scholarly journals Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Tsung-Han Tsai ◽  
Chao Zhou ◽  
Hsiang-Chieh Lee ◽  
Yuankai K. Tao ◽  
Osman O. Ahsen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Radiofrequency Ablation ◽  
Treatment Efficacy ◽  
Structural Changes ◽  
Early Cancer ◽  
Imaging Modality ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Treatment Groups ◽  
Ideal Tool

Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260 μm depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment.

In vivo three dimensional optical coherence tomography. A novel imaging modality to visualize the edge vascular response

2013 ◽  
Vol 164 (3) ◽  
pp. e35-e37 ◽  
Author(s):  
Bill D. Gogas ◽  
Takashi Muramatsu ◽  
Hector M. Garcia-Garcia ◽  
Christos V. Bourantas ◽  
Niels R. Holm ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Imaging Modality ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Vascular Response

Tu1951 Imaging the Dynamics of Radiofrequency Ablation Using Ultrahigh-Speed Three-Dimensional Optical Coherence Tomography

2013 ◽  
Vol 144 (5) ◽  
pp. S-889
Author(s):  
Hsiang-Chieh Lee ◽  
Jonathan J. Liu ◽  
Tsung-Han Tsai ◽  
Benjamin Potsaid ◽  
Martin F. Kraus ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Radiofrequency Ablation ◽  
Three Dimensional ◽  
Optical Coherence

scholarly journals Optical Coherence Tomography for Patients with Developmental Disabilities: A Preliminary Study

Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 7940
Author(s):  
Kimberly Espinoza ◽  
Juri Hayashi ◽  
Yasushi Shimada ◽  
Junji Tagami ◽  
Alireza Sadr
Keyword(s):  
Optical Coherence Tomography ◽  
Developmental Disabilities ◽  
Rating Scale ◽  
Imaging Modality ◽  
Three Dimensional ◽  
Prototype System ◽  
Optical Coherence ◽  
Persons With Disabilities ◽  
Dental Radiographs ◽  
Pain Rating Scale

Dental radiographs are essential for diagnosis and treatment planning, but are sometimes difficult to acquire for patients with developmental disabilities (PDD). Optical Coherence Tomography (OCT) is a non-ionizing imaging modality that has the potential application as an alternative to dental radiographs for PDD. This study aimed to determine the feasibility of intraoral OCT imaging for PDD. Ten participants were recruited in the Dental Education in the Care of Persons with Disabilities (DECOD) Clinic to explore the utility of dental OCT. The prototype system (Yoshida Dental) creates in-depth and three-dimensional images of teeth. The participants indicated their degree of pain during imaging on the Wong-Baker FACES Pain Rating Scale, and the degree of discomfort after imaging on a visual analog scale. OCT can be used for patients with developmental disabilities with minimal levels of pain and discomfort, without ionizing radiation.

scholarly journals Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

2019 ◽  
Vol 9 (10) ◽  
pp. 2100 ◽  
Author(s):  
Johanna Gesperger ◽  
Antonia Lichtenegger ◽  
Thomas Roetzer ◽  
Marco Augustin ◽  
Danielle J. Harper ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Amyloid Beta ◽  
Cross Sections ◽  
Imaging Modality ◽  
Three Dimensional ◽  
Brain Regions ◽  
Optical Coherence ◽  
Amyloid Beta Protein ◽  
Tissue Sections ◽  
Cortical Regions

One key hallmark of Alzheimer’s disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. For a definitive diagnosis of AD, post-mortem histological analysis, including sectioning and staining of different brain regions, is required. Here, we present optical coherence tomography (OCT) as a tissue-preserving imaging modality for the visualization of amyloid-beta plaques and compare their contrast in intensity- and polarization-sensitive (PS) OCT. Human brain samples of eleven patients diagnosed with AD were imaged. Three-dimensional PS-OCT datasets were acquired and plaques were manually segmented in 500 intensity and retardation cross-sections per patient using the freely available ITK-SNAP software. The image contrast of plaques was quantified. Histological staining of tissue sections from the same specimens was performed to compare OCT findings against the gold standard. Furthermore, the distribution of plaques was evaluated for intensity-based OCT, PS-OCT and the corresponding histological amyloid-beta staining. Only 5% of plaques were visible in both intensity and retardation segmentations, suggesting that different types of plaques may be visualized by the two OCT contrast channels. Our results indicate that multicontrast OCT imaging might be a promising approach for a tissue-preserving visualization of amyloid-beta plaques in AD.

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