scholarly journals Q Fever with Unusual Exposure History: A Classic Presentation of a Commonly Misdiagnosed Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Randall J. Nett ◽  
Earl Book ◽  
Alicia D. Anderson

We describe the case of a man presumptively diagnosed and treated for Rocky Mountain spotted fever following exposure to multiple ticks while riding horses. The laboratory testing of acute and convalescent serum specimens led to laboratory confirmation of acute Q fever as the etiology. This case represents a potential tickborne transmission ofCoxiella burnetiiand highlights the importance of considering Q fever as a possible diagnosis following tick exposures.

1943 ◽  
Vol 77 (4) ◽  
pp. 355-358 ◽  
Author(s):  
Harry Plotz ◽  
Joseph E. Smadel ◽  
Thomas F. Anderson ◽  
Leslie A. Chambers

The morphological structures of the rickettsiae of epidemic and endemic typhus fever, Rocky Mountain spotted fever, and Q fever are similar to one another and to certain bacteria. The rickettsial organisms in common with the elementary bodies of vaccinia virus and all bacteria would appear to have a limiting membrane which surrounds a substance that seems to be protoplasmic in nature; numbers of dense granules are embedded in the inner protoplasm.


PEDIATRICS ◽  
1958 ◽  
Vol 22 (2) ◽  
pp. 384-387
Author(s):  
Lauri Luoto

BECAUSE rickettsial infections occur sporadically, pediatricians may not be as thoroughly familiar with them as they are with common diseases of children that are characterized by rash. Hence, the rickettsias are infrequently considered in the etiology of febrile exanthemas or fevers of undertermined origin. Rickettsial diseases of primary interest in this country are Rocky Mountain spotted fever, murine typhus, rickcttsialpox and Q fever. The agents causing these diseases exist as latent infections in arthropods and animals, and they are transmitted accidentally to man through well-defined channels of spread. An awareness of the epizootiology of rickettsial diseases in nature and of the means by which these agents are transmitted to man is helpful in establishing a diagnosis of a rickettsial disease. Therefore, salient features of the natural cycles of infection which may suggest a clinical diagnosis will be stressed, and characteristics of these diseases in children will be reviewed briefly. Rocky Mountain spotted fever is usually contracted during the spring or summer through the bite of an infected tick although infection also may be acquired by dermal contact with tissues of a crushed or improperly removed tick. The wood tick, Dermacentor andersoni, the dog tick, D. variabilis, and the lone-star tick, Amblyomma americanum, which are found, respectively, in the western, eastern, and southern United States are responsible for transmitting the organism to man. Natural infection with Rickettsia rickettsii in these species is maintained by transovarial passage of the agent and by the feeding of immature stages on infected small mammals. Environmental factors such as rainfall, temperature, food supply of small mammals, and prevalence of predators indirectly affect the abundance of ticks.


2017 ◽  
Author(s):  
Lucas S Blanton

Infections caused by organisms of the genus Rickettsia, Orientia, Ehrlichia, Anaplasma, and Coxiella occur throughout the world and are important, yet often overlooked, causes of febrile illness. They are transmitted by ticks, lice, mites, fleas, and, in the case of Coxiella, infected aerosols. Some are considered emerging and reemerging infectious diseases, as exemplified by the emergence of Rocky Mountain spotted fever in the American Southwest and Mexico; the reemergence of murine typhus in parts of Texas; and the discovery of new pathogens, such as Ehrlichia muris–like agent. Manifestations are usually of an acute undifferentiated febrile illness, with associated headache, malaise, myalgias, and varying frequency of rash. Since confirmation of diagnosis is often retrospective, requiring the dynamic change in antibody titers from acute and convalescent phase sera, clinical recognition for empirical treatment is imperative. Indeed, timely treatment is effective at abating symptoms and preventing complications. This review discusses important aspects of the epidemiology, clinical manifestations, diagnostic methods, and treatment of infections caused by Rickettsia and related organisms.  This review contains 5 figures, 9 tables, and 50 references. Key words: anaplasmosis, ehrlichiosis, Q fever, Rocky Mountain spotted fever, scrub typhus, spotted fever group rickettsioses, typhus group rickettsioses


1956 ◽  
Vol 34 (5) ◽  
pp. 417-423 ◽  
Author(s):  
A. W. F. Banfield

A collection of 245 ticks (Dermacentor andersoni, Stiles, and Dermacentor albipictus, Packard) was made in the spring of 1953, from 17 localities in Banff National Park, Alberta. Laboratory tests indicated the presence of Colorado tick fever virus in three of 17 lots examined. One complement-fixation test was significantly positive for the Rocky Mountain spotted fever Rickettsia out of 19 tests. There was no indication of tularemia. One determination of the Q-fever virus was probably caused by laboratory contamination. The unfed adult ticks (D. andersoni) were found to be locally active from April 20 to June 22, 1953. The bighorn sheep (Ovis canadensis) was found to be the common local host of the adult tick. The Columbian ground squirrel (Citellus columbianus) was found to be the common host of the nymphs.


Author(s):  
Tatiana A. Chekanova ◽  
S. N. Shpynov ◽  
S. Zh. Netalieva ◽  
M. A. Babaeva

The article discusses the results of a retrospective study for the presence of Coxiellosis serological markers in 723 blood sera from 537 febrile patients hospitalized in May-September 2015 in the regional infectious hospital in the Astrakhan region. Blood sera were screened by ELISA for the presence of IgG and IgM to II phase Coxiella burnetii (IgG II and IgM II, respectively). Samples, containing IgG II, wear detected IgG to I phase C. burnetii (IgG I). 92 seropositive C. burnetii patients (including 15 children’s) were identified. Characteristics of the antibody profiles in this study (IgG II, IgG II + IgM II, IgG II + IgG I, IgG II + IgM II + IgG I, IgM II) and their titers were given. The clinical picture is typical for acute infectious diseases was more often noted (diagnoses - acute respiratory disease / acute respiratory viral infection, adenovirus infection, Astrakhan spotted fever, coxiellosis) at spectrum detecting IgM II, IgM II + IgG II or IgG II (1: 800-1: 1600 titters). The «unknown etiology viral infection» diagnosis was more common among adults with any possible antibodies spectrum. Diagnostic criteria of acute Q fever and chronic coxsiellosis are discussed in the context of the serological testing results.


Author(s):  
Tatiana A. Chekanova ◽  
S. N. Shpynov ◽  
S. Zh. Netalieva ◽  
M. A. Babaeva

The article discusses the results of a retrospective study for the presence of Coxiellosis serological markers in 723 blood sera from 537 febrile patients hospitalized in May-September 2015 in the regional infectious hospital in the Astrakhan region. Blood sera were screened by ELISA for the presence of IgG and IgM to II phase Coxiella burnetii (IgG II and IgM II, respectively). Samples, containing IgG II, wear detected IgG to I phase C. burnetii (IgG I). 92 seropositive C. burnetii patients (including 15 children’s) were identified. Characteristics of the antibody profiles in this study (IgG II, IgG II + IgM II, IgG II + IgG I, IgG II + IgM II + IgG I, IgM II) and their titers were given. The clinical picture is typical for acute infectious diseases was more often noted (diagnoses - acute respiratory disease / acute respiratory viral infection, adenovirus infection, Astrakhan spotted fever, coxiellosis) at spectrum detecting IgM II, IgM II + IgG II or IgG II (1: 800-1: 1600 titters). The «unknown etiology viral infection» diagnosis was more common among adults with any possible antibodies spectrum. Diagnostic criteria of acute Q fever and chronic coxsiellosis are discussed in the context of the serological testing results.


Author(s):  
Tom Fletcher ◽  
Nick Beeching

Rickettsial infections are caused by a variety of obligate intracellular, Gram-negative bacteria from the genera Rickettsia, Orientia, Ehrlichia, and Anaplasma. Rickettsia is further subdivided into the spotted fever group and the typhus group. Bartonella and Coxiella burnetii bacteria are similar to rickettsiae and cause similar diseases. The range of recognized spotted fever group infections is rapidly expanding, complementing long-recognized examples such as Rocky Mountain spotted fever (Rickettsia rickettsii) in the US, and Australian tick typhus (Rickettsia australis), as well as those in southern Europe and Africa. Animals are the predominant reservoir of infection, and transmission to people is usually through ticks, mites, fleas, or lice, during blood-feeding or from scarification of faeces deposited on the skin. This chapter focuses on the two of the most relevant infections encountered in UK practice: African tick typhus, and Q fever.


2005 ◽  
Vol 57 (3) ◽  
pp. 253-254 ◽  
Author(s):  
Dragana Rajkovic ◽  
A.D. Jurisic

As specific arthropods, ticks in urban environments transmit the agents of dangerous contagious diseases endangering human and animal health. They are vectors of numerous infective agents that cause serious diseases of animals such as babesiosis and ehrlichiosis. Tick populations maintain and transmit an increas?ing number of different infective agents. In regard to the human population, they transmit the agents of tick encephalitis, Omsk hemorrhagic disease, Crim-Congo hemorrhagic disease, Kyasa-nur forest fever, ixodid fever, Q fever, Rocky Mountain spotted fever, tularemia, Siberian tick typhus and Lyme disease the last of which according to acarological references has become the dominant zoonosis in over 140 of the world's countries. In urban environments ticks represent problem both for their epidemiological significance and as organisms whose presence disturbs people during their work and rest. In Europe, the two most fre?quent species and Ixodes ricinus and Ixodes persulcatus. Both species have a wide spectrum of hosts.


Praxis ◽  
2005 ◽  
Vol 94 (47) ◽  
pp. 1869-1870
Author(s):  
Balestra ◽  
Nüesch

Eine 37-jährige Patientin stellt sich nach der Rückkehr von einer Rundreise durch Nordamerika mit einem Status febrilis seit zehn Tagen und einem makulösem extremitätenbetontem Exanthem seit einem Tag vor. Bei suggestiver Klinik und Besuch der Rocky Mountains wird ein Rocky Mountain spotted fever diagnostiziert. Die Serologie für Rickettsia conorii, die mit Rickettsia rickettsii kreuzreagiert, war positiv und bestätigte die klinische Diagnose. Allerdings konnte der beweisende vierfache Titeranstieg, möglicherweise wegen spät abgenommener ersten Serologie, nicht nachgewiesen werden. Nach zweiwöchiger antibiotischer Therapie mit Doxycycline waren Status febrilis und Exanthem regredient.


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