scholarly journals Modern Aspects of Phototherapy for Atopic Dermatitis

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Sonja Alexandra Grundmann ◽  
Stefan Beissert
Keyword(s):  
Atopic Dermatitis ◽  
Cytokine Production ◽  
Antimicrobial Effect ◽  
Inflammatory Cells ◽  
Extracorporeal Photopheresis ◽  
Therapeutic Modalities ◽  
Narrowband Uvb ◽  
Proven Efficacy ◽  
Atopic Skin

Phototherapy has still great importance in the treatment of atopic dermatitis, though costs, compliance, and long-term risks narrow its relevance. In spite of its long history, up to now, the therapeutic regimes are mostly empirical. Narrowband UVB und UVA1 are the most frequently applied regimens in atopic dermatitis with proven efficacy. However, even for these modalities randomized prospective and controlled studies are still pending. Advances in photoimmunology and molecular biology had demonstrated that phototherapy targets inflammatory cells, alters cytokine production, and has a significant antimicrobial effect within atopic skin. This paper summarizes the current literature on the different regimes of phototherapy and also discusses therapeutic modalities like photochemotherapy and extracorporeal photopheresis. These more complex regimes should be restricted to severe cases of atopic dermatitis, which are refractory to topical treatment.

scholarly journals Narrow band UVB therapy versus tazarotene and narrow band UVB combination therapy in psoriasis: a comparative study

2018 ◽  
Vol 4 (3) ◽  
pp. 429
Author(s):  
Sowmiya R. ◽  
Nithya Gayathri Devi D.
Keyword(s):  
Combination Therapy ◽  
Narrow Band ◽  
Skin Lesions ◽  
Combination Group ◽  
Duration Of Treatment ◽  
Therapeutic Modalities ◽  
Plaque Type ◽  
Narrowband Uvb ◽  
Pasi Score

<p class="abstract"><strong>Background:</strong> Narrow band UVB phototherapy (NBUVB) is considered one of the most effective therapeutic modalities for patients with psoriasis. The long term side effects of narrowband UVB therapy have not been fully documented. There has been a great deal of interest in photo combination therapies that are capable of both reducing cumulative UVB doses and accelerating resolution of skin lesions. The aim of our study was to compare the efficacy and tolerability of NBUVB plus tazarotene combination therapy with NBUVB mono therapy.</p><p class="abstract"><strong>Methods:</strong> Forty patients with chronic plaque type psoriasis were taken up for the study and were randomly divided into two groups of 20 each. One group was treated with thrice-weekly NBUVB phototherapy and the other group received NBUVB phototherapy thrice weekly in addition to topical tazarotene once daily at bed time.<strong></strong></p><p class="abstract"><strong>Results:</strong> In the tazarotene combination group, the reduction in PASI score was more rapid. The duration of treatment and the mean cumulative dose of NBUVB was lesser in the tazarotene combination group. Irritation due to tazarotene was mild and combination of tazarotene with NBUVB was well tolerated.</p><p><strong>Conclusions:</strong> We concluded that combination of tazarotene with NBUVB was well tolerated and was significantly more effective than NBUVB phototherapy alone. </p>

scholarly journals Long‐term safety and efficacy of delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with atopic dermatitis

2019 ◽  
Vol 47 (2) ◽  
pp. 114-120 ◽  
Author(s):  
Hidemi Nakagawa ◽  
Osamu Nemoto ◽  
Atsuyuki Igarashi ◽  
Hidehisa Saeki ◽  
Ryusei Murata ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Kinase Inhibitor ◽  
Janus Kinase ◽  
Adult Patients ◽  
Janus Kinase Inhibitor ◽  
Safety And Efficacy

scholarly journals Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

Membranes ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 26
Author(s):  
Sara Metwally ◽  
Daniel P. Ura ◽  
Zuzanna J. Krysiak ◽  
Łukasz Kaniuk ◽  
Piotr K. Szewczyk ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Atopic Dermatitis ◽  
Mechanical Performance ◽  
Antibacterial Properties ◽  
Skin Condition ◽  
Fiber Morphology ◽  
Suitable Material ◽  
Hemp Oil ◽  
Skin Moisture

Atopic dermatitis (AD) is a chronic, inflammatory skin condition, caused by wide genetic, environmental, or immunologic factors. AD is very common in children but can occur at any age. The lack of long-term treatments forces the development of new strategies for skin regeneration. Polycaprolactone (PCL) is a well-developed, tissue-compatible biomaterial showing also good mechanical properties. In our study, we designed the electrospun PCL patches with controlled architecture and topography for long-term release in time. Hemp oil shows anti-inflammatory and antibacterial properties, increasing also the skin moisture without clogging the pores. It can be used as an alternative cure for patients that do not respond to traditional treatments. In the study, we tested the mechanical properties of PCL fibers, and the hemp oil spreading together with the release in time measured on skin model and human skin. The PCL membranes are suitable material as patches or bandages, characterized by good mechanical properties and high permeability. Importantly, PCL patches showed release of hemp oil up to 55% within 6 h, increasing also the skin moisture up to 25%. Our results confirmed that electrospun PCL patches are great material as oil carriers indicating a high potential to be used as skin patches for AD skin treatment.

scholarly journals Drug survival of systemic immunosuppressive treatments for atopic dermatitis in a long-term pediatric cohort

2021 ◽  
Author(s):  
Stine Elsgaard ◽  
Anne Kathrine Danielsen ◽  
Jacob P. Thyssen ◽  
Mette Deleuran ◽  
Christian Vestergaard
Keyword(s):  
Atopic Dermatitis ◽  
Drug Survival

Homoeopathic Treatment of Atopic Dermatitis in an Infant: A Case Report

2020 ◽  
Author(s):  
Baidurjya Bhattacharjee ◽  
Vanlalfakawmi Pachuau
Keyword(s):  
Atopic Dermatitis ◽  
Case Report ◽  
Lifetime Prevalence ◽  
Fair Chance

AbstractAtopic dermatitis (AD) is a common dermatological disorder in children, which is chronic and of a relapsing nature. It is very common in children, with a fair chance of lifetime prevalence of the disease. The following case is of a child 5 months of age who was suffering from AD since 2 months of age. After the first prescription, complaints were much improved. Following that, the child was treated with complex homoeopathic medicines by another physician, which aggravated the condition. Following stoppage of medicines due to an aggravation, a second remedy was thereafter prescribed that provided long-term relief to the patient.

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