A nomogram relating pO2, pH, temperature, and hemoglobin saturation in the dog.

1966 ◽  
Vol 21 (1) ◽  
pp. 195-201 ◽  
Author(s):  
R G Rossing ◽  
S M Cain
Keyword(s):  
Hemoglobin Saturation

scholarly journals Near-simultaneous hemoglobin saturation and oxygen tension maps in mouse brain using an AOTF microscope

1997 ◽  
Vol 73 (3) ◽  
pp. 1223-1231 ◽  
Author(s):  
R.D. Shonat ◽  
E.S. Wachman ◽  
W. Niu ◽  
A.P. Koretsky ◽  
D.L. Farkas
Keyword(s):  
Oxygen Tension ◽  
Mouse Brain ◽  
Hemoglobin Saturation

Low P50 in deer mice native to high altitude

1985 ◽  
Vol 58 (1) ◽  
pp. 193-199 ◽  
Author(s):  
L. R. Snyder
Keyword(s):  
High Altitude ◽  
Significant Negative Correlation ◽  
Deer Mice ◽  
Hypoxic Stress ◽  
Hemoglobin Saturation ◽  
Partial Pressures ◽  
Theoretical Predictions ◽  
Low Altitude ◽  
The Difference

Whereas it is widely believed that animals native to high altitude show lower O2 partial pressures at 50% hemoglobin saturation (P50) than do related animals native to low altitude, that “fact” has not been well documented. Consequently, P50 at pH 7.4, PCO2(7.4), the CO2 Bohr effect, and the buffer slope (delta log PCO2/delta pH) were determined via the mixing technique in Peromyscus maniculatus native to a range of altitudes but acclimated to 340 or 3,800 m. PCO2(7.4) and buffer slope were substantially lower at high altitude. The change in P50(7.4) between acclimation altitudes was minimal (0.8% increase at 3,800 m), because of counterbalancing changes in PCO2, 2,3-diphospho-D-glycerate concentration, and perhaps other factors. At both acclimation altitudes there was a highly significant negative correlation between P50(7.4) and native altitude. Since pH in vivo probably increases slightly at high altitude, the data on P50 corrected to pH 7.4 are probably underestimates of the difference in in vivo P50 at low vs. high altitude. Hence these results corroborate theoretical predictions that low P50 is advantageous under severe hypoxic stress.

Vasomotion induces regular major oscillations in jejunal mucosal tissue oxygenation

1994 ◽  
Vol 266 (6) ◽  
pp. G978-G986 ◽  
Author(s):  
W. Hasibeder ◽  
R. Germann ◽  
H. Sparr ◽  
M. Haisjackl ◽  
B. Friesenecker ◽  
...  
Keyword(s):  
Tissue Oxygenation ◽  
Jejunal Mucosa ◽  
Blood Gas ◽  
Acid Base ◽  
Oxygen Extraction Ratio ◽  
Physiological Basis ◽  
Midline Laparotomy ◽  
Jejunal Segment ◽  
Hemoglobin Saturation ◽  
The Mean

The mucosa of the small intestine has some unique microcirculatory features that may result in significant tissue oxygenation changes even under physiological conditions. To prove this hypothesis we investigated mucosal and serosal oxygenation in an autoperfused, innervated jejunal segment in pigs. Eight animals (30-40 kg) were anesthetized, paralyzed, and normoventilated. A small segment of the jejunal mucosa and serosa was exposed by a midline laparotomy and an antimesenteric incision. Mucosal and serosal oxygen tensions were measured using Clark-type surface oxygen electrodes. Mucosal hemoglobin saturation and concentration were determined by tissue reflectance spectrophotometry. Systemic hemodynamics, mesenteric-venous acid base, and blood gas variables, as well as systemic acid-base and blood gas variables and jejunal electromyogenic potentials, were recorded. Measurements were performed after a rest period at 0, 30, 60, and 90 min. All animals remained hemodynamically stable. At time 0 the jejunal oxygen extraction ratio was 0.33 +/- 0.05, the mean serosal PO2 was 60.25 +/- 7.69, the mean mucosal PO2 was 25.47 +/- 4.41 mmHg, and the mean mucosal hemoglobin saturation was 46.36 +/- 6.22%. Mean values did not change with time. In contrast to serosal PO2, mucosal PO2, mucosal hemoglobin oxygen saturation, and hemoglobin concentration showed rhythmic oscillations with a frequency of 3.4-5 cycles/min that were unrelated to systemic hemodynamic parameters, respiratory frequency, and intestinal peristalsis. From this we concluded that the jejunal mucosa demonstrates significant, regular changes in oxygenation parameters that are locally mediated. We speculate that the physiological basis for this phenomenon is the countercurrent arrangement of microvessels in conjunction with vasomotion.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sharon E. Cox ◽  
Julie Makani ◽  
Charles R. Newton ◽  
Andrew M. Prentice ◽  
Fenella J. Kirkham
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Clinical Chemistry ◽  
Pearson Correlation ◽  
Transferrin Saturation ◽  
Full Blood Count ◽  
Hemoglobin F ◽  
Hemoglobin Saturation ◽  
Highly Correlated ◽  
Glucose 6 Phosphate Dehydrogenase

Low hemoglobin oxygen saturation (SpO2) is common in Sickle Cell Anemia (SCA) and associated with complications including stroke, although determinants remain unknown. We investigated potential hematological, genetic, and nutritional predictors of daytime SpO2 in Tanzanian children with SCA and compared them with non-SCA controls. Steady-state resting pulse oximetry, full blood count, transferrin saturation, and clinical chemistry were measured. Median daytime SpO2 was 97% (IQ range 94–99%) in SCA (N = 458), lower () than non-SCA (median 99%, IQ range 98–100%; N = 394). Within SCA, associations with SpO2 were observed for hematological variables, transferrin saturation, body-mass-index z-score, hemoglobin F (HbF%), genotypes, and hemolytic markers; mean cell hemoglobin (MCH) explained most variability (, Adj ). In non-SCA only age correlated with SpO2. -thalassemia 3.7 deletion highly correlated with decreased MCH (Pearson correlation coefficient 0.60, ). In multivariable models, lower SpO2 correlated with higher MCH (-coefficient 0.32, ) or with decreased copies of -thalassemia 3.7 deletion (-coefficient 1.1, ), and independently in both models with lower HbF% (-coefficient 0.15, ) and Glucose-6-Phosphate Dehydrogenase genotype (-coefficient 1.12, ). This study provides evidence to support the hypothesis that effects on red cell rheology are important in determining SpO2 in children with SCA. Potential mechanisms and implications are discussed.

Venous blood flow measurement by determination of change in venous hemoglobin saturation

2000 ◽  
Vol 28 (9) ◽  
pp. 3181-3184 ◽  
Author(s):  
Yasuhiro Umemoto ◽  
Shinichi Nishi ◽  
Mituo Shindoh ◽  
Akira Asada
Keyword(s):  
Blood Flow ◽  
Flow Measurement ◽  
Venous Blood ◽  
Venous Blood Flow ◽  
Blood Flow Measurement ◽  
Hemoglobin Saturation

Velocity of O2 uptake by human red blood cells

1961 ◽  
Vol 16 (3) ◽  
pp. 511-516 ◽  
Author(s):  
N. C. Staub ◽  
J. M. Bishop ◽  
R. E. Forster
Keyword(s):  
Rate Constant ◽  
Intermediate Compound ◽  
Oxygen Electrode ◽  
Theoretical Explanation ◽  
Association Rate Constant ◽  
Association Rate ◽  
Human Red Blood Cells ◽  
Hemoglobin Saturation ◽  
Uptake Process ◽  
Normal Human

We have determined the over-all association rate constant, k'c, for the uptake of oxygen by normal human erythrocytes from 0% to 97% initial hemoglobin saturation at pH 7.4 and 37óC. With a modified Hartridge-Roughton rapid-reaction apparatus, we used a small oxygen electrode to follow the oxygen uptake process rather than using the usual photocolorimetric analytical methods. The value of k'c averages 164 mm-1 sec.-1 at 0% initial saturation, rises slowly to over 300 at 50%, and then climbs rapidly to over 1500 at 95%. The theoretical explanation for the increase in k-c with rising initial oxyhemoglobin saturation is based on the increasing prominence of the fourth chemical association rate constant, k-4, in the intermediate compound theory of Adair. It is known that k-4 is several times larger than any of the other three k–s. Submitted on December 19, 1960

Abstract 2470: Augmented Tonic Activation Of Chemoreceptors May Contribute To Sympathetic Overactivity In Patients With Essential Hypertension

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Maciej Sinski ◽  
Jacek Lewandowski ◽  
Joanna Bidiuk ◽  
Piotr Abramczyk ◽  
Anna Dobosiewicz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Sympathetic Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Arterial Blood ◽  
Hemoglobin Saturation ◽  
Ambient Oxygen ◽  
Young Subjects ◽  
End Tidal ◽  
Carotid Body Chemoreceptors

Rationale : Peripheral chemoreflex contributes to regulation of arterial blood pressure and chemoreceptors respond not only to hypoxia but they are also continuously activated by normal ambient oxygen concentration. Stimulation of chemoreceptors activates sympathetic traffic and this response may be altered in subjects with essential hypertension.. Objective: The aim of our study was to investigate the effect of deactivation of carotid body chemoreceptors on sympathetic activity directly measured as MSNA (muscle sympathetic nerve activity) in young subjects with mild to moderate untreated hypertension. Methods: Twelve patients with essential hypertension (36±9 years, all men, BMI 29±4 kg/m 2 ,) and 8 controls (37±7, men BMI 27±5kg/m 2 ) participated in the study. None of the patients or controls received any medications. MSNA (burst/minute and mean burst amplitude - au), systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate (HR), ECG, hemoglobin saturation with oxygen (Sat%), end tidal CO 2 and respiratory movements were monitored and measured after 10 minute of respiration by non-rebreathing mask with 100% 0 2 or 21% O 2 applied in blinded fashion. Results: Hypertensives had higher resting MSNA (38.6 ±8.6 burst/min vs. 30.3±.7 burst/min, p<0.05), SBP (149.1± 9.9 vs. 124.1 ±11.6, p < 0.05) and DBP (92.1 ±8.6 vs. 78.1 ± 8.9, p< 0.05) than controls. Breathing with 100% oxygen caused significant decrease in MSNA in hypertensives (from 38.6 ± 8.6 burst/min to 26.3 burst/min ± 6.8 and from 100 ± 0 au to 86 ± 18 au, p< 0.05) and no change in MSNA in controls (30.3 ± 5.7 burst/min initially and 27.3 burst/min ± 6.2 after 100% 0 2 , 100 ± 0 au vs. 98 ± 11 au). Blood pressure, end tidal CO 2 , respiration frequency did not change significantly after hyperoxia while HR decreased (from 69.6 ± 9 to 64.1 ± 7 in hypertensives p<0.05 and from 67± 8 to 62.5 ± 7 in controls, p< 0.05). Sat% increased significantly in both groups to 99%. Conclusions: Increased sympathetic activity in young, untreated hypertensives may be caused by the elevated tonic chemoreflex activation.

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