scholarly journals The Influence of Endothelial Function and Myocardial Ischemia on Peak Oxygen Consumption in Patients with Coronary Artery Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Simon L. Bacon ◽  
Andrew Sherwood ◽  
Alan Hinderliter ◽  
Annik Plourde ◽  
Lee Pierson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Oxygen Consumption ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Endothelial Function ◽  
Exercise Stress ◽  
Peak Oxygen Consumption ◽  
Peak Exercise ◽  
No Production ◽  
Artery Disease

Impaired endothelial function has been shown to limit exercise in coronary artery disease (CAD) patients and has been implicated in myocardial ischemia. However, the association of endothelial function and ischemia on peak exercise oxygen consumption (VO2) has not been previously reported. A total of 116 CAD patients underwent standard exercise stress testing, during which VO2was measured. On a separate day, endothelial-dependent and -independent function were assessed by ultrasound using flow-mediated arterial vasodilation (FMD) and sublingual glyceryl trinitrate administration (GTNMD) of the brachial artery. Patients with exercise-induced myocardial ischemia had lower FMD than nonischemic patients (3.64±0.57versus4.98±0.36,P=.050), but there was no difference in GTNMD (14.11±0.99versus15.47±0.63,P=.249). Analyses revealed that both FMD (P=.006) and GTNMD (P=.019) were related to peak VO2. However, neither the presence of ischemia (P=.860) nor the interaction of ischemia with FMD (P=.382) and GTNMD (P=.151) was related to peak VO2. These data suggest that poor endothelial function, potentially via impaired NO production and smooth muscle dysfunction, may be an important determinant of exercise capacity in patients with CAD, independent of myocardial ischemia.

scholarly journals Vasomotor function of endothelium in patients with coronary artery disease and ventricular arrhythmias occurring during myocardial ischemia

2007 ◽  
Vol 13 (4) ◽  
pp. 297-307
Author(s):  
M. M. Rudakov
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Peak Exercise ◽  
Test Duration ◽  
Vasomotor Function ◽  
Group I ◽  
Ergometer Exercise ◽  
Group Ii ◽  
Artery Disease

Purpose: To compare vasomotor endothelial function in patients with coronary artery disease (CAD) with and without VA occurring during myocardial ischemia. Methods: We studied 48 patients with CAD who had electrocardiographic signs of ischemia during ergometer exercise testing. All patients were divided into 2 equal groups: group I with VA occurred at peak exercise or during recovery and group II without VA. Exercise test duration was similar in the groups I and II. None of the patients had severe arterial hypertension, diabetes mellitus or signs of heart failure. Assessment of endothelial-dependent flow-mediated vasodilation (FMD) and endothelial-independent nitroglycerin-mediated vasodilation of brachial artery (BA) was performed using high-resolution ultrasound. Plasma endothelin-1 levels were measured by immunoassay method. Results: FMD of BA was lower and duration of ischemic changes of ECG during recovery was greater in the group I compared with group II. There were no significant differences in plasma ET-1 levels among the groups I and II. Conclusions: The patients with CAD and VA occurring during ischemia have FMD impaired to a greater degree and duration of ischemic changes of ECG in recovery longer compared with ones without VA.

scholarly journals Myocardial ischemia and left ventricular diastolic dysfunction in HIV infected patients and asymptomatic for coronary artery disease

2021 ◽  
Vol 10 (11) ◽  
pp. e301101119756
Author(s):  
Willams de Matos Moraes ◽  
Úrsula Maria Moreira Costa Burgos ◽  
Antônio Carlos Sobral Sousa ◽  
Ângela Maria da Silva ◽  
João Eduardo Andrade Tavares de Aguiar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Exercise Stress ◽  
Laboratory Evaluation ◽  
Ventricular Diastolic Dysfunction ◽  
Artery Disease

Highly active antiretroviral therapy (HAART) allows chronicity of AIDS evolution, leading to association of other pathologies such as coronary artery disease (CAD). Myocardial ischemia (MI) and left ventricular diastolic dysfunction (LVDD) evaluation in HIV-infected patients may favor primary prevention of CAD. The study aimed to evaluate frequencies of MI and LVDD in the population living with the human immunodeficiency virus (PLHIV) and asymptomatic for CAD. We analyzed data from 110 HIV-infected patients who underwent clinical and laboratory evaluation, treadmill exercise stress test, and transthoracic echocardiogram, and compared it with 2,619 healthy individuals from the control group (non-HIV and non-CAD), selected from the database. HIV-infected patients presented lower average age (51.5 ± 7.7), systemic arterial hypertension (28.0%) and dyslipidemia frequencies (32.0%). On the other hand, their MI frequency was twice as high (14.7%); and diastolic dysfunction (DD) percentage was higher in ischemic patients (45.5%). In the HIV-infected group, MI frequency was 10.0%, while that of DD was 18.2%. MI was twice as frequent among HIV infected patients compared to uninfected, despite lower frequency of risk factors for CAD. Non-ischemic patients living with HIV had a frequency of DD more than twice compared to the control individuals.

The caregene study: muscle-specific creatine kinase gene and aerobic power in coronary artery disease

2005 ◽  
Vol 12 (4) ◽  
pp. 415-417 ◽  
Author(s):  
Johan Defoor ◽  
Kevin Martens ◽  
Gert Matthijs ◽  
Dominika Zieliñska ◽  
Dirk Schepers ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Creatine Kinase ◽  
Oxygen Consumption ◽  
Coronary Artery ◽  
Physical Training ◽  
Aerobic Power ◽  
Peak Oxygen Consumption ◽  
Kinase Gene ◽  
Caucasian Patients ◽  
Artery Disease

In 927 biologically unrelated Caucasian patients with coronary artery disease it was investigated whether the NcoI restriction fragment length polymorphism of the muscle-specific creatine kinase (CKMM) gene is associated with aerobic power and with the response to physical training. Physical training significantly ( P<0.001) increased peak oxygen consumption in the GG, AG and AA NcoI genotypes. Covariate-adjusted peak oxygen consumption at baseline, after training and the response to training were not different across CKMM NcoI genotypes.

scholarly journals Role of Exercise Echocardiography to Predict Coronary Artery Disease

2021 ◽  
Vol 17 (2) ◽  
pp. 114-117
Author(s):  
Pallob Kumar Biswas ◽  
Fakhrul Islam Khaled ◽  
Tanjima Parvin ◽  
Manzoor Mahmood ◽  
DMM Faruque Osmany ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Predictive Value ◽  
Stress Echocardiography ◽  
Wall Motion ◽  
Exercise Stress ◽  
Peak Exercise ◽  
Exercise Echocardiography ◽  
Artery Disease

Background: Coronary artery disease (CAD) is predicted to be the most common cause of death globally. Early detection of coronary artery disease and adequate management can reduce CAD related morbidity and mortality. Various non-invasive procedures have been developed to diagnose CAD. Stress echocardiography, myocardial perfusion (SPECT) and cardiac MRI are accepted as useful tools for evaluation of inducible myocardial ischaemia in intermediate risk group patient documented by pre test probability. Among them exercise echocardiography is a remarkable physiological, safe, feasible and cost effective. Objective: To see the role of exercise echocardiography to predict CAD. Materials and methods: This cross sectional study was conducted in University Cardiac Center (UCC), BSMMU. This study include the patients who are appointed for exercise tolerance test (ETT). Echocardiographic wall motion study was recorded at rest and after peak exercise and analyzed to diagnosis the regional wall motion abnormality. Specific CAD was confirmed by coronary angiogram. Results: A total of 40 patients were included in the study from the patients who are appointed for ETT. Patients diagnosed as CAD has the mean age of 50.6 ± 9.7 years and majority of the patients were male (72.5%). Sensitivity, specificity, positive predictive value and negative predictive value of exercise echocardiography were 85.5%, 76.9%, 88.5% and 71.4% respectively in predicting coronary artery disease by exercise echocardiography. The predominant risk factors was hypertension (40.0%) followed by diabetes mellitus, smoking, dyslipidaemia and family H/O CAD were significantly associated with the development of CAD in the study subjects. Conclusion: Treadmill exercise stress echocardiography demonstrates high significance for diagnosis of CAD. University Heart Journal Vol. 17, No. 2, Jul 2021; 114-117

Contribution of the peak exercise QT dispersion to the accuracy of an exercise test during the evaluation of coronary artery disease

2000 ◽  
Vol 55 (6) ◽  
pp. 335-339 ◽  
Author(s):  
Mehmet ÜLGEN ◽  
Aziz KARADEDE ◽  
Sait ALAN ◽  
A. Vahip TEMAMOĞULARI ◽  
Aziz KARABULUT ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Exercise Test ◽  
Qt Dispersion ◽  
Peak Exercise ◽  
Artery Disease
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