scholarly journals Cannabinoids and the Immune System

2001 ◽  
Vol 6 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Thomas W Klein ◽  
Catherine A Newton ◽  
Herman Friedman
Keyword(s):  
Cannabinoid Receptors ◽  
Cell Function ◽  
Immune Cell ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Cannabinoid System ◽  
Health And Disease ◽  
And Function ◽  
Acquired Immune Deficiency

The effect of cannabimimetic agents on the function of immune cells such as T and B lymphocytes, natural killer cells and macrophages has been extensively studied over the past several decades using human and animal paradigms involving whole animal models as well as tissue culture systems. From this work, it can be concluded that these drugs have subtle yet complex effects on immune cell function and that some of the drug activity is mediated by cannabinoid receptors expressed on the various immune cell subtypes. However, the overall role of the cannabinoid system of receptors and ligands in human health and disease is still unclear and requires extensive elucidation. Further studies will define the precise structure and function of the putative immunocannabinoid system, the potential therapeutic usefulness of these drugs in chronic diseases such as acquired immune deficiency syndrome and multiple sclerosis, the effects of these agents on tumour growth and induction of apoptosis, and the potential anti-inflammatory and proinflammatory properties of cannabimimetic compounds. It is likely that the cannabinoid system, along with other neuroimmune systems, has a subtle but significant role in the regulation of immunity and that this role can eventually be exploited in the management of human disease.

scholarly journals Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands

2018 ◽  
Vol 19 (9) ◽  
pp. 2747 ◽  
Author(s):  
Imran Nizamuddin ◽  
Peter Koulen ◽  
Carole McArthur
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Exocrine Function ◽  
Lacrimal Glands ◽  
Immunodeficiency Virus ◽  
And Function ◽  
The Impact

The structure and function of exocrine glands are negatively affected by human immunodeficiency virus (HIV) infection and its co-morbidities, including innate and adaptive immune responses. At the same time, exocrine function may also be influenced by pharmacotherapies directed at the infectious agents. Here, we briefly review the role of the salivary glands and lacrimal glands in normal physiology and exocrine pathogenesis within the context of HIV infection and acquired immune deficiency syndrome (AIDS), including the contribution of antiretroviral therapies on both. Subsequently, we discuss the impact of HIV infection and the types of antiretroviral therapy on disease management and therapy development efforts.

scholarly journals Role of fibreoptic bronchoscopy in management of pneumonia in acquired immune deficiency syndrome.

BMJ ◽  
1985 ◽  
Vol 291 (6501) ◽  
pp. 1012-1013 ◽  
Author(s):  
J B Warren ◽  
R J Shaw ◽  
J N Weber ◽  
D A Holt ◽  
E E Keal ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Fibreoptic Bronchoscopy ◽  
Acquired Immune Deficiency

Operation “Denver”: The East German Ministry of State Security and the KGB's AIDS Disinformation Campaign, 1985–1986 (Part 1)

2019 ◽  
Vol 21 (4) ◽  
pp. 71-123
Author(s):  
Douglas Selvage
Keyword(s):  
Immune Deficiency Syndrome ◽  
The United States ◽  
Deficiency Syndrome ◽  
Biological Warfare ◽  
Minority Communities ◽  
State Security ◽  
East German ◽  
Online Sources ◽  
Acquired Immune Deficiency

There has been much debate in recent years about the role of the East German Ministry for State Security (Stasi) in the disinformation campaign launched in the early 1980s by the Soviet State Security Committee (KGB) regarding the origin and nature of acquired immune deficiency syndrome (AIDS). The KGB's operation, codenamed “Denver” by the Stasi (not “Infektion,” as many online sources now erroneously assert), claimed that AIDS was deliberately devised by U.S. biological warfare specialists for the U.S. government to spread in minority communities in the United States. Based on the available evidence, the Stasi's role in the AIDS disinformation campaign was limited in 1985–1986 to (1) keeping watch over Soviet-East German scientist Jakob Segal, who propagated a variant of the KGB's thesis; (2) helping to arrange for the publication and distribution of a brochure with Segal's thesis at the Non-Aligned Movement summit in Harare in 1986; and (3) facilitating Segal's interviews with certain journalists. Just as important for the ongoing formulation and spread of the KGB's AIDS disinformation was a cycle of misinformation and disinformation that arose between U.S.-based conspiracy theorists—especially Lyndon LaRouche and his followers—and authors and publications espousing Moscow's preferred theses regarding AIDS.

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