Pulmonary Edema Fluid Clearance Pathways

Physiology ◽  
1995 ◽  
Vol 10 (3) ◽  
pp. 107-111
Author(s):  
R. E. Drake ◽  
J. C. Gabel
Keyword(s):  
Pulmonary Edema ◽  
Lung Tissue ◽  
Lymphatic Vessels ◽  
Edema Fluid

Lymphatic vessels normally remove excess fluid from the lung tissue and thus prevent pulmonary edema. However, when lungs do become edematous, the edema fluid may be cleared via several pathways. Each clearance pathway has unique properties, and recent studies have helped to define those properties.

Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome

Inflammation ◽  
1992 ◽  
Vol 16 (5) ◽  
pp. 509-517 ◽  
Author(s):  
Roger F. Espiritu ◽  
Jean -Francois Pittet ◽  
Michael A. Matthay ◽  
Edward J. Goetzl
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Pulmonary Edema ◽  
Adult Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Edema Fluid

Edema Fluid and Coagulation Changes During Fulminant Pulmonary Edema

CHEST Journal ◽  
1981 ◽  
Vol 79 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Richard W. Carlson ◽  
Richard C. Schaeffer ◽  
Moises Carpio ◽  
Max Harry Weil
Keyword(s):  
Pulmonary Edema ◽  
Edema Fluid

Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema

1999 ◽  
Vol 87 (4) ◽  
pp. 1301-1312 ◽  
Author(s):  
G. M. Verghese ◽  
L. B. Ware ◽  
B. A. Matthay ◽  
M. A. Matthay
Keyword(s):  
Pulmonary Edema ◽  
Fluid Transport ◽  
Simplified Acute Physiology Score ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Alveolar Fluid Clearance ◽  
Ventricular Ejection Fraction ◽  
Mechanically Ventilated ◽  
Alveolar Epithelial ◽  
Edema Fluid

To characterize the rate and regulation of alveolar fluid clearance in the uninjured human lung, pulmonary edema fluid and plasma were sampled within the first 4 h after tracheal intubation in 65 mechanically ventilated patients with severe hydrostatic pulmonary edema. Alveolar fluid clearance was calculated from the change in pulmonary edema fluid protein concentration over time. Overall, 75% of patients had intact alveolar fluid clearance (≥3%/h). Maximal alveolar fluid clearance (≥14%/h) was present in 38% of patients, with a mean rate of 25 ± 12%/h. Hemodynamic factors (including pulmonary arterial wedge pressure and left ventricular ejection fraction) and plasma epinephrine levels did not correlate with impaired or intact alveolar fluid clearance. Impaired alveolar fluid clearance was associated with a lower arterial pH and a higher Simplified Acute Physiology Score II. These factors may be markers of systemic hypoperfusion, which has been reported to impair alveolar fluid clearance by oxidant-mediated mechanisms. Finally, intact alveolar fluid clearance was associated with a greater improvement in oxygenation at 24 h along with a trend toward shorter duration of mechanical ventilation and an 18% lower hospital mortality. In summary, alveolar fluid clearance in humans may be rapid in the absence of alveolar epithelial injury. Catecholamine-independent factors are important in the regulation of alveolar fluid clearance in patients with severe hydrostatic pulmonary edema.

scholarly journals Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset

2017 ◽  
Vol 312 (5) ◽  
pp. L703-L709 ◽  
Author(s):  
Angela J. Rogers ◽  
Kévin Contrepois ◽  
Manhong Wu ◽  
Ming Zheng ◽  
Gary Peltz ◽  
...  
Keyword(s):  
Pulmonary Edema ◽  
Metabolic Profiling ◽  
Metabolic Profile ◽  
Principal Component ◽  
Distinct Group ◽  
Multivariate Statistical ◽  
Clinical Criteria ◽  
Edema Fluid ◽  
Biological Heterogeneity ◽  
Physiological Heterogeneity

There is considerable biological and physiological heterogeneity among patients who meet standard clinical criteria for acute respiratory distress syndrome (ARDS). In this study, we tested the hypothesis that there exists a subgroup of ARDS patients who exhibit a metabolically distinct profile. We examined undiluted pulmonary edema fluid obtained at the time of endotracheal intubation from 16 clinically phenotyped ARDS patients and 13 control patients with hydrostatic pulmonary edema. Nontargeted metabolic profiling was carried out on the undiluted edema fluid. Univariate and multivariate statistical analyses including principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were conducted to find discriminant metabolites. Seven-hundred and sixty unique metabolites were identified in the pulmonary edema fluid of these 29 patients. We found that a subset of ARDS patients (6/16, 38%) presented a distinct metabolic profile with the overrepresentation of 235 metabolites compared with edema fluid from the other 10 ARDS patients, whose edema fluid metabolic profile was indistinguishable from those of the 13 control patients with hydrostatic edema. This “high metabolite” endotype was characterized by higher concentrations of metabolites belonging to all of the main metabolic classes including lipids, amino acids, and carbohydrates. This distinct group with high metabolite levels in the edema fluid was also associated with a higher mortality rate. Thus metabolic profiling of the edema fluid of ARDS patients supports the hypothesis that there is considerable biological heterogeneity among ARDS patients who meet standard clinical and physiological criteria for ARDS.

The Effects of Rhodiola Tibetica on Lung Tissue of Rats with High Altitude Pulmonary Edema

2013 ◽  
Vol 690-693 ◽  
pp. 1305-1309
Author(s):  
Wen Hua Li
Keyword(s):  
Pulmonary Edema ◽  
High Altitude ◽  
Lung Tissue ◽  
Acute Hypoxia ◽  
Tibetan Medicine ◽  
Control Group ◽  
Rt Pcr ◽  
Oxygen Control ◽  
Hypoxia Group ◽  
High Altitude Pulmonary Edema

Objective observation of Tibetan medicine rhodiola on high altitude Pulmonary edema in rats and HIF-1a expression changes. Method Will 50 only male SD rats randomly divided into 5 group , are often oxygen control group (Xi'an , altitude 5m ), acute hypoxia control group (Xi'an , altitude 5m ), acute hypoxia Group (naqu , elevation 4500m ), rhodiola acclimatization control group ( Xi'an , altitude 5m ), rhodiola altitude acclimatization group (naqu, elevation 4500m ) , light and electron microscopic observation of lung tissue samples , immunohistochemical detection of various groups of lung tissue HIF-la expression, RT-PCR method detection altitude hypoxia group animal lungs HIF-la mRNA expression changes. Results Acute hypoxia group lung tissue microstructure and Ultrastructure of a discernible high altitude pulmonary edema, and after the Tibetan medicine rhodiola after high altitude pulmonary edema is significantly reduced, ( as in Figure 123456). Lung tissue within the immunohistochemical detection not see HIF-la protein expression, RT-PCR detection SD big rat intraperitoneal injection of rhodiola extract 40g BGE/kg, 2h open back began to rise 4h, peak, after declining 24h, basically back to their normal control group , level rhodiola medicine acclimatization group HIF a 1 am RNA expression are clearly higher than the atmospheric oxygen control group and acute hypoxia group (p < 0.01). Conclusions Tibetan medicine rhodiola on lung tissue HIF-lamRNA expression of conducive to reduce hypoxic rats high altitude pulmonary edema.

Lung Tissue and Airway Impedances during Pulmonary Edema in the Normal Range of Breathing

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A1423 ◽  
Author(s):  
J. Sprung ◽  
G. M. Barnas ◽  
R. Kahn ◽  
P. A. Delaney
Keyword(s):  
Pulmonary Edema ◽  
Lung Tissue ◽  
Normal Range

scholarly journals Inactivation of Exogenous Surfactant by Pulmonary Edema Fluid

1991 ◽  
Vol 29 (4) ◽  
pp. 353-356 ◽  
Author(s):  
Tsutomu Kobayashi ◽  
Keiko Nitta ◽  
Masaya Ganzuka ◽  
Sachiko Inui ◽  
Gertie Grossmann ◽  
...  
Keyword(s):  
Pulmonary Edema ◽  
Exogenous Surfactant ◽  
Edema Fluid
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