Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate corter

2021 ◽  
Author(s):  
Ying Xiao ◽  
Lei Xie ◽  
Qi-Ya Xu ◽  
Li Chen ◽  
Huan Chen ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Analgesic Effect ◽  
Underlying Mechanism ◽  
Pharmacological Therapy ◽  
Visceral Hypersensitivity ◽  
Anterior Cingulate ◽  
Direct Current Stimulation ◽  
Colorectal Distention ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is one of the most common clinical diseases with treatment for which being challenging. The aim of this study is to investigate whether transcranial direct current stimulation (tDCS) has analgesic effect on visceral hypersensitivity (VH) in an animal model of IBS as well as the underlying mechanism. Since the activation of GluN2B in anterior cingulate cortex (ACC) takes part in VH, we examined whether and how GluN2B in ACC take part in the effect of tDCS. Neonatal maternal deprivation (NMD), a valuable experimental model to study the IBS pathophysiology, was used to induce visceral hypersensitivity of rats. We quantified VH as colorectal distention threshold and performed patch clamp recordings of ACC neurons. The expression of GluN2B were determined by RT-qPCR and western blotting. The GluN2B antagonist Ro 25-6981 was microinjected into the rostral and caudal ACC. tDCS was performed for 7 consecutive days. It was found that NMD decreased expression of GluN2B, which could be obviously reversed by tDCS. Injection of Ro 25-6981 into rostral and caudal ACC of normal rats induced VH and also reversed the analgesic effect of tDCS. Our data sheds light on the non-pharmacological therapy for chronic VH in pathological states such as IBS.

Additive Analgesic Effect of Transcranial Direct Current Stimulation Together with Mirror Therapy for the Treatment of Phantom Pain

Pain Medicine ◽  
2020 ◽  
Author(s):  
Nitza Segal ◽  
Dorit Pud ◽  
Hagai Amir ◽  
Motti Ratmansky ◽  
Pora Kuperman ◽  
...  
Keyword(s):  
Treatment Group ◽  
Pain Intensity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Analgesic Effect ◽  
Secondary Outcome ◽  
Mcgill Pain Questionnaire ◽  
Phantom Pain ◽  
Mirror Therapy ◽  
Direct Current Stimulation

Abstract Objective Current analgesic treatments for phantom pain are not optimal. One well-accepted yet limited nonpharmacological option is mirror therapy, which is thought to counterbalance abnormal plasticity. Transcranial direct current stimulation (tDCS) is an emerging approach believed to affect the membrane potential and activity threshold of cortical neurons. tDCS analgesic effectiveness, however, is mild and short, rendering it a noneffective stand-alone treatment. This study aimed to assess if a combination of mirror therapy with tDCS results in a superior analgesic effect as compared with mirror therapy alone in patients suffering from phantom pain due to recent amputation. Design Following ethical approval, eligible patients provided informed consent and were randomly assigned to a study treatment group that continued for 2 weeks (once daily): 1) mirror therapy; 2) mirror therapy and sham tDCS; or 3) mirror therapy and tDCS. Assessments were done before treatment; at the end of treatment weeks 1 and 2; and at 1 week, 1 month, and 3 months following treatment. The primary outcome measure was pain intensity. Secondary measures were derived from the Short Form McGill Pain Questionnaire and the Brief Pain Inventory. Results Thirty patients were recruited, and 29 patients completed the study. Three months following treatment, pain intensity was significantly (P<0.001) reduced in the combined treatment group (reduction of 5.4±3.3 points) compared with the other study arms (mirror therapy, 1.2±1.1; mirror therapy and sham tDCS, 2.7±3.2). All secondary outcome results were in line with these findings. Conclusions Combining tDCS with mirror therapy results in a robust long-lasting analgesic effect. These encouraging findings may contribute to the understanding of the underlying mechanisms of phantom pain.

scholarly journals Effects of Transcranial Direct Current Stimulation on Neural Networks in Young and Older Adults

2017 ◽  
Vol 29 (11) ◽  
pp. 1817-1828 ◽  
Author(s):  
Andrew K. Martin ◽  
Marcus Meinzer ◽  
Robert Lindenberg ◽  
Mira M. Sieg ◽  
Laura Nachtigall ◽  
...  
Keyword(s):  
Older Adults ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Age Groups ◽  
Anterior Cingulate ◽  
Semantic Fluency ◽  
Motor Speech ◽  
Word Generation ◽  
Direct Current Stimulation ◽  
Components Analysis

Transcranial direct current stimulation (tDCS) may be a viable tool to improve motor and cognitive function in advanced age. However, although a number of studies have demonstrated improved cognitive performance in older adults, other studies have failed to show restorative effects. The neural effects of beneficial stimulation response in both age groups is lacking. In the current study, tDCS was administered during simultaneous fMRI in 42 healthy young and older participants. Semantic word generation and motor speech baseline tasks were used to investigate behavioral and neural effects of uni- and bihemispheric motor cortex tDCS in a three-way, crossover, sham tDCS controlled design. Independent components analysis assessed differences in task-related activity between the two age groups and tDCS effects at the network level. We also explored whether laterality of language network organization was effected by tDCS. Behaviorally, both active tDCS conditions significantly improved semantic word retrieval performance in young and older adults and were comparable between groups and stimulation conditions. Network-level tDCS effects were identified in the ventral and dorsal anterior cingulate networks in the combined sample during semantic fluency and motor speech tasks. In addition, a shift toward enhanced left laterality was identified in the older adults for both active stimulation conditions. Thus, tDCS results in common network-level modulations and behavioral improvements for both age groups, with an additional effect of increasing left laterality in older adults.

Long-lasting analgesic effect of transcranial direct current stimulation in treatment of chronic endometriosis pain

2015 ◽  
Vol 41 (12) ◽  
pp. 1998-2001 ◽  
Author(s):  
Reza Rostami ◽  
Bashar W. Badran ◽  
Reza Kazemi ◽  
Mohammad Habibnezhad ◽  
Mark S. George
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Analgesic Effect ◽  
Direct Current Stimulation

Targeting the anterior cingulate with bipolar and high-definition transcranial direct current stimulation

Neuroreport ◽  
2020 ◽  
Vol 31 (4) ◽  
pp. 346-351 ◽  
Author(s):  
Navneet Kaur ◽  
Ethan T. Whitman ◽  
Amelia D. Moser ◽  
Cecilia A. Hinojosa ◽  
Michael B. VanElzakker ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Anterior Cingulate ◽  
High Definition ◽  
Direct Current Stimulation

Preconditioning Prefrontal Connectivity Using Transcranial Direct Current Stimulation and Transcranial Magnetic Stimulation

2022 ◽  
Author(s):  
Isabel Alkhasli ◽  
Felix M. Mottaghy ◽  
Ferdinand Binkofski ◽  
Katrin Sakreida
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Functional Connectivity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Magnetic Stimulation ◽  
Anterior Cingulate ◽  
Caudate Nuclei ◽  
Direct Current Stimulation ◽  
Resting Motor Threshold

Abstract Transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) have been shown to modulate functional connectivity. Their specific effects seem to be dependent on the pre-existing neuronal state. We aimed to precondition frontal networks using tDCS and subsequently stimulate the left dorsolateral prefrontal cortex (lDLPFC) using TMS. Thirty healthy participants underwent either excitatory, inhibitory or sham tDCS for 10 min, as well as an excitatory intermittent theta burst (iTBS) protocol (600 pulses in 190 s, 20 x 2 s trains), applied over the lDLPFC at 90% of the individual resting motor threshold. Functional connectivity was measured in three task-free, 10-min-long baseline resting state fMRI sessions, immediately before and after tDCS, as well as after iTBS. Connectivity analyses between stimulation site and all other brain voxels, contrasting the interaction effect between the experimental tDCS groups (excitatory vs inhibitory) and the repeated measure (post tDCS vs. post TMS), revealed significantly affected voxels bilaterally in the anterior cingulate and paracingulate gyri, the caudate nuclei, the insula and operculum cortices, as well as the Heschl’s gyrus. ROI-to-ROI analyses additionally showed temporo-parietal-striatal and temporo-parietal-fronto-cingulate differences between the anodal and cathodal group post tDCS, as well as striatal-temporo-parietal anodal-cathodal differences and frontostriatal cathodal-sham group differences post TMS. Excitatory iTBS to a tDCS-inhibited lDLPFC yielded stronger functional connectivity to various areas, as compared to excitatory iTBS to a tDCS-enhanced prefrontal cortex. Results demonstrate complex, whole-brain stimulation effects, most-likely facilitated by cortical homeostatic control mechanisms, as well as the feasibility of using tDCS to modulate TMS effects.

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