scholarly journals A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness

2017 ◽  
Vol 122 (3) ◽  
pp. 631-641 ◽  
Author(s):  
Matthew R. Ely ◽  
Steven A. Romero ◽  
Dylan C. Sieck ◽  
Joshua E. Mangum ◽  
Meredith J. Luttrell ◽  
...  
Keyword(s):  
Blood Flow ◽  
Creatine Kinase ◽  
Muscle Strength ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Strength Loss ◽  
Histamine Receptor ◽  
Delayed Onset ◽  
Markers Of Inflammation ◽  
Exercise Induced

Histamine contributes to elevations in skeletal muscle blood flow following exercise, which raises the possibility that histamine is an important mediator of the inflammatory response to exercise. We examined the influence of antihistamines on postexercise blood flow, inflammation, muscle damage, and delayed-onset muscle soreness (DOMS) in a model of moderate exercise-induced muscle damage. Subjects consumed either a combination of fexofenadine and ranitidine (blockade, n = 12) or nothing (control, n = 12) before 45 min of downhill running (−10% grade). Blood flow to the leg was measured before and throughout 120 min of exercise recovery. Markers of inflammation, muscle damage, and DOMS were obtained before and at 0, 6, 12, 24, 48, and 72 h postexercise. At 60 min postexercise, blood flow was reduced ~29% with blockade compared with control ( P < 0.05). Markers of inflammation were elevated after exercise (TNF-ɑ, IL-6), but did not differ between control and blockade. Creatine kinase concentrations peaked 12 h after exercise, and the overall response was greater with blockade (18.3 ± 3.2 kU·l−1·h−1) compared with control (11.6 ± 2.0 kU·l−1·h−1; P < 0.05). Reductions in muscle strength in control (−19.3 ± 4.3% at 24 h) were greater than blockade (−7.8 ± 4.8%; P < 0.05) and corresponded with greater perceptions of pain/discomfort in control compared with blockade. In conclusion, histamine-receptor blockade reduced postexercise blood flow, had no effect on the pattern of inflammatory markers, increased serum creatine kinase concentrations, attenuated muscle strength loss, and reduced pain perception following muscle-damaging exercise. NEW & NOTEWORTHY Histamine appears to be intimately involved with skeletal muscle during and following exercise. Blocking histamine’s actions during muscle-damaging exercise, via common over-the-counter antihistamines, resulted in increased serum creatine kinase, an indirect marker of muscle damage. Paradoxically, blocking histamine’s actions attenuated muscle strength loss and reduced perceptions of muscle pain for 72 h following muscle-damaging exercise. These results indicate that exercise-induced histamine release may have a broad impact on protecting muscle from exercise-induced damage.

scholarly journals Relationship between Eccentric-Exercise-Induced Loss in Muscle Function to Muscle Soreness and Tissue Hardness

Healthcare ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 96
Author(s):  
Andreas Konrad ◽  
Kazuki Kasahara ◽  
Riku Yoshida ◽  
Kaoru Yahata ◽  
Shigeru Sato ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Muscle Function ◽  
Muscle Soreness ◽  
Pain Threshold ◽  
Young Male ◽  
Eccentric Contraction ◽  
Strength Loss ◽  
Delayed Onset ◽  
Tissue Hardness ◽  
Exercise Induced

It is well-known that unusual exercise, especially eccentric contraction (ECC), could cause delayed-onset muscle soreness. However, the factors related to the loss of muscle strength and range of motion (ROM) caused by eccentrically damaged muscle, such as increases in muscle soreness, tissue hardness, and pain threshold, have not been investigated in detail. Thus, this study was conducted to investigate the factors related to the loss of muscle strength and ROM caused by eccentrically damaged muscle in a large sample. Fifty-six sedentary healthy young male volunteers were instructed to perform 60 repetitions of ECC exercise. The outcome variables were measured before and 48 h after the ECC exercise. The results showed that a decrease in ROM was correlated to an increase in tissue hardness, whereas a decrease in muscle strength was correlated to an increase in muscle soreness. Our results suggested that tissue hardness must be controlled for ROM loss, and muscle soreness must be controlled for muscle-strength loss.

scholarly journals El masaje en la prevención y tratamiento del dolor muscular tardío: una revisión sistemática actualizada

2019 ◽  
Vol 6 (3) ◽  
pp. 38
Author(s):  
R Candia Luján ◽  
RA Paredes Carrera ◽  
O Costa Moreira ◽  
KF Candia Sosa ◽  
JA De Paz Fernández
Keyword(s):  
Muscle Damage ◽  
Muscle Soreness ◽  
Web Of Science ◽  
Delayed Onset Muscle Soreness ◽  
Delayed Onset ◽  
Palabras Clave ◽  
Revisión Sistemática ◽  
Exercise Induced

El masaje es una de las terapias más utilizadas para aliviar el dolor muscular tardío (DMT). El objetivo del presente estudio fue determinar la efectividad del masaje en el tratamiento del DMT, para lo cual se llevó a cabo una revisión sistemática en las bases de datos, Pubmed, Scopus, SportDiscus, Web of Science y el buscador Google académico, usando las palabras clave delayed onset muscle soreness y exercise induced muscle damage combinado con massage. Se incluyeron en el estudio 23 artículos en los cuales el 78% mostró disminución del DMT mientras que en el restante 22% no hubo mejoras o bien empeoró. El análisis de los estudios permite concluir que el masaje es una terapia efectiva en el tratamiento del dolor muscular tardío.

scholarly journals Repeated Bout Effect Was More Expressed in Young Adult Males Than in Elderly Males and Boys

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Giedrius Gorianovas ◽  
Albertas Skurvydas ◽  
Vytautas Streckis ◽  
Marius Brazaitis ◽  
Sigitas Kamandulis ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Repeated Bout Effect ◽  
Adult Males ◽  
Elderly Males ◽  
Dependent Variables ◽  
Drop Jumps ◽  
Exercise Induced ◽  
Repeated Bout

This study investigated possible differences using the same stretch-shortening exercise (SSE) protocol on generally accepted monitoring markers (dependent variables: changes in creatine kinase, muscle soreness, and voluntary and electrically evoked torque) in males across three lifespan stages (childhood versus adulthood versus old age). The protocol consisted of 100 intermittent (30 s interval between jumps) drop jumps to determine the repeated bout effect (RBE) (first and second bouts performed at a 2-week interval). The results showed that indirect symptoms of exercise-induced muscle damage after SSE were more expressed in adult males than in boys and elderly males, suggesting that the muscles of boys and elderly males are more resistant to exercise-induced damage than those of adult males. RBE was more pronounced in adult males than in boys and elderly males, suggesting that the muscles of boys and elderly males are less adaptive to exercise-induced muscle damage than those of adult males.

Effect of branched-Chain Amino Acid Supplementation on Muscle Soreness following Exercise: A Meta-Analysis

2019 ◽  
Vol 89 (5-6) ◽  
pp. 348-356 ◽  
Author(s):  
Michael V. Fedewa ◽  
Steven O. Spencer ◽  
Tyler D. Williams ◽  
Zachery E. Becker ◽  
Collin A. Fuqua
Keyword(s):  
Amino Acid ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Delayed Onset Muscle Soreness ◽  
Control Group ◽  
Acute Bout ◽  
Delayed Onset ◽  
Branched Chain Amino Acid ◽  
Branched Chain ◽  
Exercise Induced

Abstract. Delayed onset muscle soreness (DOMS) is a symptom of exercise-induced muscle damage that occurs following exercise. Previous research has indicated that branched-chain amino acid (BCAA) supplementation may attenuate exercise-induced muscle damage that causes delayed onset muscle soreness, however the results are inconsistent. The primary aim of this study was to examine the previous literature assessing the effect of BCAA supplementation on DOMS following an acute bout of exercise in adults. This review was conducted in accordance with PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-analyses), and identified peer-reviewed articles comparing a BCAA supplement to a placebo non-BCAA supplement following an acute bout of exercise. An electronic search of three databases (EbscoHost, Web of Science, and SPORTDiscus) yielded 42 articles after duplicates were removed. All studies included in the current analyis were: 1) peer-reviewed publications; 2) available in English; 3) utilized a random control design that compared a BCAA group to a placebo control group following exercise; 4) and assessed soreness of muscle tissue during recovery. DOMS was assessed in 61 participants following ingestion of a BCAA supplement over the course of these interventions. The cumulative results of 37 effects gathered from 8 studies published between 2007 and 2017 indicated that BCAA supplementation reduced DOMS following exercise training (ES = 0.7286, 95% CI: 0.5017 to 0.9555, p < 0.001). A large decrease in DOMS occurs following BCAA supplementation after exercise compared to a placebo supplement.

scholarly journals Effects of caffeine and sex on muscle performance and delayed-onset muscle soreness after exercise-induced muscle damage: a double-blind randomized trial

2019 ◽  
Vol 127 (3) ◽  
pp. 798-805 ◽  
Author(s):  
Hou-Yu Chen ◽  
Yung-Chih Chen ◽  
Kang Tung ◽  
Hsiao-Han Chao ◽  
Ho-Seng Wang
Keyword(s):  
Muscle Damage ◽  
Muscle Soreness ◽  
Female Athletes ◽  
Muscle Power ◽  
Delayed Onset Muscle Soreness ◽  
Muscle Performance ◽  
Caffeine Ingestion ◽  
Male Athletes ◽  
Delayed Onset ◽  
Exercise Induced

The present study aims to investigate effects of caffeine ingestion and sex difference on muscle performance, delayed-onset muscle soreness (DOMS), and various biomarkers under exercise-induced muscle damage (EIMD). Twenty (10 male and 10 female) healthy elite college athletes were recruited. Participants ingested either caffeine (6 mg/kg) or a placebo in a randomized, double-blind, and counterbalanced fashion at 24 and 48 h following EIMD. Muscle performance, DOMS, and blood samples were taken an hour before and an hour after supplementation. Caffeine ingestion restored impaired maximal voluntary isometric contractions (MVIC: 10.2%; MVICpost: 7.2%, both P < 0.05) during EIMD across both sexes. Following caffeine ingestion during MVIC, while affected by EIMD, an interaction was found in DOMS and serum K+ (both P < 0.05), with males showing greater attenuation (21.5 and 16.9%, respectively) compared with females (4.6 and 1.3%, respectively). DOMS demonstrated an inverse correlation with MVIC after caffeine ingestion both overall and among male athletes ( r = −0.34 and −0.54, respectively; P < 0.05) but not among female athletes ( r = −0.11; P > 0.05) under EIMD. In addition, caffeine ingestion increased postexercise serum glucose and lactate concentrations across both sexes (both P < 0.05). This is the first study to show that male athletes, compared with female athletes, experience a greater reduction in DOMS during enhanced MVIC when caffeine was consumed, suggesting men might receive greater ergogenic effects from caffeine when affected by EIMD. Furthermore, caffeine ingestion was able to restore impaired muscle power among elite collegiate athletes across both sexes. NEW & NOTEWORTHY Exercise-induced muscle damage (EIMD) reduces anaerobic/aerobic performance and increases delayed-onset muscle soreness (DOMS) during exercise. We show that acute caffeine supplementation at a dosage of 6 mg/kg seems to facilitate recovery of anaerobic muscle power and attenuate DOMS after EIMD across both sexes. Furthermore, male athletes, compared with female athletes, when caffeine was prescribed, experience a greater reduction in DOMS with better restoration of impaired maximal voluntary isometric contractions. This suggests that male athletes might benefit from the ergogenic effect of acute caffeine supplementation after the onset of EIMD.

EFFECTS OF A PROTEASE SUPPLEMENT ON ECCENTRIC EXERCISE-INDUCED MARKERS OF DELAYED-ONSET MUSCLE SORENESS AND MUSCLE DAMAGE

2007 ◽  
Vol 21 (3) ◽  
pp. 661-667 ◽  
Author(s):  
TRAVIS W. BECK ◽  
TERRY J. HOUSH ◽  
GLEN O. JOHNSON ◽  
RICHARD J. SCHMIDT ◽  
DONA J. HOUSH ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Soreness ◽  
Delayed Onset Muscle Soreness ◽  
Delayed Onset ◽  
Exercise Induced

scholarly journals Effects of Far‐Infrared Emitting Ceramic Material Clothing on Recovery After Maximal Eccentric Exercise

2019 ◽  
Vol 70 (1) ◽  
pp. 135-144
Author(s):  
Renan Felipe Hartmann Nunes ◽  
Naiandra Dittrich ◽  
Rob Duffield ◽  
Marília Cavalcante Serpa ◽  
Tiago Martins Coelho ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Soreness ◽  
Far Infrared ◽  
Ceramic Materials ◽  
Voluntary Contraction ◽  
Delayed Onset Muscle Soreness ◽  
Delayed Onset

Abstract The purpose of this study was to determine whether Far-Infrared Emitting Ceramic Materials worn as Bioceramic pants would improve neuromuscular performance, biochemical and perceptual markers in healthy individuals after maximal eccentric exercise. Twenty-two moderately active men were randomized into Bioceramic (n = 11) or Placebo (n = 11) groups. To induce muscle damage, three sets of 30 maximal isokinetic eccentric contractions of the quadriceps were performed at 60°·s-1. Participants wore the bioceramic or placebo pants for 2 hours immediately following the protocol, and then again for 2 hours prior to each subsequent testing session at 24, 48 and 72 hours post. Plasma creatine kinase and lactate dehydrogenase activity, delayed-onset muscle soreness, perceived recovery status, and maximal voluntary contraction were measured pre-exercise and 2, 24, 48, and 72 hours post-exercise. Eccentric exercise induced muscle damage as evident in significant increases in delayed-onset muscle soreness at 24 - 72 hours (p < 0.05) and creatine kinase between Pre to 2, 24, 48 and 72 hours (p < 0.05). Despite the increased delayed-onset muscle soreness and creatine kinase values, no effect of Bioceramic was evident (p > 0.05). Furthermore, decreases in maximal voluntary contraction between Pre and immediately, 2, 24, 48 and 72 hours post (p < 0.05) were reported. However, the standardized difference was moderate lower for lactate dehydrogenase at 24 h (ES = 0.50), but higher at 48 h (ES = -0.58) in the Bioceramic compared to the Placebo group. Despite inducing muscle damage, the daily use of Far-Infrared Emitting Ceramic Materials clothing over 72 hours did not facilitate recovery after maximal eccentric exercise.

scholarly journals THE EFFECT OF DIFFERENT DOSE OF DROP JUMPING ON SYMPTOMS OF MUSCLE DAMAGE

2018 ◽  
Vol 1 (108) ◽  
pp. 25-29
Author(s):  
Albertas Skurvydas ◽  
Gediminas Mamkus ◽  
Dalia Mickevičienė ◽  
Diana Karanauskienė ◽  
Dovilė Valančienė ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Knee Extension ◽  
Cycle Exercise ◽  
Healthy Men ◽  
Maximal Intensity ◽  
Drop Jumps ◽  
Stretch Shortening Cycle ◽  
Exercise Induced

Background. The aim of this study was to follow symptoms of exercise induced muscle damage in response to 50, 100 and 200 drop jumps with maximal intensity. Methods. Three groups of young healthy men (n = 10 in each group) performed a bout of mechanically demanding stretch shortening cycle exercise consisting of 50, 100 and 200 drop jumps. Voluntary and electrically induced knee extension torque, creatine kinase, muscle soreness were measured before and 24 h after exercise. Results. Indirect symptoms of exercise induced damage were dependent on DJs volume: the higher the numbers of jumps, the more symptoms were observed. Only after 200 DJs compared to 50-100 DJ there was decrease of CAR and H of DJ, and 24 h after 200 DJs CK was greater than after 50-100 DJs. Conclusion. In response to acute severe muscle-damaging exercise (after 200 DJs), indirect symptoms of exercise-induced muscle damage occurred.

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