scholarly journals Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma?

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Karaninder S. Mehta ◽  
Vikram K. Mahajan ◽  
Pushpinder S. Chauhan ◽  
Anju Lath Sharma ◽  
Vikas Sharma ◽  
...  

Basal cell carcinoma (BCC) accounts for 80% of all nonmelanoma skin cancers. Its metastasis is extremely rare, ranging between 0.0028 and 0.55 of all BCC cases. The usual metastasis to lymph nodes, lungs, bones, or skin is from the primary tumor situated in the head and neck region in nearly 85% cases. A 69-year-old male developed progressively increasing multiple, fleshy, indurated, and at places pigmented noduloulcerative plaques over back, chest, and left axillary area 4 years after wide surgical excision of a pathologically diagnosed basal cell carcinoma. The recurrence was diagnosed as infiltrative BCC and found metastasizing to skin, soft tissue and muscles, and pretracheal and axillary lymph nodes. Three cycles of chemotherapy comprising intravenouscisplatin (50 mg) and 5-florouracil (5-FU, 750 mg) on 2 consecutive days and repeated at every 21 days were effective. As it remains unclear whether metastatic BCC is itself a separate subset of basal cell carcinoma, we feel that early BCC localized at any site perhaps constitutes a biological continuum that may ultimately manifest with metastasis in some individuals and should be evaluated as such. Long-standing BCC is itself potentially at risk of recurrence/dissemination; it is imperative to diagnose and appropriately treat all BCC lesions at the earliest.

2014 ◽  
Vol 96 (7) ◽  
pp. e20-e21 ◽  
Author(s):  
AH Sadr ◽  
S de Kerviler ◽  
N Kang

Although basal cell carcinoma is a very common malignancy, metastasis from this tumour is extremely rare. For this reason, many plastic surgeons, dermatologists and physicians dealing with skin malignancies consider this as a locally invasive malignancy. We present a rare case of metastatic basal cell carcinoma manifested as a bronchial tumour. This case highlights the fact that despite basal cell carcinoma’s local invasive potential, the possibility of distant metastasis still exists and clinicians should therefore be cautious about interpreting extracutaneous symptoms. Chest physicians should always consider the possibility of this rare tumour in the lungs in patients with a history of large basal cell carcinomas in the head and neck region.


2015 ◽  
Vol 130 (2) ◽  
pp. 176-182 ◽  
Author(s):  
A Maimaiti ◽  
A Mijiti ◽  
A Yarbag ◽  
A Moming

AbstractBackground:Giant basal cell carcinoma, in which the tumour measures 5 cm or greater in diameter, is a very rare skin malignancy that accounts for less than 1 per cent of all basal cell tumours. Very few studies have reported on the incidence, resection and reconstruction of this lesion worldwide.Methods:In total, 17 patients with giant basal cell carcinoma of the head and neck region underwent surgical excision and reconstruction at our hospital. Medical charts were retrospectively reviewed and analysed.Results:The lesion was usually in the forehead, eyelid, lips or nasal-cheek region. The greatest diameter ranged from 5 to 11 cm, with 5–6 cm being the most common size at the time of presentation. All patients had their tumour resected and reconstructed in a single-stage procedure, mostly with a local advancement flap, and with no post-operative flap failure.Conclusion:Giant basal cell carcinoma of the head and neck can be successfully treated with a local flap in a single-stage approach.


Author(s):  
M.H. Roozeboom ◽  
K. Mosterd ◽  
V.J.L. Winnepenninckx ◽  
P.J. Nelemans ◽  
N.W.J. Kelleners-Smeets

Sign in / Sign up

Export Citation Format

Share Document