Optical Coherence Tomography for Patients with Developmental Disabilities: A Preliminary Study

Dental radiographs are essential for diagnosis and treatment planning, but are sometimes difficult to acquire for patients with developmental disabilities (PDD). Optical Coherence Tomography (OCT) is a non-ionizing imaging modality that has the potential application as an alternative to dental radiographs for PDD. This study aimed to determine the feasibility of intraoral OCT imaging for PDD. Ten participants were recruited in the Dental Education in the Care of Persons with Disabilities (DECOD) Clinic to explore the utility of dental OCT. The prototype system (Yoshida Dental) creates in-depth and three-dimensional images of teeth. The participants indicated their degree of pain during imaging on the Wong-Baker FACES Pain Rating Scale, and the degree of discomfort after imaging on a visual analog scale. OCT can be used for patients with developmental disabilities with minimal levels of pain and discomfort, without ionizing radiation.

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In vivo three dimensional optical coherence tomography. A novel imaging modality to visualize the edge vascular response

International Journal of Cardiology ◽

10.1016/j.ijcard.2012.09.161 ◽

2013 ◽

Vol 164 (3) ◽

pp. e35-e37 ◽

Cited By ~ 5

Author(s):

Bill D. Gogas ◽

Takashi Muramatsu ◽

Hector M. Garcia-Garcia ◽

Christos V. Bourantas ◽

Niels R. Holm ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Imaging Modality ◽

Three Dimensional ◽

Optical Coherence ◽

Vascular Response

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Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography

Gastroenterology Research and Practice ◽

10.1155/2012/684832 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 15

Author(s):

Tsung-Han Tsai ◽

Chao Zhou ◽

Hsiang-Chieh Lee ◽

Yuankai K. Tao ◽

Osman O. Ahsen ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Radiofrequency Ablation ◽

Treatment Efficacy ◽

Structural Changes ◽

Early Cancer ◽

Imaging Modality ◽

Three Dimensional ◽

Optical Coherence ◽

Treatment Groups ◽

Ideal Tool

Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260 μm depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment.

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Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

Applied Sciences ◽

10.3390/app9102100 ◽

2019 ◽

Vol 9 (10) ◽

pp. 2100 ◽

Cited By ~ 2

Author(s):

Johanna Gesperger ◽

Antonia Lichtenegger ◽

Thomas Roetzer ◽

Marco Augustin ◽

Danielle J. Harper ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Amyloid Beta ◽

Cross Sections ◽

Imaging Modality ◽

Three Dimensional ◽

Brain Regions ◽

Optical Coherence ◽

Amyloid Beta Protein ◽

Tissue Sections ◽

Cortical Regions

One key hallmark of Alzheimer’s disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. For a definitive diagnosis of AD, post-mortem histological analysis, including sectioning and staining of different brain regions, is required. Here, we present optical coherence tomography (OCT) as a tissue-preserving imaging modality for the visualization of amyloid-beta plaques and compare their contrast in intensity- and polarization-sensitive (PS) OCT. Human brain samples of eleven patients diagnosed with AD were imaged. Three-dimensional PS-OCT datasets were acquired and plaques were manually segmented in 500 intensity and retardation cross-sections per patient using the freely available ITK-SNAP software. The image contrast of plaques was quantified. Histological staining of tissue sections from the same specimens was performed to compare OCT findings against the gold standard. Furthermore, the distribution of plaques was evaluated for intensity-based OCT, PS-OCT and the corresponding histological amyloid-beta staining. Only 5% of plaques were visible in both intensity and retardation segmentations, suggesting that different types of plaques may be visualized by the two OCT contrast channels. Our results indicate that multicontrast OCT imaging might be a promising approach for a tissue-preserving visualization of amyloid-beta plaques in AD.

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A review of optical coherence tomography in breast cancer

Photonics and Lasers in Medicine ◽

10.1515/plm-2014-0013 ◽

2014 ◽

Vol 3 (3) ◽

Cited By ~ 19

Author(s):

Loretta Scolaro ◽

Robert A. McLaughlin ◽

Brendan F. Kennedy ◽

Christobel M. Saunders ◽

David D. Sampson

Keyword(s):

Breast Cancer ◽

Optical Coherence Tomography ◽

Medical Imaging ◽

Imaging Modality ◽

Three Dimensional ◽

Tissue Structure ◽

Optical Coherence ◽

Micro Scale ◽

Bulk Tissue

AbstractOptical coherence tomography (OCT) is a medical imaging modality that opens up new opportunities for imaging in breast cancer. It provides two- and three-dimensional micro-scale images of tissue structure from bulk tissue,

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Non-invasive three-dimensional thickness analysis of oral epithelium based on optical coherence tomography—development and diagnostic performance

Heliyon ◽

10.1016/j.heliyon.2021.e06645 ◽

2021 ◽

Vol 7 (4) ◽

pp. e06645

Author(s):

Charlotte Theresa Trebing ◽

Sinan Sen ◽

Stefan Rues ◽

Christopher Herpel ◽

Maria Schöllhorn ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diagnostic Performance ◽

Three Dimensional ◽

Oral Epithelium ◽

Optical Coherence ◽

Non Invasive

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Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography

Experimental Biology and Medicine ◽

10.1177/15353702211028540 ◽

2021 ◽

pp. 153537022110285

Author(s):

Hao Zhou ◽

Tommaso Bacci ◽

K Bailey Freund ◽

Ruikang K Wang

Keyword(s):

Optical Coherence Tomography ◽

Three Dimensional ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Full Thickness ◽

Swept Source ◽

Automated Method ◽

Choroidal Imaging ◽

Choroidal Vasculature ◽

Choroidal Vessels

The choroid provides nutritional support for the retinal pigment epithelium and photoreceptors. Choroidal dysfunction plays a major role in several of the most important causes of vision loss including age-related macular degeneration, myopic degeneration, and pachychoroid diseases such as central serous chorioretinopathy and polypoidal choroidal vasculopathy. We describe an imaging technique using depth-resolved swept-source optical coherence tomography (SS-OCT) that provides full-thickness three-dimensional (3D) visualization of choroidal anatomy including topographical features of individual vessels. Enrolled subjects with different clinical manifestations within the pachychoroid disease spectrum underwent 15 mm × 9 mm volume scans centered on the fovea. A fully automated method segmented the choroidal vessels using their hyporeflective lumens. Binarized choroidal vessels were rendered in a 3D viewer as a vascular network within a choroidal slab. The network of choroidal vessels was color depth-encoded with a reference to the Bruch’s membrane segmentation. Topographical features of the choroidal vasculature were characterized and compared with choroidal imaging obtained with indocyanine green angiography (ICGA) from the same subject. The en face SS-OCT projections of the larger choroid vessels closely resembled to that obtained with ICGA, with the automated SS-OCT approach proving additional depth-encoded 3D information. In 16 eyes with pachychoroid disease, the SS-OCT approach added clinically relevant structural details, including choroidal thickness and vessel depth, which the ICGA studies could not provide. Our technique appears to advance the in vivo visualization of the full-thickness choroid, successfully reveals the topographical features of choroidal vasculature, and shows potential for further quantitative analysis when compared with other choroidal imaging techniques. This improved visualization of choroidal vasculature and its 3D structure should provide an insight into choroid-related disease mechanisms as well as their responses to treatment.

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Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging

Journal of VitreoRetinal Diseases ◽

10.1177/2474126421997335 ◽

2021 ◽

pp. 247412642199733

Author(s):

Kyle D. Kovacs ◽

M. Abdallah Mahrous ◽

Luis Gonzalez ◽

Benjamin E. Botsford ◽

Tamara L. Lenis ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Clinical Utility ◽

Clinical Decision Making ◽

Imaging System ◽

Imaging Modality ◽

Case Series ◽

Subretinal Fluid ◽

Optical Coherence ◽

Swept Source ◽

Oct Imaging

Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) imaging system. Methods: A retrospective, single-center, consecutive case series evaluated patients between September 2019 and October 2020 with UWF SS-OCT (modified Optos P200TxE, Optos PLC) as part of routine retinal care. The logistics of image acquisition, interpretability of images captured, nature of the peripheral abnormality, and clinical utility in management decisions were recorded. Results: Eighty-two eyes from 72 patients were included. Patients were aged 59.4 ± 17.1 years (range, 8-87 years). During imaging, 4.4 series of images were obtained in 4.1 minutes, with 86.4% of the image series deemed to be diagnostic of the peripheral pathology on blinded image review. The most common pathologic findings were chorioretinal scars (18 eyes). In 31 (38%) eyes, these images were meaningful in supporting clinical decision-making with definitive findings. Diagnoses imaged included retinal detachment combined with retinoschisis, retinal hole with overlying vitreous traction and subretinal fluid, vitreous inflammation overlying a peripheral scar, Coats disease, and peripheral retinal traction in sickle cell retinopathy. Conclusions: Navigated UWF SS-OCT imaging was clinically practical and provided high-quality characterization of peripheral retinal lesions for all eyes. Images directly contributed to management plans, including laser, injection or surgical treatment, for a clinically meaningful set of patients (38%). Future studies are needed to further assess the value of this imaging modality and its role in diagnosing, monitoring, and treating peripheral lesions.

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Synthetic polarization-sensitive optical coherence tomography by deep learning

npj Digital Medicine ◽

10.1038/s41746-021-00475-8 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Yi Sun ◽

Jianfeng Wang ◽

Jindou Shi ◽

Stephen A. Boppart

Keyword(s):

Optical Coherence Tomography ◽

Deep Learning ◽

Imaging System ◽

Imaging Modality ◽

Similarity Index ◽

Polarization Sensitivity ◽

Imaging Method ◽

Optical Coherence ◽

The Real ◽

Oct Imaging

AbstractPolarization-sensitive optical coherence tomography (PS-OCT) is a high-resolution label-free optical biomedical imaging modality that is sensitive to the microstructural architecture in tissue that gives rise to form birefringence, such as collagen or muscle fibers. To enable polarization sensitivity in an OCT system, however, requires additional hardware and complexity. We developed a deep-learning method to synthesize PS-OCT images by training a generative adversarial network (GAN) on OCT intensity and PS-OCT images. The synthesis accuracy was first evaluated by the structural similarity index (SSIM) between the synthetic and real PS-OCT images. Furthermore, the effectiveness of the computational PS-OCT images was validated by separately training two image classifiers using the real and synthetic PS-OCT images for cancer/normal classification. The similar classification results of the two trained classifiers demonstrate that the predicted PS-OCT images can be potentially used interchangeably in cancer diagnosis applications. In addition, we applied the trained GAN models on OCT images collected from a separate OCT imaging system, and the synthetic PS-OCT images correlate well with the real PS-OCT image collected from the same sample sites using the PS-OCT imaging system. This computational PS-OCT imaging method has the potential to reduce the cost, complexity, and need for hardware-based PS-OCT imaging systems.

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Rapid imaging of special nuclear materials for nuclear nonproliferation and terrorism prevention

Science Advances ◽

10.1126/sciadv.abg3032 ◽

2021 ◽

Vol 7 (21) ◽

pp. eabg3032

Author(s):

Jana Petrović ◽

Alf Göök ◽

Bo Cederwall

Keyword(s):

Nuclear Physics ◽

Imaging Modality ◽

Three Dimensional ◽

Nuclear Fission ◽

Machine Learning Techniques ◽

Nuclear Materials ◽

Prototype System ◽

Fast Time ◽

Gamma Emission ◽

Special Nuclear Materials

We introduce a neutron-gamma emission tomography (NGET) technique for rapid detection, three-dimensional imaging, and characterization of special nuclear materials like weapons-grade plutonium and uranium. The technique is adapted from fundamental nuclear physics research and represents a previously unexplored approach to the detection and imaging of small quantities of these materials. The method is demonstrated on a radiation portal monitor prototype system based on fast organic scintillators, measuring the characteristic fast time and energy correlations between particles emitted in nuclear fission processes. The use of these correlations in real time in conjunction with modern machine learning techniques provides unprecedented imaging efficiency and high spatial resolution. This imaging modality addresses global security threats from terrorism and the proliferation of nuclear weapons. It also provides enhanced capabilities for addressing different nuclear accident scenarios and for environmental radiological surveying.

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