scholarly journals Na+-K+-ATPase α2-gene and skeletal muscle characteristics in response to long-term overfeeding

2003 ◽  
Vol 94 (5) ◽  
pp. 1870-1874 ◽  
Author(s):  
Olavi Ukkola ◽  
Denis R. Joanisse ◽  
Angelo Tremblay ◽  
Claude Bouchard
Keyword(s):  
Skeletal Muscle ◽  
Fat Mass ◽  
Low Density Lipoprotein ◽  
Monozygotic Twins ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Total Fat ◽  
Metabolic Properties

The role of Na+-K+-ATPase α2-gene BglII polymorphism in the changes of skeletal muscle metabolic properties after a 100-day overfeeding protocol conducted with 12 pairs of monozygotic twins is reported. The activities of oxoglutarate dehydrogenase (OGDH) and phosphofructokinase (PFK) were determined from muscle biopsies. A larger increase in the total fat mass (127 vs. 61%) ( P < 0.05) and low-density lipoprotein cholesterol (20 vs. 0.7%) ( P = 0.05) in 8.0/8.0-kb [3.3-kb negative (−); n = 7 pairs] than in 8.0/3.3 + 3.3/3.3-kb [3.3-kb positive (+); n = 5 pairs] subjects was observed. OGDH activity decreased in 3.3-kb− (−15%), whereas PFK (+26%) as well as the PFK-to-OGDH ratio (90%) increased. In contrast, among 3.3-kb+, OGDH increased (+54%) together with a decrease in PFK (−1%) and PFK-to-OGDH ratio (−5%). These changes were significantly different between genotypes ( Pfrom <0.05 to 0.01). In conclusion, fat mass, low-density lipoprotein cholesterol, and skeletal muscle glycolytic-to-oxidative enzyme ratio increased more in the α2-gene 3.3-kb− subjects with overfeeding, suggesting more unfavorable metabolic changes compared with the 3.3-kb+ subjects.

Association of muscle mass and fat mass on low-density-lipoprotein cholesterol and triglyceride plasma concentration in children and adolescents

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Kyriakos Martakis ◽  
Christina Stark ◽  
Mirko Rehberg ◽  
Miriam Jackels ◽  
Eckhard Schoenau ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Children And Adolescents ◽  
Muscle Mass ◽  
Fat Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Triglyceride Concentration

Abstract Objectives Obesity has often been associated with high low-density-lipoprotein cholesterol (LDL-C) and triglyceride plasma concentrations, known risk factors for diabetes mellitus and cardiovascular disease. Study objective was to evaluate the association of LDL-C and triglyceride plasma concentration with muscle and fat mass in children and adolescents. Methods We analyzed data of the National Health and Nutrition Examination Survey (1999–2004) to estimate lean muscle and fat mass assessed by dual-energy X-ray absorptiometry (DXA) of participants whose lipid profiles had been examined. Fat mass was operationalized by DXA-determined fat mass index (FMI). Muscle mass was assessed by appendicular lean mass index (aLMI). High LDL-C and triglyceride concentration was defined as above 130 mg/dL. Results For the evaluation of the association of LDL-C and triglyceride plasma concentration with LMI and FMI Z-scores, the data of 2,487 children and adolescents (age 8–19 years) (984 females) were eligible. High aLMI showed no association with LDL-C or triglyceride concentration, but high FMI showed significant association with LDL-C and triglyceride plasma concentration in the bivariate regression analysis. Conclusions Isolated muscle mass increase may not be protective against high LDL-C and triglycerides plasma levels in children and adolescents. Thus, exercise may lead to risk factor reduction mainly through fat mass reduction.

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