scholarly journals Semantic and Phonemic Verbal Fluency in Parkinson’s Disease: Influence of Clinical and Demographic Variables

2012 ◽  
Vol 25 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Ignacio Obeso ◽  
Enrique Casabona ◽  
Maria Luisa Bringas ◽  
Lázaro Álvarez ◽  
Marjan Jahanshahi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Verbal Fluency ◽  
Executive Dysfunction ◽  
Demographic Variables ◽  
Semantic Verbal Fluency ◽  
Phonemic Fluency ◽  
Main Components ◽  
Depression Education ◽  
Deep Brain

Changes of cognitive function in PD have been extensively documented and defined as a ‘frontal’ type executive dysfunction. One of the main components of this executive dysfunction is the impairment of verbal fluency. The aim of the present study was to assess semantic and phonemic fluency in a large sample of PD patients and to investigate the effect of clinical and sociodemographic variables on verbal fluency in this patient group.Three hundred patients with idiopathic Parkinson's disease who were consecutive referrals to our clinic and 50 age and education matched healthy controls completed the phonemic and semantic verbal fluency tasks. Both phonemic and semantic verbal fluency were significantly impaired in PD patients relative to matched controls. Stage of illness, presence of depression, education and age influenced verbal fluency measures. Regression analyses established that global measures of cognitive ability (MMSE) and executive function (FAB) and side of onset of motor symptoms predicted 36–37% of variance of phonemic or semantic verbal fluency measures. Thus, future studies aimed at assessing cognitive functioning in PD patients treated by deep brain stimulation (DBS) should adequately take into account several factors (stage of illness, depression, executive functioning) which may potentially influence performance on verbal fluency tasks.

Automated Indices of Clustering and Switching of Semantic Verbal Fluency in Parkinson’s Disease

2018 ◽  
Vol 24 (10) ◽  
pp. 1047-1056 ◽  
Author(s):  
Delaram Farzanfar ◽  
Marta Statucka ◽  
Melanie Cohn
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Construct Validity ◽  
Verbal Fluency ◽  
Executive Dysfunction ◽  
Semantic Knowledge ◽  
Neuropsychological Measures ◽  
Semantic Verbal Fluency ◽  
Fine Grained ◽  
Computational Data

AbstractObjectives: Deficits in semantic verbal fluency (SVF) can stem from dysfunction of an executive control system and/or of semantic knowledge. Previous analyses of SVF responses were devised to characterize these two components including switching and mean cluster size (MCS) indices, but these rely on subjective experimenter-based assessment of the words’ relatedness. To address this limitation, computational data-driven SVF indices have been developed. Our aim is to assess the validity and usefulness of these automated indices in the context of cognitive decline in Parkinson’s disease (PD). Methods: This is a retrospective study including 50 advanced PD patients with (n=28) or without (n=22) mild cognitive impairment (PD-MCI). We analyzed animal SVF outputs using an automated computational approach yielding switching, MCS, and cumulative relatedness (CuRel) indices. We compared these indices to the classic experimenter-based switching and MCS indices to assess concurrent validity, and against neuropsychological measures of executive functioning and semantic knowledge to assess construct validity. We also examined whether these indices were impaired and predicted PD-MCI. Results: Automated switching indices, but not MCS or CuRel, showed evidence of concurrent and construct validity, and characterized individual difference in advanced PD. Automated switching indices also outperformed the experimenter-dependent index in predicting the presence of PD-MCI. Conclusion: Computational methods hold promise as fine-grained, unbiased indices reflecting the executive component of SVF, but none of the methods provided valid measures of semantic knowledge in PD. Our data also confirm that SVF are not adequate tests of semantic memory in patients with executive dysfunction such as PD. (JINS, 2018, 24, 1047–1056)

scholarly journals Different outcomes of phonemic verbal fluency in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation

2017 ◽  
Vol 75 (4) ◽  
pp. 216-220 ◽  
Author(s):  
Aline Juliane Romann ◽  
Bárbara Costa Beber ◽  
Maira Rozenfeld Olchik ◽  
Carlos R M. Rieder
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Verbal Fluency ◽  
Phonemic Fluency ◽  
Phonemic Verbal Fluency ◽  
Stn Dbs ◽  
Deep Brain

ABSTRACT Subthalamic nucleus deep brain stimulation (STN-DBS) is a surgical technique to treat motor symptoms in patients with Parkinson’s disease (PD). Studies have shown that STN-DBS may cause a decline in verbal fluency performance. We aimed to verify the effects of STN-DBS on the performance of phonemic verbal fluency in Brazilian PD patients. Sixteen participants were evaluated on the Unified Parkinson’s Disease Rating Scale - Part III and for phonemic fluency (“FAS” version) in the conditions of on- and off-stimulation. We identified two different patterns of phonemic verbal fluency outcomes. The results indicate that there may be no expected pattern of effect of bilateral STN-DBS in the phonemic fluency, and patients may present with different outcomes for some reason not well understood.

Verbal fluency in Parkinson's disease: results of a 2-min fluency test

2006 ◽  
Vol 18 (1) ◽  
pp. 38-41 ◽  
Author(s):  
B. Scholtissen ◽  
J. Dijkstra ◽  
J. Reithler ◽  
A. F. G. Leentjens
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Functioning ◽  
Verbal Fluency ◽  
Healthy Controls ◽  
Impaired Performance ◽  
Phonemic Fluency ◽  
Retrieval Strategies ◽  
Fluency Task ◽  
Fluency Test

Background:Patients suffering from Parkinson's disease (PD) are often reported to have an impaired performance on tests measuring executive functioning, such as fluency tasks.Aim:To investigate whether verbal fluency is impaired in PD patients (n = 25) compared with healthy controls (n = 15) using a 2-min semantic and phonemic verbal fluency test. A 2-min version of the fluency task was used to allow for more switches between clusters to study retrieval strategies more adequately.Results:No differences in performance on both semantic and phonemic fluency tasks between the PD patients and the control persons were found. Moreover, both groups appeared to use the same retrieval strategies.Conclusion:Patients suffering from PD appear to use the same strategies for producing words as healthy controls do. Different pathways may be involved in switching clusters during the fluency task than in other types of switching that may be impaired in PD, such as motor switching and concept-shifting.

Clustering and switching on verbal fluency tests in Alzheimer's and Parkinson's disease

1998 ◽  
Vol 4 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Angela K. Troyer ◽  
Morris Moscovitch ◽  
Gordon Winocur ◽  
Larry Leach ◽  
and Morris Freedman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Verbal Fluency ◽  
Semantic Fluency ◽  
Alzheimer Type ◽  
Control Groups ◽  
Respective Control ◽  
Phonemic Fluency ◽  
Differential Pattern ◽  
Pattern Of Performance

Two components of verbal fluency performance—clustering (i.e., generating words within subcategories) and switching (i.e., shifting between subcategories)—were examined in patients with dementia of the Alzheimer type (DAT), patients with dementia with Parkinson's disease (DPD), nondemented patients with Parkinson's disease (NPD), and demographically matched controls. The DAT and DPD groups were impaired in the number of words generated on both phonemic and semantic fluency. The DAT group produced smaller clusters on both tasks and switched less often on semantic fluency than controls. The DPD group switched less often on both tasks and produced smaller clusters on phonemic fluency than controls. The NPD group was not impaired on any fluency variable. Thus, the total number of words generated on phonemic and semantic fluency did not discriminate the dementia groups from their respective control groups, but measures of clustering and switching did. This differential pattern of performance provides evidence for the potential usefulness of measures of switching and clustering in the assessment of dementia. (JINS, 1998, 4, 137–143.)

P2-61. Evaluation of verbal fluency in Parkinson’s disease patients with deep brain stimulation

2013 ◽  
Vol 124 (8) ◽  
pp. e37
Author(s):  
Tsubasa Sada ◽  
Yuka Watanabe ◽  
Madoka Okamura ◽  
Kenichi Hashimoto ◽  
Koichi Hirata
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Verbal Fluency ◽  
Deep Brain

scholarly journals The Verbal Fluency Decline After Deep Brain Stimulation in Parkinson's Disease: Is There an Influence of Age?

2015 ◽  
Vol 3 (1) ◽  
pp. 48-52
Author(s):  
Vitalii V. Cozac ◽  
Nadine Schwarz ◽  
Habib Bousleiman ◽  
Menorca Chaturvedi ◽  
Michael M. Ehrensperger ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Verbal Fluency ◽  
Deep Brain

Decline in Verbal Fluency After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A Microlesion Effect of the Electrode Trajectory?

2015 ◽  
Vol 5 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Floriane Le Goff ◽  
Stéphane Derrey ◽  
Romain Lefaucheur ◽  
Alaina Borden ◽  
Damien Fetter ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Verbal Fluency ◽  
Deep Brain

scholarly journals Deep Brain Stimulation Frequency of the Subthalamic Nucleus Affects Phonemic and Action Fluency in Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Valéria de Carvalho Fagundes ◽  
Carlos R. M. Rieder ◽  
Aline Nunes da Cruz ◽  
Bárbara Costa Beber ◽  
Mirna Wetters Portuguez
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
High Frequency ◽  
Verbal Fluency ◽  
Low Frequency ◽  
Stn Dbs ◽  
Deep Brain

Introduction.Deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson’s disease (PD) has been linked to a decline in verbal fluency. The decline can be attributed to surgical effects, but the relative contributions of the stimulation parameters are not well understood. This study aimed to investigate the impact of the frequency of STN-DBS on the performance of verbal fluency tasks in patients with PD.Methods.Twenty individuals with PD who received bilateral STN-DBS were evaluated. Their performances of verbal fluency tasks (semantic, phonemic, action, and unconstrained fluencies) upon receiving low-frequency (60 Hz) and high-frequency (130 Hz) STN-DBS were assessed.Results.The performances of phonemic and action fluencies were significantly different between low- and high-frequency STN-DBS. Patients showed a decrease in these verbal fluencies for high-frequency STN-DBS.Conclusion.Low-frequency STN-DBS may be less harmful to the verbal fluency of PD patients.

scholarly journals Does Quantitative Electroencephalography Refine Preoperative Cognitive Assessment in Parkinson’s Disease Patients Treated with Deep Brain Stimulation? A Follow-Up Study

2021 ◽  
pp. 1-8
Author(s):  
Christian Saleh ◽  
Antonia Meyer ◽  
Menorca Chaturvedi ◽  
Selina Beltrani ◽  
Ute Gschwandtner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Cognitive Performance ◽  
Brain Stimulation ◽  
Verbal Fluency ◽  
Quantitative Electroencephalography ◽  
Cognitive Score ◽  
Increased Risk ◽  
Deep Brain

<b><i>Objective:</i></b> Deep brain stimulation (DBS) in Parkinson’s disease (PD) is associated with an increased risk of post-operative cognitive deterioration. Preoperative neuropsychological testing can be affected and limited by the patient’s collaboration in advanced disease. The purpose of this study was to determine whether preoperative quantitative electroencephalography (qEEG) may be a useful complementary examination technique during preoperative assessment to predict cognitive changes in PD patients treated with DBS. <b><i>Methods:</i></b> We compared the cognitive performance of 16 PD patients who underwent bilateral subthalamic nucleus DBS to the performance of 15 PD controls (matched for age, sex, and education) at baseline and at 24 months. Cognitive scores were calculated for all patients across 5 domains. A preoperative 256-channel resting EEG was recorded from each patient. We computed the global relative power spectra. Correlation and linear regression models were used to assess associations of preoperative EEG measures with post-operative cognitive scores. <b><i>Results:</i></b> Slow waves (relative delta and theta band power) were negatively correlated with post-operative cognitive performance, while faster waves (alpha 1) were strongly positively correlated with the same scores (the overall cognitive score, attention, and executive function). Linear models revealed an association of delta power with the overall cognitive score (<i>p</i> = 0.00409, adjusted <i>R</i><sup>2</sup> = 0.6341). Verbal fluency (VF) showed a significant decline after DBS surgery, which was correlated with qEEG measures. <b><i>Conclusions:</i></b> To analyse the side effects after DBS in PD patients, the most important parameter is verbal fluency capacity. In addition, correlation with EEG frequency bands might be useful to detect particularly vulnerable patients for cognitive impairment and be supportive in the selection process of patients considered for DBS.

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