scholarly journals Inflammatory Pseudotumor of the Head Presenting with Hemiparesis and Aphasia

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
K. Saifudheen ◽  
James Jose ◽  
V. Abdul Gafoor
Keyword(s):  
Inflammatory Pseudotumor ◽  
Brain Parenchyma ◽  
Intracranial Extension ◽  
Left Temporal Lobe ◽  
Orbital Pseudotumor ◽  
Superior Orbital Fissure ◽  
Benign Condition ◽  
Wernicke's Aphasia ◽  
Orbital Muscle ◽  
Insight Into

Inflammatory pseudotumor most commonly occurs in the orbit and produces orbital pseudotumor, but extension into brain parenchyma is uncommon. We report a case of inflammatory pseudotumor involving sphenoid sinus, cavernous sinus, superior orbital fissure, orbital muscle, and intracranial extension into left temporal lobe producing right hemiparesis and wernicke's aphasia. The patient improved clinically and radiologically with steroid administration. This paper provides an insight into the spectrum of involvement of inflammatory pseudotumor and the importance of early diagnosis of the benign condition.

IgG4-related inflammatory pseudotumor of the brain parenchyma: a case report and literature review

2018 ◽  
Vol 118 (4) ◽  
pp. 617-627 ◽  
Author(s):  
Zhuqing Zhang ◽  
Weiwei Fu ◽  
Minghui Wang ◽  
Lei Niu ◽  
Bin Liu ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Inflammatory Pseudotumor ◽  
Brain Parenchyma ◽  
The Brain

scholarly journals Inflammatory Pseudotumor in the Nasal Cavity and Sinuses: A Case Report and Associated Literature Review

2020 ◽  
pp. 014556132092448
Author(s):  
Jing Li ◽  
Maohua Wang ◽  
Wangwei Li ◽  
Yuejin Tao ◽  
Xinyi Shi
Keyword(s):  
Nasal Cavity ◽  
Nasal Obstruction ◽  
Inflammatory Pseudotumor ◽  
Plasma Cells ◽  
Clinical Manifestations ◽  
Good Prognosis ◽  
Benign Condition ◽  
Ocular Symptoms ◽  
Facial Swelling ◽  
The Right

Inflammatory pseudotumor (IP) is a clinically aggressive but histologically benign condition of unknown cause. It rarely appears in the nasal cavity and sinuses. Here, we describe a 24-year-old female with the main symptom of right nasal obstruction. Examinations showed dilation in the right maxillary sinus and a pale neoplasm in the nasal cavity. The neoplasm was completely excised under endoscope. Postoperative pathology showed significant proliferation of plasma cells and lymphocytes, indicating the presence of IP. No recurrence was found during 20 months of follow-up. Only 28 cases (10 males and 18 females, average 41.04 years) have been reported on Pubmed. The main clinical manifestations were nasal obstruction, epistaxis, facial swelling and pain, eyeball protrusion, diplopia, and other ocular symptoms. Inflammatory pseudotumor always erodes the surrounding bone and requires active treatments. Surgery is the optimal option with a good prognosis.

Computerized Axial Tomography in Inflammatory Pseudotumor of the Orbit

1980 ◽  
Vol 88 (4) ◽  
pp. 378-383 ◽  
Author(s):  
Lee D. Rowe ◽  
William Tsiaras ◽  
Charles Nichols ◽  
Allen R. Myers
Keyword(s):  
Wegener’S Granulomatosis ◽  
Inflammatory Pseudotumor ◽  
Wegener's Granulomatosis ◽  
Clinical Findings ◽  
High Dose ◽  
Orbital Pseudotumor ◽  
Intravenous Contrast ◽  
Axial Tomography ◽  
Noninvasive Technique ◽  
Select Group

Although thyrotoxicosis and orbital complications of acute ethmoid or frontal sinusitis are among the most common causes of unilateral exophthalmos, inflammatory pseudotumor is frequently accompanied by progressive acute unilateral proptosis. Because the associated chemosis, scleral erythema, and ophthalmoplegia constitute a spectrum of clinical findings present in numerous inflammatory orbital disorders and systemic diseases, the diagnosis of inflammatory pseudotumor is one of exclusion, often requiring orbital biopsy. Four patients without evidence of sinusitis, endocrinopathy, collagen vascular disease, or Wegener's granulomatosis are described. The diagnosis of orbital pseudotumor was disclosed by computed axial tomography, thus avoiding orbitotomy. The finding of scleral and choroidal thickening with enhancement following intravenous contrast injection represents a select group of patients with orbital pseudotumor and differentiates them from patients with endocrine exophthalmopathy or neoplasms. This noninvasive technique is extremely valuable because early diagnosis is critical for successful treatment. All four patients responded dramatically to high-dose corticosteroid therapy. In the absence of significant clinical response, however, Wegener's granulomatosis, lymphoma, and rhabdomyosarcoma, especially in younger patients, must be carefully excluded. Orbital exploration or decompression or both are used when proptosis, headache, or orbital pain does not resolve promptly, visual acuity deteriorates, or the diagnosis remains unknown.

Intracranial Extension and Bone Destruction in Orbital Pseudotumor

1986 ◽  
Vol 104 (3) ◽  
pp. 380-384 ◽  
Author(s):  
L. P. Frohman ◽  
M. J. Kupersmith ◽  
J. Lang ◽  
D. Reede ◽  
R. T. Bergeron ◽  
...  
Keyword(s):  
Bone Destruction ◽  
Intracranial Extension ◽  
Orbital Pseudotumor

Juvenile nasopharyngeal angiofibroma with intracranial extension – diagnosis and treatment.

2019 ◽  
Vol 73 (6) ◽  
Author(s):  
Wiesław Gołąbek ◽  
Anna Szymańska ◽  
Marcin Szymański ◽  
Elżbieta Czekajska-Chehab ◽  
Tomasz Jargiełło
Keyword(s):  
Infratemporal Fossa ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Intracranial Extension ◽  
Radiological Findings ◽  
Superior Orbital Fissure ◽  
Nasopharyngeal Angiofibroma ◽  
Therapeutic Modalities ◽  
Stage Ivb ◽  
Extensive Involvement

Introduction This retrospective study analyzes radiological findings, therapeutic management and outcomes of patients with intracranial extension of juvenile nasopharyngeal angiofibroma (JNA). The routes of intracranial spread, incidence of intracranial disease and influence on therapeutic approach are discussed. Material and methods An evaluation on the records of 62 patients with JNA was performed and 10 patients with intracranial tumors were included in the study. All patients were males aged 10 to 19 years. Results According to Andrews' classification 8 patients presented with stage IIIb, 1 patient stage IVa and another patient stage IVb tumor. Intracranial invasion was extradural in 8 cases and intradural in 2 patient. Surgery was performed in 9 cases and the most common was combined approach: infratemporal fossa and sublabial transantral. One patient was referred for radiotherapy. Follow-up ranged from 8 to 26 years. There was extracranial recurrence in 2 (22%) of 9 operated patients. Conclusions The superior orbital fissure is the most frequent route of intracranial spread in patients with extensive involvement of the infratemporal fossa. Due to high risk of recurrence and potential serious complications advanced cases of JNA should be managed by experienced multidisciplinary team, preferably in tertiary referral centers, with an access to modern diagnostic and therapeutic modalities.

scholarly journals Control of microglial dynamics by Arp2/3 and the autism and schizophrenia-associated protein Cyfip1

2020 ◽  
Author(s):  
James Drew ◽  
I. Lorena Arancibia-Carcamo ◽  
Renaud Jolivet ◽  
Guillermo Lopez-Domenech ◽  
David Attwell ◽  
...  
Keyword(s):  
Dynamic Network ◽  
Brain Parenchyma ◽  
Core Component ◽  
Neuropsychiatric Disease ◽  
Morphological Complexity ◽  
Conditional Deletion ◽  
Mechanistic Insight ◽  
Regulatory Complex ◽  
Sense And Respond ◽  
Insight Into

AbstractMicroglia use a highly complex and dynamic network of processes to sense and respond to their surroundings. Microglial dynamics differ throughout development and in neurological and neuropsychiatric disease, though mechanistic insight into these changes is lacking. Here we identify novel roles for regulators of the actin cytoskeleton in controlling microglial behaviour. We show that the actin branching complex Arp2/3 is critical for maintaining microglial morphology and required for surveillance but not chemotactic motility. Neuropsychiatric disease-associated Cyfip1, a core component of the WAVE regulatory complex that links Rac1 signalling to Arp2/3 activation, is highly expressed in microglia but has unknown function. We report that conditional deletion of Cyfip1 in mouse microglia reduces morphological complexity and surveillance of brain parenchyma, and increases activation state as defined by CD68 expression. Thus, altered actin-dependent microglial dynamics mediated by Cyfip1 and Arp2/3 may contribute to neuropsychiatric disease.

scholarly journals Inflammatory Pseudotumor of the Brain Parenchyma with IgG4 Hypergammaglobulinemia

2016 ◽  
Vol 55 (14) ◽  
pp. 1911-1916 ◽  
Author(s):  
Haruko Tanji ◽  
Hiroaki Okada ◽  
Ryosuke Igari ◽  
Yoshitaka Yamaguchi ◽  
Hiroyasu Sato ◽  
...  
Keyword(s):  
Inflammatory Pseudotumor ◽  
Brain Parenchyma ◽  
The Brain

scholarly journals Inflammatory Pseudotumor of the Kidney

2011 ◽  
Vol 1 ◽  
pp. 7 ◽  
Author(s):  
Mehmet Ruhi Onur ◽  
Fatih Firdolas ◽  
Ercan Kocakoç ◽  
Irfan Orhan
Keyword(s):  
Inflammatory Pseudotumor ◽  
Psoas Muscle ◽  
Inflammatory Cells ◽  
Flank Pain ◽  
Unknown Etiology ◽  
Fibroblast Cells ◽  
Resonance Imaging ◽  
Benign Condition ◽  
Posterior Extension ◽  
Operative Findings

Inflammatory pseudotumor of the kidney is a rare benign condition with unknown etiology that can mimic malignancy. We report a case of inflammatory pseudotumor of the kidney. A 59-year-old male patient was admitted with a complaint of right flank pain and hematuria. Ultrasonography and magnetic resonance imaging of the patient revealed a 9 cm × 10 cm mass originating from the renal parenchyma with posterior extension. Operative findings revealed a mass adhering to the psoas muscle. Histopathologic examination demonstrated spindle-shaped fibroblast cells accompanying inflammatory cells. The pathological diagnosis was renal inflammatory pseudotumor. Repeated US and computed tomography revealed complete remission.

scholarly journals Myeloid Sarcoma: A Rare Case of an Orbital Mass Mimicking Orbital Pseudotumor Requiring Neurosurgical Intervention

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Christopher Payne ◽  
William C. Olivero ◽  
Bonnie Wang ◽  
Seong-Jin Moon ◽  
Arash Farahvar ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Rare Case ◽  
Granulocytic Sarcoma ◽  
Myeloid Sarcoma ◽  
Initial Presentation ◽  
Illustrative Case ◽  
Orbital Pseudotumor ◽  
Superior Orbital Fissure ◽  
Orbital Mass ◽  
Neurosurgical Intervention

Objective. A rare case of myeloid sarcoma (MS), previously referred to as granulocytic sarcoma or chloroma, is presented. Representing a unique form of acute myeloid leukemia (AML), MS may rarely occur in adults. Even rarer, MS may occur as the initial presentation of AML.Methods. We report a singular and illustrative case of an orbital pseudotumor mimicking mass in a 65-year-old male as the initial presentation of AML.Results. Neurosurgical intervention was required to establish the definitive diagnosis via right modified orbitofrontozygomatic craniotomy as well as to decompress the optic canal, superior orbital fissure, and orbit.Conclusion. Postoperatively, he reported decreased pain and improvement of his vision. Further examination revealed decreased proptosis and improved extraocular mobility. Pathological findings demonstrated MS. We review the literature and discuss the neurosurgical relevance of MS as the initial presentation of AML.

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