scholarly journals Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Marcel Cerqueira Cesar Machado ◽  
Ana Maria Mendonça Coelho ◽  
Luiz Augusto Carneiro D’Albuquerque ◽  
Sonia Jancar
Keyword(s):  
Acute Pancreatitis ◽  
Systemic Inflammation ◽  
Treatment Strategies ◽  
The Elderly ◽  
Multiple Organ ◽  
Low Grade ◽  
Multiple Organ Dysfunction ◽  
Older Subjects ◽  
Immunological System ◽  
Increased Susceptibility

Elderly patients show increased incidence of multiple organ dysfunction in acute pancreatitis possibly due to bacterial translocation. This is associated with increased susceptibility to infections in older people. Several reports have related this increased susceptibility to a proinflammatory status calledinflammaging, which decreases the capacity of the immunological system to respond to antigens. Cellular senescence also contributes to this low-grade chronic inflammation in older subjects. We discuss here the effect of ageing on systemic inflammation, focusing on that induced by acute pancreatitis and some of the mechanisms involved. It is important to understand the immunological changes in the elderly to adjust treatment strategies in order to reduce the morbidity and mortality associated with acute pancreatitis and other conditions that lead to systemic inflammation.

Multiple organ dysfunction associated with severe acute pancreatitis (SAP)

2001 ◽  
Vol 120 (5) ◽  
pp. A644-A645
Author(s):  
Kimmo I. Halonen ◽  
Ville Pettila ◽  
Ari K. Leppaniemi ◽  
Esko A. Kemppainen ◽  
Pauli A. Puolakkainen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Organ Dysfunction ◽  
Severe Acute Pancreatitis ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

scholarly journals New strategies in multiple organ dysfunction syndrometherapy for sepsis

2005 ◽  
Vol 133 (7-8) ◽  
pp. 379-383 ◽  
Author(s):  
Maja Surbatovic ◽  
Sonja Radakovic ◽  
Krsta Jovanovic ◽  
Predrag Romic
Keyword(s):  
Organ Dysfunction ◽  
Treatment Strategies ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Tight Control ◽  
Goal Directed Therapy ◽  
Early Goal Directed Therapy ◽  
Drotrecogin Alfa Activated ◽  
New Treatment ◽  
New Strategies

Despite more than 20 years of extensive research, sepsis and/or trauma induced multiple organ dysfunction syndrome (MODS) remain the chief cause of death in intensive care units, with mortality rates between 30% and 80%. Early goal-directed therapy (EGDT), use of drotrecogin alfa (activated), tight control of hyperglycaemia, and adrenal replacement therapy (low doses of corticosteroids)all constitute new treatment strategies. In future, a combination of therapies should be individually adjusted for each patient.

scholarly journals Protective Effect of Tetrandrine on Sodium Taurocholate-Induced Severe Acute Pancreatitis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Xian-lin Wu ◽  
Jie-xing Li ◽  
Zhen-dong Li ◽  
Da-sheng Liu ◽  
Su-hong Lu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Free Radical ◽  
Bile Duct ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Protective Effect ◽  
Severe Acute Pancreatitis ◽  
Sodium Taurocholate ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

Tet is a type of alkaloid extracted fromStephania tetrandra, and it has recently been demonstrated that Tet can protect against inflammation and free radical injury and inhibit the release of inflammatory mediators. The present study was designed to observe the protective effect of Tet on sodium taurocholate-induced severe acute pancreatitis (SAP). The rat model of SAP was induced by retrograde bile duct injection of sodium taurocholate and then treated with Verapamil and Tet. The results showed that Tet can reduce NF-κB activation in pancreas issue, inhibit the SAP cascade, and improve SAP through inducing pancreas acinar cell apoptosis and stabilizing intracellular calcium in the pancreas, thus mitigating the damage to the pancreas. Our study revealed that Tet may reduce systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS) to protect against damage, and these roles may be mediated through the NF-κB pathway to improve the proinflammatory/anti-inflammatory imbalance.

Multiple organ dysfunction associated with severe acute pancreatitis*

2002 ◽  
Vol 30 (6) ◽  
pp. 1274-1279 ◽  
Author(s):  
Kimmo I. Halonen ◽  
Ville Pettilä ◽  
Ari K. Leppäniemi ◽  
Esko A. Kemppainen ◽  
Pauli A. Puolakkainen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Organ Dysfunction ◽  
Severe Acute Pancreatitis ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction
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