T1332 Electroacupuncture Improves Impaired Gastric Accommodation and Vagal Activity in a Novel Rodent Model of Functional Dyspepsia

2008 ◽  
Vol 134 (4) ◽  
pp. A-533 ◽  
Author(s):  
Geng-Qing Song ◽  
Yan Sun ◽  
Liansheng Liu ◽  
Pankaj J. Pasricha ◽  
Jiande Chen
Keyword(s):  
Functional Dyspepsia ◽  
Rodent Model ◽  
Vagal Activity ◽  
Gastric Accommodation

Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity

2021 ◽  
Author(s):  
Ying Zhu ◽  
Feng xu ◽  
Dewen Lu ◽  
Peijing Rong ◽  
Jiafei Cheng ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Slow Waves ◽  
Dyspeptic Symptom ◽  
Vagal Activity ◽  
Gastric Accommodation ◽  
Efferent Activity ◽  
Gastric Slow Waves

Objectives: This study was designed to investigate whether transcutaneous auricular vagal nerve stimulation (taVNS) would be able to improve major pathophysiologies of functional dyspepsia (FD) in patients with FD. Methods: Acute: Thirty-six FD patients (21F) were studied in two sessions (taVNS and sham-ES). Physiological measurements, including gastric slow waves, gastric accommodation and autonomic functions, were assessed by the electrogastrogram (EGG), a nutrient drink test and the spectral analysis of heart rate variability derived from the electrocardiogram (ECG), respectively. Chronic: Thirty-six FD patients (25F) were randomized to receive 2-week taVNS or sham-ES. The dyspeptic symptom scales, anxiety and depression scores and the same physiological measurements were assessed at the beginning and the end of the 2-week treatment. Results: Acute: In comparison with sham-ES, acute taVNS improved gastric accommodation (p=0.008), increased the percentage of normal gastric slow waves (%NSW, fasting: p=0.010; fed: p=0.007) and vagal activity (fasting: p=0.056; fed: p=0.026). Chronic：In comparison with baseline, 2-week taVNS but not sham-ES reduced symptoms of dyspepsia (p=0.010), decreased the scores of anxiety (p=0.002) and depression (p<0.001), improved gastric accommodation (p<0.001) and the %NSW (fasting: p<0.05; fed: p<0.05) by enhancing vagal efferent activity (fasting: p=0.015; fed: p=0.048). Compared with the HC, the patients showed increased anxiety (p<0.001) and depression (p<0.001), and decreased gastric accommodation (p<0.001) and %NSW (p<0.001) as well as decreased vagal activity (fasting: p=0.047). Conclusions: The noninvasive taVNS has a therapeutic potential for treating non-severe FD by improving gastric accommodation and gastric pace-making activity via enhancing vagal activity.

scholarly journals Effects of electroacupuncture on stress-induced gastric dysrhythmia and mechanisms involving autonomic and central nervous systems in functional dyspepsia

2020 ◽  
Vol 319 (1) ◽  
pp. R106-R113
Author(s):  
Sujuan Zhang ◽  
Yi Liu ◽  
Shiying Li ◽  
Feng Ye ◽  
Robert D. Foreman ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Restraint Stress ◽  
Rodent Model ◽  
Plasma Norepinephrine ◽  
Vagal Activity ◽  
Plastic Tube ◽  
Gastric Dysrhythmia ◽  
Gastric Slow Wave ◽  
Cell Counts ◽  
Acute Restraint Stress

Electroacupuncture (EA) is widely used as an effective method to treat stress-related disorders. However, its mechanisms remain largely unknown. The aim of this study was to investigate the effects and mechanisms of EA on gastric slow wave (GSW) dysrhythmia and c-Fos expression in the nucleus of the solitary tract (NTS) induced by stress in a rodent model of functional dyspepsia (FD). Rats in the neonatal stage were treated using intragastric iodoacetamide. Eight weeks later, the rats were implanted with electrodes in the stomach for the measurement of GSW and electrodes into accupoints ST36 for EA. Autonomic functions were assessed by spectral analysis of heart rate variability. Rats were placed for 30 min in a cylindrical plastic tube for acute restraint stress. The involvement of a central afferent pathway was assessed by measuring c-Fos-immunoreactive cells in the NTS. 1) EA normalized restraint stress-induced impairment of GSW in FD rats. 2) EA significantly increased vagal activity ( P = 0.002) and improved sympathovagal balance ( P = 0.004) under stress in FD rats. 3) In FD rats under restraint stress, plasma norepinephrine concentration was increased substantially ( P < 0.01), which was suppressed with EA. 4) The EA group showed increased c-Fos-positive cell counts in the NTS compared with the sham EA group ( P < 0.05) in FD rats. Acute restraint stress induces gastric dysrhythmia in a rodent model of FD. EA at ST36 improves GSW under stress in FD rats mediated via the central and autonomic pathways, involving the NTS and vagal efferent pathway.

scholarly journals Ameliorating Effect of Transcutaneous Electroacupuncture on Impaired Gastric Accommodation in Patients with Postprandial Distress Syndrome-Predominant Functional Dyspepsia: A Pilot Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Feng Xu ◽  
Yan Tan ◽  
Zhihui Huang ◽  
Nina Zhang ◽  
Yuemei Xu ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Motility ◽  
Distress Syndrome ◽  
Therapeutic Potential ◽  
Vagal Activity ◽  
Gastric Accommodation ◽  
Fed State ◽  
Gastric Slow Waves ◽  
Drink Test ◽  
Tolerable Volume

Patients with functional dyspepsia (FD) have both reduced gastric accommodation and impaired gastric motility that are difficult to treat. The aim of this study was to investigate the therapeutic potential of transcutaneous electroacupuncture (TEA) for both of these disorders in FD patients. Acute experiments were performed in FD patients to study the effect of TEA and sham-TEA on gastric accommodation assessed by a nutrient drink test and gastric motility assessed by the measurement of the electrogastrogram (EGG). TEA or sham-TEA was performed via cutaneous electrodes at acupoints ST36 and PC6 or sham-points nonacupoints. It was found that (1) gastric accommodation (maximum tolerable volume) was reduced in FD patients compared with the controlsP<0.03. TEA improved gastric accommodation in FD patientsP<0.02. (2) Acute TEA significantly increased the percentage and power of normal gastric slow waves in the fed state assessed in the FD patients by the EGG in comparison with sham-TEA. (3) TEA increased vagal activity assessed by the spectral analysis of the heart rate variability in the fed state in FD patients. It was concluded that needleless method of transcutaneous electroacupuncture may have a therapeutic potential for treating both impaired gastric accommodation and impaired gastric motility in patients with FD.

Persian herbal medicine in functional dyspepsia: a systematic review article.

2020 ◽  
Vol 17 ◽  
Author(s):  
Maryam Azimi ◽  
Mohammad Javad Zahedi
Keyword(s):  
Clinical Trials ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Crocus Sativus ◽  
Herbal Remedies ◽  
Asparagus Racemosus ◽  
Gastric Accommodation ◽  
Cynara Scolymus

Introduction: According to Rome IV, functional dyspepsia is diagnosed with presence of dyspepsia in the absence of organic or metabolic causes. FD caused by several factors such as impaired gastric accommodation and hypersensitivity to gastric distention. Several studies have reported effectiveness of herbal medicine on FD. This article, thus, reviews Persian herbal medicine in FD. Method: Electronic databases including Pubmed, Scopus, Cochrain, Embase, Web of science and Ovid were searched so as to find clinical articles related to dyspepsia and herbal medicine by July 2019. Our search strategies were traditional medicine, complementary and alternative medicine, herb, plant, and dyspepsia. We excluded all articles except Persian clinical trials. Results: We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like Asparagus racemosus, Brassica oleracea, Cynara scolymus, Ocimum basilicum, Mentha longifolia, Mentha pulegium, Mentha piperata, Pimpinella anisum, Nigella sativa, Mastic gum, Curcuma longa, Pistatio atlantica, Glycyrrhiza glabra, Solanum tuberosum and Zingiber officinale and compound remedies of Rosa damascene & Crocus sativus, Trachyspermum copticom & Apium graveolence, Carum carvi & Mentha pipperata, Gingiber officinalis & Cynara scolymus are effective in functional dyspepsia. Conclusion: Many people use herbal and traditional remedies for treatment of disorders such as gastrointestinal disordersو , especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD.

scholarly journals Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying

2017 ◽  
Vol 46 (2) ◽  
pp. 792-801 ◽  
Author(s):  
W-J Guo ◽  
S-K Yao ◽  
Y-L Zhang ◽  
S-Y Du ◽  
H-F Wang ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Delayed Gastric Emptying ◽  
Low Frequency ◽  
Treatment Method ◽  
Frequency Component ◽  
High Frequency Component ◽  
Vagal Activity ◽  
Nervous Function

Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio. Results Overall and proximal GE were delayed in 47.2% and 50.9% of the patients, respectively. Spectral analysis of HRV showed that the HF in patients with delayed proximal GE was significantly lower and that the LF/HF ratio was significantly higher than those in patients with normal proximal GE after a meal. Conclusion Delayed proximal GE might be caused by disrupted sympathovagal balance as a result of decreased vagal activity after a meal. Improvement in vagal activity may constitute an effective treatment method for patients with FD.

Gastric Accommodation in Functional Dyspepsia

1997 ◽  
Vol 32 (3) ◽  
pp. 193-197 ◽  
Author(s):  
Arnold Berstad ◽  
Trygve Hauksen ◽  
Odd Helge Gilja ◽  
Kristian Hveem ◽  
Karl Anton Undeland ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Accommodation

scholarly journals Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial

2020 ◽  
Vol 318 (4) ◽  
pp. G635-G645 ◽  
Author(s):  
Justin Brandler ◽  
Laurence J. Miller ◽  
Xiao Jing Wang ◽  
Duane Burton ◽  
Irene Busciglio ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Animal Studies ◽  
Delayed Gastric Emptying ◽  
Gastrointestinal Hormones ◽  
Receptor Activation ◽  
Gastric Accommodation ◽  
Double Blind ◽  
Secretin Receptor ◽  
Therapeutic Mechanism

Abnormal gastric accommodation (GA) and gastric emptying contribute to pathophysiology in functional dyspepsia (FD). Secretin is a key regulator of GA in animal studies. Our aim was to study the effects of secretin on gastric motility, satiation, postprandial symptoms, and key hormones. We performed two double-blind, randomized, saline-controlled crossover trials in 10 healthy volunteers and 10 patients with FD by Rome IV criteria. We used measured GA (by validated SPECT method) after a 111In radiolabeled Ensure 300-mL meal and quantified gastric emptying for 30 min by scintigraphy. Satiation was measured by volume to fullness (VTF) and maximum tolerated volume (MTV) on an Ensure nutrient drink test and postprandial symptoms 30 min post-MTV. Fasting and postprandial GLP-1, GIP, and HPP were measured. The ages and sex distribution of healthy controls and patients with FD were similar. Compared with placebo, secretin delayed gastric emptying at 30 min in both health [−11% (−16, −4), P = 0.004]; and FD [−8% (−9, 0), P = 0.03]. Satiation (VTF and MTV), GA, and plasma levels of GLP-1, GIP, and HPP did not differ between treatment arms in health or FD. On ANCOVA analysis (adjusting for age and sex), secretin did not consistently increase postprandial symptoms in health or FD. Secretin delayed gastric emptying in both health and FD without significantly altering GA, VTF, or MTV or selected hormones. Thus, secretin receptor activation may provide a novel therapeutic mechanism for patients with FD and rapid gastric emptying. NEW & NOTEWORTHY The naturally occurring hormone secretin retards gastric emptying of solids without deleteriously affecting gastric accommodation, satiation, other upper gastrointestinal hormones, or postprandial symptoms. Given these findings, a subset of patients with rapid gastric emptying (e.g., the estimated 20% of patients with functional dyspepsia) could be candidates for treatments that stimulate a secretin receptor such as sacubitril, which inhibits neprilysin, an enzyme that degrades secretin.

Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats

2010 ◽  
Vol 298 (4) ◽  
pp. G563-G570 ◽  
Author(s):  
Jieyun Yin ◽  
Jie Chen ◽  
Jiande D. Z. Chen
Keyword(s):  
Therapeutic Potential ◽  
Diabetic Rats ◽  
Intestinal Transit ◽  
Vagal Activity ◽  
Gastric Accommodation ◽  
Small Intestinal Transit ◽  
Gastric Dysrhythmia ◽  
Gastric Slow Wave ◽  
Normal Percentage ◽  
Small Intestinal

The aim of this study was to investigate the effects and mechanisms of electroacupuncture (EA) on gastric accommodation, gastric dysrhythmia, and gastric emptying (GE) in streptozotocin (STZ)-induced diabetic rats. Five experiments were performed in five groups of STZ-induced diabetic rats to study the effects of EA at ST-36 (Zusanli) on gastric slow-wave dysrhythmia, delayed GE and intestinal transit, impaired gastric accommodation, and the mechanisms of EA involving the autonomic and opioidergic pathways. We found the following: 1) EA improved gastric dysrhythmia in the diabetic rats. The normal percentage of slow waves was 55.4 ± 2.9% at baseline and significantly increased to 69.2 ± 2.2% with EA ( P = 0.01); this effect was blocked by naloxone. 2) EA resulted in a 21.4% increase in GE and 18.2% increase in small intestinal transit in the diabetic rats. 3) EA restored diabetes-induced impairment in gastric accommodation. Gastric accommodation was 0.98 ± 0.13 ml with sham EA and significantly increased to 1.21 ± 0.15 ml with EA ( P = 0.01), and this effect was blocked by naloxone. 4) EA increased vagal activity assessed by the spectral analysis of the heart rate variability. We concluded that EA at ST-36 improves gastric dysrhythmia, delayed GE and intestinal transit, and impaired accommodation in STZ-induced diabetic rats, and the improvement seems to be mainly mediated via the vagal pathway. EA may have a promising therapeutic potential for diabetic gastroparesis.

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