scholarly journals The Effect of Propofol on the Canine Sphincter of Oddi

HPB Surgery ◽  
1994 ◽  
Vol 7 (4) ◽  
pp. 297-304 ◽  
Author(s):  
T. H. Baron ◽  
C. B. Dalton ◽  
P. B. Cotton ◽  
G. R. May ◽  
L. G. Milton ◽  
...  
Keyword(s):  
Phase I ◽  
Motor Function ◽  
Sphincter Of Oddi ◽  
Migrating Motor Complex ◽  
Pressure Amplitude ◽  
Low Doses ◽  
Basal Pressure ◽  
Motor Complex ◽  
Single Lumen

To assess the effect of propofol on the canine sphincter of Oddi (SO), sphincter of Oddi manometry (SOM) was performed in fasting dogs which had undergone cholecystectomy and placement of modified Thomas duodenal cannulae. Using two water-perfused, single-lumen manometric catheters, SO and duodenal pressures were measured simultaneously. Baseline SO activity was recorded for at least one complete interdigestive cycle followed by bolus injections of propofol (Diprivan ®) (N = 31) from 0.1 to 4.0 mg/kg during Phase I of the Migrating Motor Complex (MMC).When propofol was administered in bolus doses ≤ 0.5 mg/kg, no change in SO or duodenal motor function was seen. In doses ≥ 0.5 mg/kg, SO basal pressure, amplitude, and frequency of contractions increased significantly. Increases in duodenal activity paralleled SO activity. Our results suggest that propofol in low doses may be useful for sedation during Sphincter of Oddi manometry in humans. Further studies of the effects of propofol on the human sphincter of Oddi are warranted.

Effect of insulin-induced hypoglycaemia on antral, pyloric and duodenal motility in fasting subjects

1991 ◽  
Vol 81 (2) ◽  
pp. 281-285 ◽  
Author(s):  
R. Fraser ◽  
J. Fuller ◽  
M. Horowitz ◽  
J. Dent
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Phase I ◽  
Blood Glucose Concentration ◽  
Migrating Motor Complex ◽  
Control Group ◽  
Motor Complex ◽  
Significant Difference ◽  
Interdigestive Migrating Motor Complex ◽  
Pyloric Motility

1. Hyperglycaemia alters gastric motility and delays gastric emptying. By contrast, there is little information regarding the effect of sub-normal blood glucose concentrations on gastric and, in particular, pyloric motility, although limited data suggest that hypoglycaemia is associated with accelerated gastric emptying despite an apparently increased basal pyloric pressure. 2. To determine the effects of hypoglycaemia on pyloric motility, we compared the effects of an intravenous injection of insulin (0.15 units/kg) with those of a placebo injection of saline in eight healthy human volunteers during phase I of the interdigestive migrating motor complex. 3. All subjects developed profound hypoglycaemia (mean blood glucose concentration 1.6 mmol/l compared with 4.0 mmol/l in the control group). 4. There was no significant difference in the number of antral (9 versus 7, P = 0.34), pyloric (3 versus 0, P = 0.31) or duodenal (21 versus 13, P = 0.42) pressure waves or in the basal pyloric pressure (0.3 mmHg versus 0.1 mmHg, P = 0.37) in the 45 min after insulin injection (hypoglycaemia) when compared with the 45 min after saline injection (euglycaemia). In both the euglycaemic and hypoglycaemic studies there was a time-dependent increase in the numbers of antral and duodenal waves consistent with the expected changes in the interdigestive migrating motor complex. 5. These results indicate that insulin-induced hypoglycaemia has no significant effect on pyloric motility during phase I of the interdigestive migrating motor complex.

Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans

2018 ◽  
Vol 63 (12) ◽  
pp. 3425-3433
Author(s):  
Byung Moo Yoo ◽  
Jin Hong Kim ◽  
Min Jae Yang ◽  
Glen A. Lehman ◽  
Jae Chul Hwang ◽  
...  
Keyword(s):  
Small Bowel ◽  
Sphincter Of Oddi ◽  
Migrating Motor Complex ◽  
Cyclic Change ◽  
Motor Complex ◽  
Sphincter Of Oddi Motility

Pancreaticobiliary Juice Releases Motilin during Phase I of the Migrating Motor Complex in Man

1993 ◽  
Vol 28 (1) ◽  
pp. 80-84 ◽  
Author(s):  
I. Nilsson ◽  
T. Svenberg ◽  
P. M. Hellström ◽  
E. Theodorsson ◽  
G. Hedenborg ◽  
...  
Keyword(s):  
Phase I ◽  
Migrating Motor Complex ◽  
Motor Complex

Tu1984 Hydroxy a-Sanshool, a Major Ingredient of TU-100 (Daikenchuto), Augments Migrating Motor Complex of Proximal Colon Triggered by Other Prokinetic Stimuli

2012 ◽  
Vol 142 (5) ◽  
pp. S-893
Author(s):  
Kunitsugu Kubota ◽  
Katsuya Ohbuchi ◽  
Nobuhiro Ohtake ◽  
Masahiro Yamamoto ◽  
Yuka Sudo ◽  
...  
Keyword(s):  
Proximal Colon ◽  
Migrating Motor Complex ◽  
Motor Complex

Relationship of plasma motilin concentration to fat ingestion, duodenal acidification and alkalinization, and migrating motor complexes in dogs

1981 ◽  
Vol 59 (2) ◽  
pp. 180-187 ◽  
Author(s):  
J. E. T. Fox ◽  
N. S. Track ◽  
E. E. Daniel
Keyword(s):  
Species Difference ◽  
Maximal Activity ◽  
Significant Rise ◽  
Migrating Motor Complex ◽  
Phase Iii ◽  
Complex Activity ◽  
Duodenal Motility ◽  
Motor Complex ◽  
Duodenal Acidification ◽  
Plasma Motilin

Plasma motilin concentrations were measured in dogs following duodenal acidification and alkalinization and gastric instillation of fat. Antral and duodenal motility were recorded concurrently using intraluminal manometry. Alkalinization of the duodenum produced an increase in antral and duodenal motility and a significant rise in plasma motilin. Alkaline infusions at 5 mL/min into the duodenum initiated phase III of a migrating motor complex both in the antrum and in the duodenum. Duodenal acid infusions produced no change in plasma motilin concentrations while inhibiting antral motility and stimulating duodenal motility for the duration of the infusion. Gastric instillation of 60 g fat produced a 25% increase above basal motilin levels at 50 min after instillation. Motilin levels monitored during spontaneous migrating motor complexes showed peak motilin levels occurring during maximal activity of the antral duodenal region in seven out of nine motor complexes examined but motilin peaks also occurred without migrating complexes being present in this area and, as well, complexes occurred when motilin was undetectable. These results taken together with our other studies in man confirm that a true species difference exists between man and dog in the hormonal motor response to duodenal alkalinization. Although a relationship appears to exist between the appearance of maximal migrating motor complex activity in the gastroduodenal area and plasma motilin concentrations in dogs as in humans, the motilin peaks are probably neither necessary nor sufficient to induce phase III activity.

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