Primary Maxillofacial Large B-Cell Lymphoma in Immunocompetent Patients: Report of 5 Cases

Lymphomas of the oral cavity represent 5% of all lymphomas. They usually occur in immunocompromised patients. Lymphoma arising within a single bone, without visceral or lymph node involvement, is known as primary intraosseous lymphoma. It is a rare condition and constitutes 3.1% of malignant bone tumors and 5% of extranodal lymphomas. Primary lymphoma of the jaw is seldom seen and it is often misdiagnosed. Clinically, the manifestations are usually similar to an odontogenic tumor, cyst, or infection. Radiographically it appears as a radiolucent area that may mimic endodontic lesion, periodontal pathology, or odontogenic cyst or tumor. The initial presentation is commonly followed by multiple unnecessary extractions and/or root canal treatments. We present five cases of rare primary lymphoma of the maxillofacial complex, four of them intraosseous.

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Secondary lymph node involvement from primary cutaneous large B-cell lymphoma of the leg

Cancer ◽

10.1002/(sici)1097-0142(19990101)85:1<199::aid-cncr27>3.0.co;2-x ◽

1999 ◽

Vol 85 (1) ◽

pp. 199-207 ◽

Cited By ~ 28

Author(s):

Hans Starz ◽

Bernd-R�diger Balda ◽

Dieter Bachter ◽

Herbert B�chels ◽

Harry Vogt

Keyword(s):

Lymph Node ◽

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Lymph Node Involvement ◽

Large B Cell Lymphoma ◽

Secondary Lymph Node ◽

Node Involvement ◽

Large B Cell

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Risk factors and patterns of lymph node involvement in primary gastric large B-cell lymphoma: implications for target definition

OncoTargets and Therapy ◽

10.2147/ott.s110575 ◽

2016 ◽

Vol Volume 9 ◽

pp. 4757-4762 ◽

Cited By ~ 2

Author(s):

Xi-Mei Zhang ◽

Peiguo Wang ◽

lujun zhao ◽

zhiyong yuan ◽

ping wang

Keyword(s):

Risk Factors ◽

Lymph Node ◽

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Lymph Node Involvement ◽

Large B Cell Lymphoma ◽

Target Definition ◽

Node Involvement ◽

Large B Cell

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Prognostic impact of abdominal lymph node involvement in diffuse large B‐cell lymphoma

European Journal Of Haematology ◽

10.1111/ejh.13361 ◽

2019 ◽

Vol 104 (3) ◽

pp. 207-213

Author(s):

Maysaa Abdulla ◽

Priscilla Guglielmo ◽

Peter Hollander ◽

Gunnar Åström ◽

Håkan Ahlström ◽

...

Keyword(s):

Lymph Node ◽

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Lymph Node Involvement ◽

Prognostic Impact ◽

Abdominal Lymph Node ◽

Large B Cell Lymphoma ◽

Node Involvement ◽

Large B Cell

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Primary diffuse large B cell lymphoma of the optic chiasm in an immunocompetent patient

BMJ Case Reports ◽

10.1136/bcr-2021-243307 ◽

2021 ◽

Vol 14 (7) ◽

pp. e243307

Author(s):

Orlando De Jesus ◽

Christian Rios-Vicil ◽

Frances M Gómez-González ◽

Román Vélez

Keyword(s):

B Cell ◽

Clinical Course ◽

Cell Lymphoma ◽

Brain Mri ◽

B Cell Lymphoma ◽

Optic Chiasm ◽

Immunocompetent Patient ◽

Primary Lymphoma ◽

Large B Cell Lymphoma ◽

Large B Cell

Primary lymphoma of the visual pathway is rare, especially at the chiasm. Very few cases have been reported. The lesion is frequently confused with an optic–hypothalamic glioma. A 55-year-old man was found disoriented at his home by a friend and evaluated with a brain MRI which demonstrated an expansile mass located at the optic chiasm and hypothalamus level. The principal differential was a high-grade hypothalamic glioma due to the contrast enhancement. A biopsy of the chiasmal lesion was performed. Histological diagnosis of the lesion was compatible with a diffuse large B cell lymphoma. He was started on methotrexate and rituximab; however, his clinical course kept deteriorating, and he died 64 days after his presentation. All prior cases of primary lymphoma of the chiasm are reviewed.

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Pitfalls of Frozen Section in Gynecological Pathology: A Rare Case of Ovarian Lymphoma in an HIV-Positive Woman Resembling Dysgerminoma on Frozen Section

International Journal of Surgical Pathology ◽

10.1177/1066896918813658 ◽

2018 ◽

Vol 27 (4) ◽

pp. 387-389 ◽

Cited By ~ 1

Author(s):

Qing Wang ◽

Raul Rodriguez ◽

Jenna Z. Marcus ◽

Lisa Podolsky ◽

Damali Campbell ◽

...

Keyword(s):

B Cell ◽

Rare Case ◽

Cell Lymphoma ◽

Frozen Section ◽

B Cell Lymphoma ◽

Hiv Positive ◽

Primary Lymphoma ◽

Positive Woman ◽

Large B Cell Lymphoma ◽

Large B Cell

Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary.

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Primary Prostatic Diffuse Large B-Cell Lymphoma: a Case Report and Literature Review

Journal of Cancer & Allied Specialties ◽

10.37029/jcas.v8i1.439 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Samia Yasmeen ◽

Waqas Ahmad ◽

Omer Waqas ◽

Abdul Hameed

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

Early Stage ◽

Digital Rectal Examination ◽

B Cell Lymphoma ◽

Perineal Pain ◽

Primary Lymphoma ◽

Abnormal Finding ◽

Large B Cell Lymphoma ◽

Large B Cell

Introduction: Primary lymphomas of the prostate are globally rare representing less than 0.1% of all prostatic neoplasms. In this paper we present a case of an early stage diffuse large B-cell lymphoma (DLBCL) of the prostate managed with six cycles of rituximab-based chemotherapy, and review the related literature. Case description: A 32-year-old man presented to our clinic with complaints of difficult urination and perineal pain. An enlarged, hard and nodular prostate was palpable on digital rectal examination. Needle biopsy of the prostate was performed, which revealed diffuse large B-cell non-Hodgkin's lymphoma by immunohistochemical studies. CT scan showed large pelvic mass arising from prostate encasing ureters with bilateral hydronephroureter. No abnormal finding was seen on abdominal CT and bone marrow histology. Therefore, the disease was classified into the clinical stage IAXE according to Ann Arbor's criteria. The patient achieved complete response (CR) to six cycles of rituximab based combination chemotherapy, R-CHOP with CNS prophylaxis. He remained disease free, until now, 36 months after the end of chemotherapy. Practical Implications: According to the literature, the treatment and prognosis of primary lymphoma of the prostate is the same as that of other nodal lymphomas. Rituximab-based regimen should be considered in the management of prostatic diffuse large B-cell lymphoma.

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Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone

Case Reports in Pathology ◽

10.1155/2018/4160925 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7

Author(s):

Shachar Kenan ◽

Leonard Kahn ◽

Morris Edelman ◽

Arlene Redner ◽

Samuel Kenan

Keyword(s):

Cell Lymphoma ◽

B Cell Lymphoma ◽

Left Knee ◽

Primary Lymphoma ◽

Large B Cell Lymphoma ◽

Appropriate Treatment ◽

Clinical Consequences ◽

Pediatric Patient Population ◽

Radiolucent Lesion ◽

Motion Imaging

Primary lymphoma of bone (PLB) confined to the epiphysis has only been described in four other patients. Due to the rarity of this entity, diagnosis has often been delayed, leading to mismanagement with adverse clinical consequences. We report a fifth case of primary epiphyseal lymphoma of bone located in the left distal medial femoral epiphysis of a 13-year-old boy. Radiographic and histologic features of PLB are discussed, along with a review of the literature and pitfalls of misdiagnosis. The patient initially presented with six months of progressive left knee pain with an associated loss of passive range of motion. Imaging revealed a mixed radiolucent lesion within the left distal medial femoral epiphysis with cortical breakthrough. A core biopsy was performed revealing a blue round cell tumor. Thanks to modern immunohistochemistry techniques, a diagnosis of primary lymphoma of bone was quickly made. The patient thus avoided further surgical intervention and received the appropriate treatment of chemotherapy, with subsequent rapid resolution of the lesion. This case highlights the necessity of including primary lymphoma of bone in all epiphyseal lesion differential diagnoses, especially in the pediatric patient population when aggressive radiographic features are present.

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Diffuse Large B-Cell Lymphoma of the Cervix Diagnosed on Cervical Screening Cytology

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz118.013 ◽

2019 ◽

Vol 152 (Supplement_1) ◽

pp. S97-S97

Author(s):

Todd Needs ◽

Peter Bonneau ◽

Gabriella Cardoza-Favarato

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

Cervical Screening ◽

B Cell Lymphoma ◽

Inflammatory Cells ◽

Cervical Cytology ◽

Primary Lymphoma ◽

Cell Block ◽

Large B Cell Lymphoma ◽

Large B Cell

Abstract Case Presentation Primary lymphoma of the cervix is an uncommon entity and far more rarely diagnosed on routine screening cervical cytology. We present a case of a 38-year-old female with a 1-year history of heavy cyclical menstrual bleeding and interval spotting. She had no other significant past medical or obstetric history. On cervical exam, obscuring blood was noted without distinct abnormalities of the visualized cervix. Pathologic Findings Cervical cytology by ThinPrep (Hologic, Marlborough, MA) liquid-based cytology preparation demonstrated atypical squamous cells of undetermined significance as well as an abundant population of atypical lymphoid-appearing cells. Morphology of this second population was characterized by large cells (2-3 times the size of background inflammatory cells) with high nuclear-to-cytoplasm ratio, vesicular chromatin, occasional nucleoli, marked nuclear membrane irregularities, and scant cytoplasm. A cell block of the specimen was performed and demonstrated a mature but cytologically large and atypical lymphoid population. Immunohistochemistry on the cell block specimen was consistent with a B-cell immunophenotype with strong CD45 and CD20 immunolabeling. Subsequent radiologic workup showed a diffusely enlarged cervix with increased metabolic uptake, as well as bilateral metabolically active pelvic lymph nodes. Conclusion Cervical and endometrial curettings obtained at an outside facility confirmed the diagnosis of lymphoma that was further categorized as diffuse large B-cell lymphoma, germinal center B-cell type. This case highlights an uncommon diagnosis found on screening cervical cytology. It reinforces awareness of the potential for lymphoid neoplasms on cervical cytology and the differential diagnosis associated with such cases.

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