scholarly journals Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction

2020 ◽  
Vol 129 (6) ◽  
pp. 1267-1276 ◽  
Author(s):  
Stephen M. Ratchford ◽  
Heather L. Clifton ◽  
D. Taylor La Salle ◽  
Ryan M. Broxterman ◽  
Joshua F. Lee ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Muscle Blood Flow ◽  
Cardiovascular Responses ◽  
Exercise Intolerance ◽  
Preserved Ejection Fraction ◽  
Handgrip Exercise ◽  
Vascular Dysregulation ◽  
Exercise Hyperemia ◽  
First Time

The current study identified, for the first time, an attenuation in exercising muscle blood flow during handgrip exercise in individuals with heart failure with preserved ejection fraction (HFpEF) compared with overweight individuals with hypertension, two of the most common comorbidities associated with HFpEF. These decrements in exercise hyperemia cannot be attributed to disease-related changes in central hemodynamics or endothelial function, providing additional evidence for disease-related vascular dysregulation, which may be a predominant contributor to exercise intolerance in individuals with HFpEF.

scholarly journals Determinants of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction

2015 ◽  
Vol 119 (6) ◽  
pp. 739-744 ◽  
Author(s):  
Mark J. Haykowsky ◽  
Corey R. Tomczak ◽  
Jessica M. Scott ◽  
D. Ian Paterson ◽  
Dalane W. Kitzman
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Ejection Fraction ◽  
Muscle Blood Flow ◽  
Exercise Intolerance ◽  
Healthy Controls ◽  
Preserved Ejection Fraction ◽  
Skeletal Muscle Function ◽  
Skeletal Morphology ◽  
Patients With Heart Failure

This mini-review summarizes the literature regarding the mechanisms of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction (HFREF and HFPEF, respectively). Evidence to date suggests that the reduced peak pulmonary oxygen uptake (pulm V̇o2) in patients with HFREF compared with healthy controls is due to both central (reduced convective O2 transport) and peripheral factors (impaired skeletal muscle blood flow, decreased diffusive O2 transport coupled with abnormal skeletal morphology, and metabolism). Although central and peripheral impairments also limit peak pulm V̇o2 in HFPEF patients compared with healthy controls, emerging data suggest that the latter may play a relatively greater role in limiting exercise performance in these patients. Unlike HFREF, currently there is limited evidence-based therapies that improve exercise capacity in HFPEF patients, therefore future studies are required to determine whether interventions targeted to improve peripheral vascular and skeletal muscle function result in favorable improvements in peak pulm and leg V̇o2 and their determinants in HFPEF patients.

scholarly journals Cardiovascular Responses to Dynamic Handgrip Exercise in Patients with Heart Failure with Preserved Ejection Fraction

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Stephen M. Ratchford ◽  
Heather L. Clifton ◽  
D Taylor La Salle ◽  
Ryan M. Broxterman ◽  
Joshua F. Lee ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Cardiovascular Responses ◽  
Preserved Ejection Fraction ◽  
Handgrip Exercise ◽  
Patients With Heart Failure

Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction

2021 ◽  
Vol 78 (11) ◽  
pp. 1166-1187
Author(s):  
Ambarish Pandey ◽  
Sanjiv J. Shah ◽  
Javed Butler ◽  
Dean L. Kellogg ◽  
Gregory D. Lewis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Ejection Fraction ◽  
Exercise Intolerance ◽  
Preserved Ejection Fraction

Exercise Intolerance in Heart Failure with Preserved Ejection Fraction

2021 ◽  
Vol 17 (3) ◽  
pp. 397-413
Author(s):  
Andrea Salzano ◽  
Mariarosaria De Luca ◽  
Muhammad Zubair Israr ◽  
Giulia Crisci ◽  
Mohamed Eltayeb ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Exercise Intolerance ◽  
Preserved Ejection Fraction

scholarly journals Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

2015 ◽  
Vol 8 (2) ◽  
pp. 286-294 ◽  
Author(s):  
Bishnu P. Dhakal ◽  
Rajeev Malhotra ◽  
Ryan M. Murphy ◽  
Paul P. Pappagianopoulos ◽  
Aaron L. Baggish ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Exercise Intolerance ◽  
Preserved Ejection Fraction

scholarly journals INFLAMMATION AND EXERCISE INTOLERANCE IN HEART FAILURE WITH PRESERVED EJECTION FRACTION

2020 ◽  
Vol 75 (11) ◽  
pp. 679
Author(s):  
Emily Lau ◽  
Shahrooz Zarbafian ◽  
Ruslan Ilyasovich ◽  
John Sbarbaro ◽  
Robyn Farrell ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Exercise Intolerance ◽  
Preserved Ejection Fraction

scholarly journals Clinical Utility of Exercise Training in Heart Failure with Reduced and Preserved Ejection Fraction

2015 ◽  
Vol 9 ◽  
pp. CMC.S21372 ◽  
Author(s):  
Muhammad Asrar Ul Haq ◽  
Cheng Yee Goh ◽  
Itamar Levinger ◽  
Chiew Wong ◽  
David L. Hare
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Ejection Fraction ◽  
Exercise Tolerance ◽  
Exercise Intolerance ◽  
Sufficient Evidence ◽  
Preserved Ejection Fraction ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

Reduced exercise tolerance is an independent predictor of hospital readmission and mortality in patients with heart failure (HF). Exercise training for HF patients is well established as an adjunct therapy, and there is sufficient evidence to support the favorable role of exercise training programs for HF patients over and above the optimal medical therapy. Some of the documented benefits include improved functional capacity, quality of life (QoL), fatigue, and dyspnea. Major trials to assess exercise training in HF have, however, focused on heart failure with reduced ejection fraction (HFREF). At least half of the patients presenting with HF have heart failure with preserved ejection fraction (HFPEF) and experience similar symptoms of exercise intolerance, dyspnea, and early fatigue, and similar mortality risk and rehospitalization rates. The role of exercise training in the management of HFPEF remains less clear. This article provides a brief overview of pathophysiology of reduced exercise tolerance in HFREF and heart failure with preserved ejection fraction (HFPEF), and summarizes the evidence and mechanisms by which exercise training can improve symptoms and HF. Clinical and practical aspects of exercise training prescription are also discussed.

scholarly journals Carotid Arterial Stiffness and Its Relationship to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction

Hypertension ◽  
2013 ◽  
Vol 61 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Dalane W. Kitzman ◽  
David M. Herrington ◽  
Peter H. Brubaker ◽  
J. Brian Moore ◽  
Joel Eggebeen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Arterial Stiffness ◽  
Ejection Fraction ◽  
Older Patients ◽  
Exercise Intolerance ◽  
Preserved Ejection Fraction ◽  
Patients With Heart Failure ◽  
Carotid Arterial
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