scholarly journals Treatment of Fatigue in Multiple Sclerosis Patients: A Neurocognitive Approach

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Mauro Catalan ◽  
Alessandra De Michiel ◽  
Alessio Bratina ◽  
Susanna Mezzarobba ◽  
Lorella Pellegrini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Motor Planning ◽  
Rehabilitation Program ◽  
Severity Scale ◽  
Impact Scale ◽  
Disability Status ◽  
Neurocognitive Rehabilitation ◽  
Fatigue Severity ◽  
Fatigue Impact Scale ◽  
Multiple Sclerosis Patients

The objective of the study was to treat fatigue in patients with multiple sclerosis (MS) by a neurocognitive rehabilitation program aimed at improving motor planning by using motor imagery (MI). Twenty patients with clinically definite MS complaining of fatigue were treated for five weeks with exercises of neurocognitive rehabilitation twice a week. Patients were evaluated by Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS), MSQoL54, Expanded Disability Status Scale (EDSS), and MS Functional Composite (MSFC). After treatment, a decrease in fatigue was detected with both FSS () and MFIS (). MSFC () and MSQoL54 () scores improved compared to baseline. At six-month followup, the improvement was confirmed for fatigue (FSS, ; MFIS ) and for the physical subscale of MSQoL54 (). No differences in disability scales were found. These results show that neurocognitive rehabilitation, based on MI, could be a strategy to treat fatigue in MS patients.

Validation of the Russian version of the Fatigue Impact Scale and Fatigue Severity Scale in multiple sclerosis patients

2018 ◽  
Vol 138 (5) ◽  
pp. 408-416 ◽  
Author(s):  
Yury V. Gavrilov ◽  
Galina G. Shkilnyuk ◽  
Philipp O. Valko ◽  
Igor D. Stolyarov ◽  
Elena V. Ivashkova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Fatigue Severity Scale ◽  
Severity Scale ◽  
Russian Version ◽  
Impact Scale ◽  
Fatigue Severity ◽  
Fatigue Impact Scale ◽  
Multiple Sclerosis Patients

A longitudinal study on effects of a six-week course for energy conservation for multiple sclerosis patients

2008 ◽  
Vol 14 (4) ◽  
pp. 500-505 ◽  
Author(s):  
C. Sauter ◽  
K. Zebenholzer ◽  
J. Hisakawa ◽  
J. Zeitlhofer ◽  
K. Vass
Keyword(s):  
Multiple Sclerosis ◽  
Sleep Quality ◽  
Energy Conservation ◽  
Fatigue Severity Scale ◽  
Severity Scale ◽  
Fatigue Management ◽  
Impact Scale ◽  
Fatigue Severity ◽  
Fatigue Impact Scale

Objective Fatigue management and energy conservation are effective strategies to minimize fatigue in multiple sclerosis (MS). Sustained results have not yet been reported. Methods A fatigue management course was provided for 32 MS patients. They were tested prior to, directly after participation in the course and in a 7—9 month follow-up with the Fatigue Severity Scale, the MS-specific Fatigue Scale, the Modified Fatigue Impact Scale (MFIS), the Pittsburgh Sleep Quality Index and a self-rating scale for depression. The Expanded Disability Status Score (EDSS) and the MS functional composite (MSFC) were evaluated before and after participation in the course. Results The total score and the Cognitive and Physical subscores of the MFIS showed significant improvements on both points of time. Scores in the Fatigue Severity Scale, MS-specific Fatigue Scale and Psychosocial Fatigue Impact Scale did not improve significantly. MS functional composite and EDSS remained unchanged after six weeks of course participation. Subjective sleep quality improved directly after participation in the course and after 7—9 months. The depression score decreased significantly to a normal level at the end of training and in the 7—9 month follow-up. Conclusion Fatigue management enables MS patients to cope with their fatigue and energy more effectively. Follow-up evaluations showed stable results after 7—9 months. Multiple Sclerosis 2008; 14: 500—505. http://msj.sagepub.com

scholarly journals Changes in Fatigue and Cognition in Patients with Relapsing Forms of Multiple Sclerosis Treated with Natalizumab

2013 ◽  
Vol 15 (3) ◽  
pp. 120-128 ◽  
Author(s):  
Jeffrey Wilken ◽  
Robert L. Kane ◽  
Cynthia L. Sullivan ◽  
Mark Gudesblatt ◽  
Sylvia Lucas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Baseline Score ◽  
Open Label ◽  
Impact Scale ◽  
Disability Status ◽  
Automated Neuropsychological Assessment Metrics ◽  
Fatigue Severity ◽  
Fatigue Impact Scale ◽  
Median Change

Fatigue and cognitive impairment are debilitating features of multiple sclerosis (MS). ENER-G was a 12-month, open-label, multicenter, single-arm observational study designed to evaluate changes in fatigue and cognition in MS patients treated with natalizumab. Adults with relapsing MS and initiating natalizumab were enrolled. The primary endpoint was change in Visual Analog Scale for Fatigue (VAS-F) score over 12 weeks. Changes in Modified Fatigue Impact Scale (MFIS) score, Fatigue Severity Scale (FSS) score, and cognitive performance, using Automated Neuropsychological Assessment Metrics (ANAM), were also assessed. Patients (N = 89) had a mean age of 41 years and a median Expanded Disability Status Scale score of 3.0, and 83% had used at least two prior MS therapies. Significant improvements were observed and maintained at 12 weeks in VAS-F (mean ± SD baseline score, 77.7 ± 10.2; mean ± SD change, −14.9 ± 17.1; P < .0001), MFIS (mean baseline score, 59.1 ± 12.2; mean change, −7.4 ± 11.8; P < .0001), and FSS (median baseline score, 6.3 [range, 3.9–7.0]; median change, −0.4 [range, −2.9–1.4]; P < .0001). Cognitive performance remained stable or improved (depending on the ANAM measure). Thus significant improvements in fatigue were maintained over time, and cognitive performance improved or remained stable up to 48 weeks after initiation of natalizumab in MS patients with some degree of fatigue.

Correlation of self-assessed fatigue and alertness in multiple sclerosis

2010 ◽  
Vol 16 (9) ◽  
pp. 1134-1140 ◽  
Author(s):  
Nicholetta Weinges-Evers ◽  
Alexander U Brandt ◽  
Markus Bock ◽  
Caspar F Pfueller ◽  
Jan Dörr ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neuropsychological Tests ◽  
Fatigue Severity Scale ◽  
Expanded Disability Status Scale ◽  
Severity Scale ◽  
Disability Status ◽  
Attentional Performance ◽  
Fatigue Severity ◽  
Repeatable Battery ◽  
Multiple Sclerosis Patients

Background: Fatigue is the most common symptom in multiple sclerosis patients, but is difficult to measure; quantification thus relies on self-assessed questionnaires. Objective: To evaluate a battery of neuropsychological tests regarding their capacity to objectify self-reported fatigue. Methods: We assessed the correlation between age, gender, education, Kurtzke’s Expanded Disability Status Scale, depression, fatigue and neuropsychological testing using a cross-sectional approach in 110 multiple sclerosis patients. Fatigue was measured with the Fatigue Severity Scale. Cognition was measured using a series of neuropsychological tests including three subtests of the Test of Attentional Performance, the Brief Repeatable Battery of Neuropsychological Tests and the Faces Symbol Test. Results: According to the Fatigue Severity Scale 51.4% of the cohort were fatigued (scores ≥4). Age, education and depression showed a significant correlation with the Fatigue Severity Scale. Only 5.5% of the cohort exhibited cognitive impairment in the Brief Repeatable Battery of Neuropsychological Tests scores. After correction for age, education, Expanded Disability Status Scale and depression, Fatigue Severity Scale scores were an independent predictor of performance in the alertness subtest of the Test of Attentional Performance (standardized coefficient beta = 0.298, p = 0.014). Conclusion: The alertness subtest of the Test of Attentional Performance may offer an objective method of evaluating self-reported fatigue, and may therefore — in addition to the Fatigue Severity Scale — be a suitable tool for the assessment of multiple sclerosis patients complaining of fatigue.

scholarly journals Poor Sleep in Multiple Sclerosis Correlates with Beck Depression Inventory Values, but Not with Polysomnographic Data

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Christian Veauthier ◽  
Gunnar Gaede ◽  
Helena Radbruch ◽  
Klaus-Dieter Wernecke ◽  
Friedemann Paul
Keyword(s):  
Multiple Sclerosis ◽  
Beck Depression Inventory ◽  
Pittsburgh Sleep Quality Index ◽  
Poor Sleep ◽  
Severity Scale ◽  
Analog Scale ◽  
Impact Scale ◽  
Fatigue Severity ◽  
Fatigue Impact Scale ◽  
The Relationship

Objectives. Pittsburgh Sleep Quality Index (PSQI) values correlate with depression, but studies investigating the relationship between PSQI values and polysomnographic (PSG) data showed inconsistent findings.Methods. Sixty-five consecutive patients with multiple sclerosis (MS) were retrospectively classified as “good sleepers” (GS) (PSQI ≤ 5) and “poor sleepers” (PS) (PSQI > 5). The PSG data and the values of the Visual Analog Scale (VAS) of fatigue, Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and the Beck Depression Inventory (BDI) were compared.Results. No significant differences were found either for PSG data or for ESS, MFIS, and FSS values; but PS showed significantly increased BDI and VAS values.Conclusions. Poor sleep is associated with increased depression and fatigue scale values.

Psychometric properties of the Fatigue Severity Scale and the Modified Fatigue Impact Scale

2013 ◽  
Vol 331 (1-2) ◽  
pp. 102-107 ◽  
Author(s):  
Y.C. Learmonth ◽  
D. Dlugonski ◽  
L.A. Pilutti ◽  
B.M. Sandroff ◽  
R. Klaren ◽  
...  
Keyword(s):  
Psychometric Properties ◽  
Fatigue Severity Scale ◽  
Severity Scale ◽  
Impact Scale ◽  
Fatigue Severity ◽  
Fatigue Impact Scale

Validity and reliability of the Greek version of the Modified Fatigue Impact Scale in multiple sclerosis patients

2014 ◽  
Vol 37 (3) ◽  
pp. 271-276 ◽  
Author(s):  
Daphne Bakalidou ◽  
Konstantinos Voumvourakis ◽  
Zoi Tsourti ◽  
Effie Papageorgiou ◽  
Antonios Poulios ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Validity And Reliability ◽  
Greek Version ◽  
Impact Scale ◽  
Fatigue Impact Scale ◽  
Multiple Sclerosis Patients

scholarly journals Restless Leg Syndrome in Patients with Multiple Sclerosis and its Effect on Frequency of Daytime Sleepiness and Fatigue of the Patients

2016 ◽  
Vol 5 (1) ◽  
pp. 7-12
Author(s):  
Nahid Ashjazadeh ◽  
Zahra Shamszadeh
Keyword(s):  
Multiple Sclerosis ◽  
Daytime Sleepiness ◽  
Study Group ◽  
Expanded Disability Status Scale ◽  
Restless Leg Syndrome ◽  
Severity Scale ◽  
Medical Sciences ◽  
Disability Status ◽  
Fatigue Severity ◽  
Study Participants

Background: Restless leg syndrome (RLS), fatigue and daytime sleepiness are three known co-morbidities in patients with multiple sclerosis (MS). The aim of this study was to evaluate the frequency of RLS in patients with MS and its effect on the frequency of fatigue and daytime sleepiness in these patients. Material and Methods: One hundred twenty patients who referred to the Inpatients Neurology Ward of Chamran hospital, affiliated with the Shiraz University of Medical Sciences, from June 2014 to March 2015, were selected as the study participants. The patients with clinically definite MS, according to the 2010 Revised Mc-Donald criteria, and expanded disability status scale (EDSS) ≤5.5 were included. RLS, fatigue and daytime sleepiness were assessed by the criteria of the International RLS study group (IRLSSG), fatigue severity scale (FSS) and Epworth sleepiness scale (ESS) respectively and the related statistical analyzes were conducted. Results: Seventy eight patients (65%) met all the four IRLSSG criteria, 77 patients (64.1%) suffered from fatigue and only 36 patients (30%) had excessive daytime sleepiness. RLS was not significantly linked to mean age, sex, MS duration, and daytime sleepiness of the studied MS patients, but fatigue was more frequent in MS patients with RLS, which was statistically significant (P=0.018). Conclusion: The main result of this study is that RLS is a common comorbidity in MS and the patients with MS, who also suffer from RLS. They have frequently experienced higher fatigue symptoms than those without RLS. Therefore, the appropriate diagnosis and management of RLS may improve both RLS and fatigue in these patients. [GMJ. 2016;5(1):7-12]

The Effect of an Educational Program on Fatigue Level Among Multiple Sclerosis Patients

2021 ◽  
Vol 15 (6) ◽  
pp. 1695-1699
Author(s):  
Dalia Ibrahem Mustafa Abdel-Azem ◽  
Nawal Abdel Monem Fouad ◽  
Afaf Ibrahim
Keyword(s):  
Multiple Sclerosis ◽  
Educational Program ◽  
University Hospital ◽  
Daily Routine ◽  
Dietary Knowledge ◽  
Knowledge Questionnaire ◽  
Impact Scale ◽  
Quasi Experimental ◽  
Fatigue Impact Scale ◽  
Multiple Sclerosis Patients

Background: Multiple sclerosis is a chronic disease that affect all aspects of the patients’ life causing multiple progressive symptoms; most common fatigue which leads to dependency of patients on their family for carrying out their daily routine activities. Aim: The present study aims at evaluating the effect of an educational program on fatigue level among multiple sclerosis patients. Design: A quasi-experimental one-group pretest-posttest was used. Setting: the study was conducted in multiple sclerosis outpatient clinic in El-Kasr El-Eini University Hospital. Sample: A convenient sample of (250) multiple sclerosis patients. Tools: Two tools were used: first tool was Structured MS patient dietary knowledge questionnaire, second tool was The Arabic Version of Modified Fatigue Impact Scale. Results: Showed a highly statistical negative correlation between dietary knowledge and cognitive, psychosocial fatigue among MS patients in pre, post and 3 months after implementation of the program. Conclusions: The results of this study indicated that MS patients' dietary knowledge improved after application of the educational program as well as there was a decline in MS patients' fatigue level with statically significance differences between pre, post and 3 months after application of the program. Recommendation: Dissemination of dietary knowledge program among other multiple sclerosis patients. Keywords: Multiple sclerosis patients, dietary knowledge, fatigue

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