzed using RT-qPCR in 24 HFrEF patients, before and immediately after a cardiopulmonary exercise test (CPET) and repeated after 15 weeks of ET. At baseline and after 15 weeks, VO2peak, flow-mediated dilation (FMD), pulsed wave velocity (PWV) and heart rate-corrected augmentation index (Aix@75) were recorded. Results In this prospective study, 24 HFrEF patients were included. Mean age was 56.9±12.9 years, mean left ventricular ejection fraction 31.7±7.0% and median adherence to ET was 41 sessions (30–43). Mean percent change in VO2peak was 2.86% (±13.5), in Aix@75 −9.8% (±80.9), in FMD 79.1% (±223.7) and in PWV −3.1% (±11.2), however these changes were not significant compared to baseline (p&gt;0.05). At baseline, none of the miRNA were correlated with percent change in VO2peak (all p&gt;0.05), however, miR-140 showed a trend towards correlation (r=−0.385, p=0.063). miR-191was significantly correlated with Aix@75 at baseline and after 15 weeks (respectively r=0.588, p=0.013 and r=0.609, p=0.006) and miR-23a was significantly correlated with FMD at baseline and showed a trend at 15 weeks (respectively r=0.462, p=0.040 and r=0.417, p=0.076). An acute exercise bout resulted in a significant decrease of miR-191 (1.82 before and 1.58 after CPET; 14% decrease, p=0.043). This change was significantly correlated with percent change in Aix@75 (r=−0.730, p=0.005) after ET. In a linear regression model adjusted for age, change in miR-191 significantly predicted percent change in Aix@75 (B=−84.5, p=0.043). Conclusion In HFrEF patients, plasma levels of miR-191 significantly decrease in response to an acute exercise bout. Baseline levels of vascular function-associated miRNAs were correlated with arterial stiffness and endothelial function before and after exercise training, which may suggest that these miRNAs are implicated in the vascular adaptations due to repetitive acute exercise bouts. However, these findings need to be validated in larger cohorts. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Fund for scientific research-Flanders (FWO)

Resistance exercise training increases muscle strength, endurance, and blood flow in patients with chronic heart failure

1999 ◽  
Vol 83 (12) ◽  
pp. 1674-1677 ◽  
Author(s):  
David L Hare ◽  
Toni M Ryan ◽  
Steve E Selig ◽  
Anne-Marie Pellizzer ◽  
Tim V Wrigley ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Chronic Heart Failure ◽  
Muscle Strength ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Resistance Exercise Training

Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise

2012 ◽  
Vol 112 (3) ◽  
pp. 347-353 ◽  
Author(s):  
Bethan Phillips ◽  
John Williams ◽  
Philip Atherton ◽  
Kenneth Smith ◽  
Wulf Hildebrandt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Vascular Function ◽  
Whole Body ◽  
Middle Aged ◽  
Resistance Exercise Training ◽  
Vascular Conductance ◽  
Leg Blood Flow ◽  
Age Related

One manifestation of age-related declines in vascular function is reduced peripheral (limb) blood flow and vascular conduction at rest and in response to vasodilatory stimuli such as exercise and feeding. Since, even in older age, resistance exercise training (RET) represents an efficacious strategy for increasing muscle mass and function, we hypothesized that likewise RET would improve age-related declines in leg blood flow (LBF) and vascular conductance (LVC). We studied three mixed-sex age groups (young: 18–28 yr, n = 14; middle aged: 45–55 yr, n = 20; older: 65–75 yr, n = 17) before and after 20 wk of whole body RET in the postabsorptive state (BASAL) and after unilateral leg extensions (6 × 8 repetitions; 75% 1 repetition maximum) followed by intermittent mixed-nutrient liquid feeds (∼6.5 kJ·kg−1·30 min−1), which allowed us to discern the acute effects of feeding (nonexercised leg; FED) and exercise plus feeding (exercised leg; FEDEX) on vascular function. We measured LBF using Doppler ultrasound and recorded mean arterial pressure (MAP) to calculate LVC. Our results reveal that although neither age nor RET influenced BASAL LBF, age-related declines in LBF responses to FED were eradicated by RET. Moreover, increases in LBF after FEDEX, which occurred only in young and middle-aged groups before RET (+73 ± 9%, and +90 ± 13%, P < 0.001, respectively), increased in all groups after RET (young +78 ± 10%, middle-aged +96 ± 15%, older +80 ± 19%, P < 0.001). Finally, RET robustly improved LVC under FASTED, FED, and FEDEX conditions in the older group. These data provide novel information that supports the premise that RET represents a valuable strategy to counter age-related impairments in LBF/LVC.

Sign in / Sign up

Export Citation Format

Share Document