scholarly journals Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Maral Tajerian ◽  
Magali Millecamps ◽  
Laura S. Stone
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Adverse Reactions ◽  
Therapeutic Outcome ◽  
Therapeutic Window ◽  
Fixed Dose ◽  
Null Mouse ◽  
Low Back ◽  
Pharmacological Agents

Chronic low back pain (LBP) is a debilitating condition associated with signs of axial and radiating pain. In humans with chronic LBP, opioids are often prescribed with varying outcomes and a multitude of side effects. Combination therapies, in which multiple pharmacological agents synergize to ameliorate pain without similar potentiation of adverse reactions, may be useful in improving therapeutic outcome in these patients. The SPARC-null mouse model of low back pain due to disc degeneration was used to assess the effects of opioid (morphine) and α2-adrenergic agonist (clonidine) coadministration on measures of axial and radiating pain. The results indicate that systemic morphine and clonidine, coadministered at a fixed dose of 100 : 1 (morphine : clonidine), show a synergistic interaction in reversing signs of axial LBP, in addition to improving the therapeutic window for radiating LBP. Furthermore, these improvements were observed in the absence of synergy in assays of motor function which are indicative of side effects such as sedation and motor incoordination. These data show that the addition of low-dose systemic clonidine improves therapeutic outcome in measures of both axial and radiating pain. Combination therapy could be of enormous benefit to patients suffering from chronic LBP.

THU0553 Influence of Obesity on Therapeutic Outcome in Patients with Non-Specific Subacute Low Back Pain

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A351.2-A351
Author(s):  
M. I. Terek ◽  
M. I. Zlatkovic-Svenda ◽  
N. Djurovic ◽  
G. L. Radunovic
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Therapeutic Outcome ◽  
Low Back ◽  
Subacute Low Back Pain

Mechanical Consequence of Induced Intervertebral Disc Degeneration in the SPARC-Null Mouse

2020 ◽  
Vol 143 (2) ◽  
Author(s):  
Mitchel C. Whittal ◽  
Sara Molladavoodi ◽  
Derek P. Zwambag ◽  
Magali Millecamps ◽  
Laura S. Stone ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Mechanical Tests ◽  
Null Mouse ◽  
Low Back ◽  
Spine Mechanics ◽  
Tension And Compression ◽  
In Series ◽  
Ivd Degeneration

Abstract Intervertebral disc (IVD) degeneration is associated with low back pain (LBP) and accompanied by mechanical changes to the spine. Secreted protein acidic and rich in cysteine (SPARC) is a protein that contributes to the functioning and maintenance of the extracellular matrix. SPARC-null mice display accelerated IVD degeneration and pain-associated behaviors. This study examined if SPARC-null mice also display altered spine mechanics as compared to wild-type (WT) mice. Lumbar spines from SPARC-null (n = 36) and WT (n = 18) mice aged 14–25 months were subjected to cyclic axial tension and compression to determine neutral zone (NZ) length and stiffness. Three separate mechanical tests were completed for each spine to determine the effect of the number of IVDs tested in series (one versus two versus three IVDs). SPARC-null spine NZs were both stiffer (p < 0.001) and smaller in length (p < 0.001) than WT spines. There was an effect of the number of IVDs tested in series for NZ length but not NZ stiffness when collapsed across condition (SPARC-null and WT). Correlation analysis revealed a weak negative correlation (r = −0.24) between age and NZ length in SPARC-null mice and a weak positive correlation (r = 0.30) between age and NZ stiffness in WT mice. In conclusion, SPARC-null mice had stiffer and smaller NZs than WT mice, regardless of the number of IVDs in series being tested. The increased stiffness of these IVDs likely influences mobility at these spinal joints thereby potentially contributing to low back pain.

Study of Analgesic Intake among Patients with Chronic Low Back Pain and Their Side Effects

2017 ◽  
Vol 69 (3) ◽  
pp. 2128-2132
Author(s):  
Molook Shebeeb Alotibi ◽  
Abdullah Ibrahim Saeed ◽  
Hussam Sunaid Dhaher Almuzaini
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Chronic Low Back Pain ◽  
Low Back

A Double-Blind Study of Topical Massage with Rado-Salil® Ointment in Mechanical Low-Back Pain

1987 ◽  
Vol 15 (3) ◽  
pp. 148-153 ◽  
Author(s):  
F. Ginsberg ◽  
J. P. Famaey
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Specific Treatment ◽  
Spontaneous Pain ◽  
Double Blind Study ◽  
Low Back ◽  
Double Blind ◽  
Lumbar Extension ◽  
Blind Manner

Forty patients with acute mechanical low-back pain were treated in a double-blind manner with either Rado-Salil® or placebo for 14 days. Statistically significant improvements in spontaneous pain, muscular contracture and in both the patient's and physician's opinions occurred by day 3. These improvements persisted at day 14 and, in addition, there were statistically significant improvements in the finger–floor distance and the degree of lumbar extension. Treatment with Rado-Salil® also allowed significant reduction in the use of oral analgesics. Only a few localized transient side-effects, requiring no specific treatment, were observed.

THU0344 The AGE Influence on Therapeutic Outcome in Patients with Subacute Low Back Pain

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 301.2-301
Author(s):  
M.I. Terek ◽  
M.I. Zlatkovic-Svenda ◽  
S.S. Novkovic ◽  
G.L. Radunovic
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Therapeutic Outcome ◽  
Low Back ◽  
Subacute Low Back Pain

scholarly journals Royal Jelly Supplementation Improves Menopausal Symptoms Such as Backache, Low Back Pain, and Anxiety in Postmenopausal Japanese Women

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Takashi Asama ◽  
Hidenori Matsuzaki ◽  
Shinobu Fukushima ◽  
Tomoki Tatefuji ◽  
Ken Hashimoto ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Postmenopausal Women ◽  
Royal Jelly ◽  
Oral Treatment ◽  
Statistical Significance ◽  
Japanese Women ◽  
Menopausal Symptoms ◽  
Low Back

Objectives. This study aimed to evaluate the effect of Royal Jelly (RJ) at a dose of 800 mg/day on menopausal symptoms in healthy Japanese postmenopausal women with placebo-controlled design. Material and Methods. A total of 42 healthy Japanese postmenopausal women have been recruited for this study. The subjects were randomized to oral treatment with either 800 mg of protease-digested lyophilized powder of RJ (enzyme-treated RJ) or placebo (800 mg of dextrin) daily for 12 weeks. The level of menopausal symptoms has been evaluated every 4 weeks, using menopausal symptoms questionnaire of Japanese women. Independent t-test was used to evaluate statistical significance of the treatment effects between the two groups. Results and Conclusion. All of the 42 women have completed the trial. There were significant differences related to the anxiety score (P=0.046) and backache and low back pain score (P=0.040) between 800 mg/day enzyme-treated RJ and placebo-treated groups after 12 weeks of administration, and no significant differences were found between the two groups in 4 weeks after intervention. No side effects were observed in either group. This study demonstrates that enzyme-treated RJ supplementation with doses of 800 mg/day is effective in relieving menopausal symptoms such as anxiety, backache, and low back pain in Japanese postmenopausal women.

scholarly journals Efficacy and safety of Ketoprofen Gel treatment in patients with low back pain

2021 ◽  
Vol 11 (1) ◽  
pp. 28-34
Author(s):  
V.V. Povoroznyuk ◽  
A.S. Musiienko ◽  
N.V. Zaverukha ◽  
A.A. Tkachuk
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Functional Capacity ◽  
Lumbar Region ◽  
Low Back ◽  
Group I ◽  
Gel Treatment ◽  
Systemic Side Effects

Background. The purpose was to study the effectiveness and safety of Ketoprofen gel (Fastum gel) therapy in patients with low back pain (LBP) caused by degenerative-dystrophic changes of the spine. Materials and methods. 24 males and females aged 50-69 years with LBP lasting over 14 days were examined, with a further division into two groups. Group I – 12 patients received thin ketoprofen applications on the lumbar region 2 times a day for 10 days. Group II – 12 patients who received thin applications of Vaseline on the same area 2 times a day for 10 days. Patients used the study drugs as a monotherapy. Examination was performed before the treatment initiation, after 10 and 20 days of treatment. Results. Patients receiving ketoprofen applications had a significantly reduced pain intensity registered by all four components of VAS and the Roland-Morris questionnaire. At the same time, the functional capacity by Schober (t = 3.54, p = 0.005) and Tomayer (t = 3.08, p = 0.01) tests was significantly improved. The quality of life according to the EuroQul-5D scale in patients who used the topical ketoprofen significantly increased by 45 % (t = 4.19, p = 0.002), and life expectancy according to the Oswestry questionnaire by 39.3 % after 10 days of treatment (t = 3.9, p = 0.002). 75 % of patients from the main group and 33.3 % from the compa­rison group assessed the effectiveness of treatment as high according to the Likert index. Neither group reported localized nor systemic side effects. Conclusions. Monotherapy of ketoprofen gel significantly reduced the intensity of pain and improved the functional capacity of patients with LBP. The absence of side effects during treatment indicates its high safety profile for patients.

scholarly journals COMPARISON OF DIFFERENT METHOD OF ANALGESIA IN AGED PATIENTSWITH CHRONIC LOW BACK PAIN

2017 ◽  
Vol 9 (4) ◽  
pp. 39-45
Author(s):  
G N Vasilieva ◽  
A L Linkov ◽  
N O Kukushkina ◽  
F I Dimitrienko ◽  
A E Karelov
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Prospective Study ◽  
Pain Intensity ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Aged Patients ◽  
Nonopioid Analgesic ◽  
Equal Effectiveness

Effectiveness of different methods of analgesia was studied in 34 aged patients suffering chronic low back pain. All patients were at age 60 to 86 and were randomized into N-group in which nefopam (60 mg rectally) was administrated and K-group that included patients who received ketoprofen (100 mg rectally). The end-points of this prospective study were decrease of pain intensity after analgesics administration, contentment of therapy, and characteristics of side effects of medications taking (twice daily for three days). We found that pain intensity decreases by 6,3±1,6 in N-group and 6,1±1,3 in K- group (p<0.05 in the both cases) and achieves 0,9±1,4 and 0,9±1,6 in N- and in K-group, respectively (p>0.05 in comparison between groups). No significant differences between groups were in estimation of therapy contentment. No side effects were registered. Thus, our data proved the equal effectiveness of central nonopioid analgesic nefopam and nonselective cyclooxygenise inhibitor ketoprofen for achievement of good analgesia in aged patients with chronic low back pain.

Sign in / Sign up

Export Citation Format

Share Document