scholarly journals Assessing Errors Inherent in OCT-Derived Macular Thickness Maps

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Daniel Odell ◽  
Adam M. Dubis ◽  
Jackson F. Lever ◽  
Kimberly E. Stepien ◽  
Joseph Carroll
Keyword(s):  
Axial Length ◽  
Retinal Thickness ◽  
Normal Subjects ◽  
Macular Thickness ◽  
Ideal Observer ◽  
Factors Affecting ◽  
Data Collection And Analysis ◽  
Thickness Measurements ◽  
Retinal Pathologies ◽  
Sd Oct

SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot was not positioned at the center of the fovea (which can occur as a result of errant fixation). Cumulative error can exceed hundreds of microns, even under “ideal observer” conditions. This preventable error is particularly relevant when attempting to compare macular thickness maps to normative databases or measuring the area or volume of retinal features.

scholarly journals Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0222850 ◽  
Author(s):  
Nora Denk ◽  
Peter Maloca ◽  
Guido Steiner ◽  
Christian Freichel ◽  
Simon Bassett ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Cynomolgus Monkeys ◽  
Thickness Measurements ◽  
Sd Oct

Accuracy of the ISNT rule and its variants for differentiating glaucomatous from normal eyes in a population-based study

2020 ◽  
Vol 104 (10) ◽  
pp. 1412-1417 ◽  
Author(s):  
Edouard Maupin ◽  
Florian Baudin ◽  
Louis Arnould ◽  
Allasane Seydou ◽  
Christine Binquet ◽  
...  
Keyword(s):  
Optic Disc ◽  
Normal Subjects ◽  
Population Based ◽  
Retinal Nerve Fibre Layer ◽  
Population Based Study ◽  
Neuroretinal Rim ◽  
Rnfl Thickness ◽  
Thickness Measurements ◽  
Isnt Rule ◽  
Sd Oct

AimsTo evaluate the accuracy of the ISNT rule (I=inferior, S=superior, N=nasal, T=temporal) and its variants with neuroretinal rim width and retinal nerve fibre layer (RNFL) thickness measurements differentiating normal from glaucomatous eyes.MethodsThe diagnosis accuracy of the ISNT rule and its variants was evaluated in a population-based study. Neuroretinal rim widths were measured on monoscopic optic disc photographs with an image-processing program. RNFL thickness measurements were obtained with spectral-domain optical coherence tomography (SD-OCT).ResultsIn this study including 940 normal subjects and 93 patients with glaucoma, the sensitivity of the ISNT rule with optic disc photographs was 94.1% (95% CI 90.2 to 98.1), whereas its specificity was 49.2% (46.9 to 51.6). When using the IST rule, the sensitivity decreased to 69.9% (62.1 to 77.6) with a higher specificity, 87.0% (85.3 to 88.6). All the diagnosis indicators were somewhat lower for the different rules using RNFL thickness: the sensitivity of the ISNT rule was 79.4% (72.6 to 86.2) and its specificity was 34.1% (31.9 to 36.4). With the IST rule, the sensitivity decreased to 50.0% (41.6 to 58.4) while the specificity increased to 64.9% (62.7 to 67.2).ConclusionsThe ISNT and IST rules applied to neuroretinal rim width measurement by optic disc photographs are useful and simple tools for differentiating normal from glaucomatous eyes. The translation of these rules to RNFL thickness by SD-OCT is of limited value.

Reproducibility of Macular Thickness Measurements Using Cirrus SD-OCT in Neovascular Age-Related Macular Degeneration

2010 ◽  
Vol 51 (9) ◽  
pp. 4788 ◽  
Author(s):  
Mariacristina Parravano ◽  
Francesco Oddone ◽  
Barbara Boccassini ◽  
Francesca Menchini ◽  
Adele Chiaravalloti ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Macular Thickness ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Thickness Measurements ◽  
Sd Oct

Comparing Retinal Thickness Measurements Using Automated Fast Macular Thickness Map versus Six-Radial Line Scans with Manual Measurements

Ophthalmology ◽  
2009 ◽  
Vol 116 (5) ◽  
pp. 964-970 ◽  
Author(s):  
Mehran Taban ◽  
Sumit Sharma ◽  
Dawn R. Williams ◽  
Nadia Waheed ◽  
Peter K. Kaiser
Keyword(s):  
Retinal Thickness ◽  
Macular Thickness ◽  
Radial Line ◽  
Thickness Measurements

scholarly journals Optical Coherence Tomography Analysis of Macular Thickness in Children with Amblyopia

2020 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Retinal Thickness ◽  
Imaging Techniques ◽  
Macular Thickness ◽  
Response To Treatment ◽  
Optic Coherence Tomography ◽  
Significant Difference ◽  
Retinal Structure ◽  
Thickness Measurements ◽  
Abnormal Visual ◽  
Fellow Eyes

Purpose: To compare central, inner and outer ring macular thickness measured with optic coherence tomography (OCT) in children with unilateral amblyopia. To analyze the differences in retinal structure among strabismic, anisometropic and combined (strabismus + anisometropia) amblyopia. Background: Amblyopia is a reduction of visual acuity in one or both eyes due to an abnormal visual input during the development of the visual system. It is mainly caused by strabismus, anisometropia or high bilateral refractive errors, and visual deprivation. Although it has been always said that the amblyopic eye is an otherwise healthy eye, the imaging techniques developed lately, especially OCT and angio OCT, may show differences in retinal structures that could have a role in the development of amblyopia and/or its response to treatment. Methods: Retrospective review of amblyopic children followed up in our hospital. 60 children with unilateral amblyopia due to anisometropia and/or strabismus, with a good quality OCT exam, were included. We analyzed 9 thickness measurements: central macular thickness (1mm ring) and 4 sectors in inner (3mm) and outer (6mm) rings. Results: Data from 60 children is included. Mean retinal thickness at the central 1mm ring was 249.15µm for amblyopic eyes vs 238.3µm for fellow eye (p=0.000). For the thickness in the other 8 sectors for inner and outer rings no statistically significant differences were found. The central retina measurement was thicker in the anisometropic amblyopia group (p=0.003), but no statistically significant difference was found in the strabismic (p=0.066) and combined group (p=0.055). Conclusions: Central retinal thickness was significantly greater in amblyopic eyes compared to fellow eyes. This difference in thickness is also statistically significant in patients with anisometropia but not in those with strabismus or strabismus + anisometropia. Further studies with more patients are recommended.

scholarly journals Association of macular thickness with parapapillary atrophy in myopic eyes

2020 ◽  
Author(s):  
Helong Piao ◽  
Yue Guo ◽  
Jun Young Ha ◽  
Mi Sun Sung ◽  
Sang Woo Park
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Axial Length ◽  
Choroidal Thickness ◽  
Automatic Segmentation ◽  
Linear Regression Analysis ◽  
Peripheral Region ◽  
Macular Thickness ◽  
Parapapillary Atrophy ◽  
Sd Oct

Abstract Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes.Methods: The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch’s membrane (PPA+BM and PPA-BM, respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA.Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA-BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA+BM width and macular intraretinal layer thickness. Moreover, both PPA+BM and PPA-BM widths significantly correlated with subfoveal choroidal thickness.Conclusions: Macular intraretinal layer thickness may be affected by PPA-BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

scholarly journals Interocular Symmetry in Macular Choroidal Thickness in Children

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Christiane Al-Haddad ◽  
Lama El Chaar ◽  
Rafic Antonios ◽  
Mays El-Dairi ◽  
Baha’ Noureddin
Keyword(s):  
Refractive Error ◽  
Axial Length ◽  
Choroidal Thickness ◽  
Healthy Children ◽  
Spherical Equivalent ◽  
High Definition ◽  
Biometric Data ◽  
Ocular Abnormality ◽  
Thickness Measurements ◽  
Sd Oct

Objective.To report interocular differences in choroidal thickness in children using spectral domain optical coherence tomography (SD-OCT) and correlate findings with biometric data.Methods.This observational cross-sectional study included 91 (182 eyes) healthy children aged 6 to 17 years with no ocular abnormality except refractive error. After a comprehensive eye exam and axial length measurement, high definition macular scans were performed using SD-OCT. Two observers manually measured the choroidal thickness at the foveal center and at 1500 µm nasally, temporally, inferiorly, and superiorly. Interocular differences were computed; correlations with age, gender, refractive error, and axial length were performed.Results.Mean age was 10.40 ± 3.17 years; mean axial length and refractive error values were similar between fellow eyes. There was excellent correlation between the two observers’ measurements. No significant interocular differences were observed at any location. There was only a trend for right eyes to have higher values in all thicknesses, except the superior thickness. Most of the choroidal thickness measurements correlated positively with spherical equivalent but not with axial length, age, or gender.Conclusion.Choroidal thickness measurements in children as performed using SD-OCT revealed a high level of interobserver agreement and consistent interocular symmetry. Values correlated positively with spherical equivalent refraction.

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