Effects of intense exercise training on plasma catecholamines in coronary patients

1984 ◽  
Vol 57 (1) ◽  
pp. 154-159 ◽  
Author(s):  
Ali A. Ehsani ◽  
Gregory W. Heath ◽  
Wade H. Martin ◽  
James M. Hagberg ◽  
John O. Holloszy
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Maximal Exercise ◽  
Plasma Catecholamines ◽  
Arterial Disease ◽  
Rate Pressure Product ◽  
Plasma Norepinephrine ◽  
Norepinephrine Level ◽  
Coronary Arterial Disease ◽  
Plasma Norepinephrine Level

This paper reports the effect of 12 mo of intense endurance exercise training on the plasma catecholamine response to exercise in 11 male patients [aged 50 ± 8 yr (mean ± SD)] with coronary artery disease. A substantial adaptation to training was attained as evidenced by a 42% increase in maximum O2uptake capacity. At rest, heart rate was lower after training, but resting blood pressure and plasma catecholamines were unchanged. At the same absolute work rate, plasma norepinephrine and epinephrine levels, rate pressure product, and ischemic S-T segment depression were all significantly lower aftertraining. A higher plasma norepinephrine level was attained at maximal exercise after training (2,049± 654 before vs. 3,408 ± 1,454 pg/ml after, P < 0.025); this was associated with a higher systolic blood pressure (175 ± 25 before vs. 188 ± 22 mmHg after, P < 0.025) and a higher rate-pressure product (25.3 x 103 ± 4.5 x 103 before vs. 27.6 x 103 ± 5.2 x 103 after, P < 0.025). Despite the higher plasma norepinephrine level and rate pressure product, S-T segment depression at maximal exercise was unchanged. These findings suggest that some patients with coronary arterial disease can attain a higher myocardial O2 requirement, without electrocardiographic evidence of increased ischemia, after prolonged strenuous exercise training. myocardial infarction; coronary arterial disease Submitted on July 5, 1983 Submitted on July 5, 1983

Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension

2006 ◽  
Vol 100 (2) ◽  
pp. 541-547 ◽  
Author(s):  
Patricia O. Reger ◽  
Mary F. Barbe ◽  
Mamta Amin ◽  
Brian F. Renna ◽  
Leigh Ann Hewston ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heat Shock ◽  
Exercise Training ◽  
Heat Shock Protein ◽  
Endurance Training ◽  
Left Ventricular ◽  
Treadmill Running ◽  
Rate Pressure Product ◽  
Protein Abundance ◽  
Myocardial Hypoperfusion

The purpose of this study was to examine whether exercise training, superimposed on compensated-concentric hypertrophy, could increase myocardial hypoperfusion-reperfusion (H/R) tolerance. Female Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) (age: 4 mo; N = 40) were placed into a sedentary (SED) or exercise training (TRD) group (treadmill running; 25 m/min, 1 h/day, 5 days/wk for 16 wk). Four groups were studied: WKY-SED ( n = 10), WKY-TRD ( n = 10), SHR-SED ( n = 10), and SHR-TRD ( n = 10). Blood pressure and heart rate were determined, and in vitro isolated heart performance was measured with a retrogradely perfused, Langendorff isovolumic preparation. The H/R protocol consisted of a 75% reduction in coronary flow for 17 min followed by 30 min of reperfusion. Although the rate-pressure product was significantly elevated in SHR relative to WKY, training-induced bradycardia reduced the rate-pressure product in SHR-TRD ( P < 0.05) without an attenuation in systolic blood pressure. Heart-to-body weight ratio was greater in both groups of SHR vs. WKY-SED ( P < 0.001). Absolute and relative myocardial tolerance to H/R was greater in WKY-TRD and both groups of SHR relative to WKY-SED ( P < 0.05). Endurance training superimposed on hypertension-induced compensated hypertrophy conferred no further cardioprotection to H/R. Postreperfusion 72-kDa heat shock protein abundance was enhanced in WKY-TRD and both groups of SHR relative to WKY-SED ( P < 0.05) and was highly correlated with absolute left ventricular functional recovery during reperfusion ( R2= 0.86, P < 0.0001). These data suggest that both compensated hypertrophy associated with short-term hypertension and endurance training individually improved H/R and that increased postreperfusion 72-kDa heat shock protein abundance was, in part, associated with the cardioprotective phenotype observed in this study.

A Comparative Study Between Efficacy Of Esmolol And Lignocaine For Attenuating Haemodynamics Response Due To Laryngoscopy And Endotracheal Intubation

1970 ◽  
Vol 5 (1) ◽  
pp. 25-28 ◽  
Author(s):  
M Begum ◽  
P Akter ◽  
MM Hossain ◽  
SMA Alim ◽  
UHS Khatun ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Endotracheal Intubation ◽  
Anaesthetic Management ◽  
Management Plan ◽  
Mean Blood Pressure ◽  
Rate Pressure Product ◽  
Plasma Norepinephrine ◽  
Mean Values ◽  
The Mean

Haemodynamic stability is an integral and essential goal of any anaesthetic management plan. Laryngoscopy and intubation can cause striking changes in haemodynamics. Increase in blood pressure and heart rate occurs most commonly from reflex sympathetic and vagal discharge in response to laryngotracheal stimulation, which in turn leads to increased plasma norepinephrine concentration. This study was designed to compare efficacy of esmolol and lignocaine for attenuating haemodynamics response due to laryngoscopy and endotracheal intubation. The aim of this study was to compare the effects of Esmolol with that of Lignocaine to attenuate the detrimental rise in heart rate and blood pressure during laryngoscopy and tracheal intubation. One hundred and twenty adult patients randomized into group-L and group-E, were received lignocaine 1.5 mg/kg and Esmolol 1.5 mg/kg I.V. respectively. Heart rate and blood pressure in each minutes for the 10 minutes after intubation was recorded. Time span around intubation up to 4 minutes has been looked specifically to isolate the effect of the study drugs at the time of intubation. For statistical analysis Student's 't' test was used for comparing means of quantitative data and chi-square test was used for qualitative data. Difference was considered statistically significant if p<0.05. The mean heart rate, systolic, diastolic, and mean blood pressure, and rate-pressure product before starting anesthesia were similar in group-L (Lignocaine group) and in group-E (Esmolol group) (p>0.05). The mean values of heart rate, systolic, diastolic, and mean blood pressure, and rate-pressure product at 2, 3 and 4 minutes after intubation were significantly lower in group-E than group-L (p<0.05). In conclusion, esmolol 1.5 mg/kg is superior to lignocaine (1.5 mg/kg) for attenuation of haemodynamic response to laryngoscopy and endotracheal intubation. Key words: Haemodynamics; heart rate; intubation; esmolol; lignocaine DOI: 10.3329/fmcj.v5i1.6810Faridpur Med. Coll. J. 2010;5(1):25-28

Elevated plasma norepinephrine level and sick sinus syndrome in patients with lone atrial fibrillation

Heart ◽  
2015 ◽  
Vol 101 (14) ◽  
pp. 1133-1138 ◽  
Author(s):  
Kentaro Yoshida ◽  
Takashi Kaneshiro ◽  
Yoko Ito ◽  
Akira Kimata ◽  
Naoya Koda ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sick Sinus Syndrome ◽  
Plasma Norepinephrine ◽  
Elevated Plasma ◽  
Norepinephrine Level ◽  
Lone Atrial Fibrillation ◽  
Plasma Norepinephrine Level

scholarly journals Effects of Various Stress on Plasma Norepinephrine Level

1980 ◽  
Vol 73 (2special) ◽  
pp. 515-522
Author(s):  
Jun-ichi Yoshida ◽  
Kunitoshi Yoshino ◽  
Toru Matsunaga ◽  
Yutaka Furukawa ◽  
Etsuko Tagami
Keyword(s):  
Plasma Norepinephrine ◽  
Norepinephrine Level ◽  
Plasma Norepinephrine Level

Atherosclerotic vascular diseases have really the same risk factors? Comparison between large abdominal aortic aneurysm and obstructive non-coronary arterial disease

Vascular ◽  
2017 ◽  
Vol 25 (6) ◽  
pp. 629-634 ◽  
Author(s):  
Dimitri Tsialtas ◽  
Maria Giulia Bolognesi ◽  
Riccardo Volpi ◽  
Roberto Bolognesi
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Vascular Diseases ◽  
Arterial Disease ◽  
Coronary Arterial Disease ◽  
Abdominal Aortic ◽  
Diastolic Hypertension ◽  
Clinical Conditions

Objectives The purpose of this study was to investigate whether there are differences among clinical conditions and traditional atherosclerotic risk factors between patients with large abdominal aortic aneurysm and those with occlusive non-coronary arterial disease. Methods We clinically examined 519 patients with asymptomatic abdominal aortic aneurysm and 672 with severe obstructive arterial diseases before surgical repair. Results In patients with abdominal aortic aneurysm, we identified a clear predominance of males ( p < 0.001), more alcohol consumers ( p < 0.05), higher values of diastolic blood pressure ( p < 0.05), higher values of serum creatinine ( p < 0.005), more hyperuricemic patients ( p < 0.005) and less diabetics ( p < 0.001). In patients with occlusive atherosclerotic vasculopathies, we observed more smokers ( p < 0.05), higher systolic blood pressure and more hypertensives ( p < 0.05 respectively) and a prevalence of hypertriglyceridemia ( p < 0.05). Conclusions Patients with abdominal aortic aneurysm were mostly males with diastolic hypertension, impaired renal function and less diabetics, while patients with occlusive arteriopathy were more smokers, hypertensives and more hypertriglyceridemics.

scholarly journals Successful Anesthetic Management of Pheochromocytoma in a Patient with Substantial Increase in Plasma Norepinephrine Level

2008 ◽  
Vol 28 (1) ◽  
pp. 122-127
Author(s):  
Kohei KAMIYA ◽  
Hiroko NUNOKAWA ◽  
Miwa FUKUMOTO ◽  
Tamie HOSHIKAWA ◽  
Mikiko YAMAKAWA ◽  
...  
Keyword(s):  
Anesthetic Management ◽  
Plasma Norepinephrine ◽  
Norepinephrine Level ◽  
Plasma Norepinephrine Level

Blood pressure and plasma catecholamines in acute and prolonged hypoxia: effects of local hypothermia

1999 ◽  
Vol 87 (6) ◽  
pp. 2053-2058 ◽  
Author(s):  
Inge-Lis Kanstrup ◽  
Troels Dirch Poulsen ◽  
Jesper Melchior Hansen ◽  
Lars Juel Andersen ◽  
Morten Heiberg Bestle ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sea Level ◽  
High Pressures ◽  
Acute Mountain Sickness ◽  
Plasma Catecholamines ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
Local Cooling ◽  
Local Hypothermia

This study measured the pressor and plasma catecholamine response to local hypothermia during adaptation to hypobaric hypoxia. Eight healthy men were studied at rest and after 10 and 45 min of local cooling of one hand and forearm as well as after 30 min of rewarming at sea level and again 24 h and 5 days after rapid, passive transport to high altitude (4,559 m). Acute mountain sickness scores ranged from 5 to 16 (maximal attainable score: 20) on the first day but were reduced to 0–8 by the fifth day. Systolic blood pressure, heart rate, and plasma epinephrine increased on day 1 at altitude compared with sea level but declined again on day 5, whereas diastolic and mean blood pressures continued to rise in parallel with plasma norepinephrine. With local cooling, an increased vasoactive response was seen on the fifth day at altitude. Very high pressures were obtained, and the pressure elevation was prolonged. Heart rate increased twice as much on day 5 compared with the other two occasions. Thoracic fluid index increased with cooling on day 5, suggesting an increase in pulmonary vascular resistance. In conclusion, prolonged hypoxia seems to elicit an augmented pressor response to local cooling in the systemic and most likely also the pulmonary circulation.

Plasma catecholamine responses to exercise after training with beta-adrenergic blockade

1990 ◽  
Vol 68 (2) ◽  
pp. 586-593 ◽  
Author(s):  
E. E. Wolfel ◽  
W. R. Hiatt ◽  
H. L. Brammell ◽  
V. Travis ◽  
L. D. Horwitz
Keyword(s):  
Exercise Training ◽  
Maximal Exercise ◽  
Submaximal Exercise ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
Adrenergic Blockade ◽  
Absolute Level ◽  
Beta Adrenergic ◽  
Exercise Training Program ◽  
Induced Changes

Exercise training has been shown to decrease plasma norepinephrine (NE) and epinephrine (EPI) levels during absolute levels of submaximal exercise, which may reflect alterations in sympathetic tone as a result of training. To determine if beta-adrenergic blockade altered these changes in the plasma concentration of catecholamines with exercise conditioning, we studied the effects of beta-adrenergic blockade on NE and EPI at rest and during exercise in 24 healthy, male subjects after a 6-wk exercise training program. The subjects were randomized to placebo (P), atenolol 50 mg twice daily (A), and nadolol 40 mg twice daily (N). There were no changes in resting NE and EPI compared with pretraining values in any subject group. During the same absolute level of submaximal exercise NE decreased in P and A but was unchanged in N, whereas EPI decreased only in P. At maximal exercise all three groups developed significant increases in NE after training that paralleled increases in systolic blood pressure. EPI at maximal exercise increased after training with N but was unchanged with P or A. These training-induced changes in plasma catecholamine levels were masked or blunted when the A and N groups were studied while still on medication after training. Thus beta-adrenergic blockade has important effects on adaptations of the sympathetic nervous system to training, especially during submaximal exercise.

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