scholarly journals DIAGNOSTIC SIGNIFICANCE OF ANTIBODIES SPECTRUM TO COXIELLA BURNETII IN I AND II PHASES

2018 ◽  
Vol 23 (4) ◽  
pp. 165-171
Author(s):  
Tatiana A. Chekanova ◽  
S. N. Shpynov ◽  
S. Zh. Netalieva ◽  
M. A. Babaeva
Keyword(s):  
Viral Infection ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Spotted Fever ◽  
Unknown Etiology ◽  
Serological Markers ◽  
Serological Testing ◽  
Diagnostic Significance ◽  
Acute Respiratory Viral Infection ◽  
Acute Q Fever

The article discusses the results of a retrospective study for the presence of Coxiellosis serological markers in 723 blood sera from 537 febrile patients hospitalized in May-September 2015 in the regional infectious hospital in the Astrakhan region. Blood sera were screened by ELISA for the presence of IgG and IgM to II phase Coxiella burnetii (IgG II and IgM II, respectively). Samples, containing IgG II, wear detected IgG to I phase C. burnetii (IgG I). 92 seropositive C. burnetii patients (including 15 children’s) were identified. Characteristics of the antibody profiles in this study (IgG II, IgG II + IgM II, IgG II + IgG I, IgG II + IgM II + IgG I, IgM II) and their titers were given. The clinical picture is typical for acute infectious diseases was more often noted (diagnoses - acute respiratory disease / acute respiratory viral infection, adenovirus infection, Astrakhan spotted fever, coxiellosis) at spectrum detecting IgM II, IgM II + IgG II or IgG II (1: 800-1: 1600 titters). The «unknown etiology viral infection» diagnosis was more common among adults with any possible antibodies spectrum. Diagnostic criteria of acute Q fever and chronic coxsiellosis are discussed in the context of the serological testing results.

scholarly journals DIAGNOSTIC SIGNIFICANCE OF ANTIBODIES SPECTRUM TO COXIELLA BURNETII IN I AND II PHASES

2018 ◽  
Vol 23 (4) ◽  
pp. 165-171
Author(s):  
Tatiana A. Chekanova ◽  
S. N. Shpynov ◽  
S. Zh. Netalieva ◽  
M. A. Babaeva
Keyword(s):  
Viral Infection ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Spotted Fever ◽  
Unknown Etiology ◽  
Serological Markers ◽  
Serological Testing ◽  
Diagnostic Significance ◽  
Acute Respiratory Viral Infection ◽  
Acute Q Fever

The article discusses the results of a retrospective study for the presence of Coxiellosis serological markers in 723 blood sera from 537 febrile patients hospitalized in May-September 2015 in the regional infectious hospital in the Astrakhan region. Blood sera were screened by ELISA for the presence of IgG and IgM to II phase Coxiella burnetii (IgG II and IgM II, respectively). Samples, containing IgG II, wear detected IgG to I phase C. burnetii (IgG I). 92 seropositive C. burnetii patients (including 15 children’s) were identified. Characteristics of the antibody profiles in this study (IgG II, IgG II + IgM II, IgG II + IgG I, IgG II + IgM II + IgG I, IgM II) and their titers were given. The clinical picture is typical for acute infectious diseases was more often noted (diagnoses - acute respiratory disease / acute respiratory viral infection, adenovirus infection, Astrakhan spotted fever, coxiellosis) at spectrum detecting IgM II, IgM II + IgG II or IgG II (1: 800-1: 1600 titters). The «unknown etiology viral infection» diagnosis was more common among adults with any possible antibodies spectrum. Diagnostic criteria of acute Q fever and chronic coxsiellosis are discussed in the context of the serological testing results.

scholarly journals Q Fever with Unusual Exposure History: A Classic Presentation of a Commonly Misdiagnosed Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Randall J. Nett ◽  
Earl Book ◽  
Alicia D. Anderson
Keyword(s):  
Coxiella Burnetii ◽  
Laboratory Testing ◽  
Q Fever ◽  
Spotted Fever ◽  
Rocky Mountain ◽  
Rocky Mountain Spotted Fever ◽  
Laboratory Confirmation ◽  
Exposure History ◽  
Acute Q Fever

We describe the case of a man presumptively diagnosed and treated for Rocky Mountain spotted fever following exposure to multiple ticks while riding horses. The laboratory testing of acute and convalescent serum specimens led to laboratory confirmation of acute Q fever as the etiology. This case represents a potential tickborne transmission ofCoxiella burnetiiand highlights the importance of considering Q fever as a possible diagnosis following tick exposures.

scholarly journals Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics

2009 ◽  
Vol 53 (6) ◽  
pp. 2690-2692 ◽  
Author(s):  
Ioanna Spyridaki ◽  
Anna Psaroulaki ◽  
Iosif Vranakis ◽  
Yannis Tselentis ◽  
Achilleas Gikas
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Vero Cells ◽  
In Vitro Susceptibility ◽  
Shell Vial ◽  
Bactericidal Activities ◽  
Acute Q Fever ◽  
Reference Strains ◽  
Shell Vial Assay

ABSTRACT The present article is a study of the in vitro susceptibility of eight Greek Coxiella burnetii isolates, derived from patients with acute Q fever, and two reference strains of Coxiella burnetii to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 μg/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 μg/ml; linezolid and clarithromycin ranged from 2 to 4 μg/ml; and ciprofloxacin ranged from 4 to 8 μg/ml. Tigecycline was effective in inhibiting the infection of Vero cells by C. burnetii. No bactericidal activity was observed against C. burnetii at 4 μg/ml.

scholarly journals Isolation of Coxiella burnetii from serum of patients with acute Q fever

2015 ◽  
Vol 119 ◽  
pp. 74-78 ◽  
Author(s):  
Gemma A. Vincent ◽  
Stephen R. Graves ◽  
Jennifer M. Robson ◽  
Chelsea Nguyen ◽  
Hazizul Hussain-Yusuf ◽  
...  
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Acute Q Fever

scholarly journals THE INFORMATIVE VALUE OF IMMUNOLOGICAL AND GENETIC TESTS IN THE DIAGNOSIS WEST NILE FEVER

2020 ◽  
Vol 76 (4) ◽  
pp. 42-45
Author(s):  
Т.V. Zamarina ◽  
◽  
N.P. Khrapova ◽  
I.A. Barkova ◽  
E.V. Pimenova ◽  
...  
Keyword(s):  
Viral Infection ◽  
Viral Rna ◽  
Unknown Etiology ◽  
West Nile Fever ◽  
West Nile ◽  
Respiratory Viral Infection ◽  
Blood Samples ◽  
Monitoring Centre ◽  
Laboratory Confirmation ◽  
Acute Respiratory Viral Infection

We used ELISA and PCR for laboratory verification of West Nile fever (MUC 4.2.3009-12). We analyzed serum and whole blood samples which had been sent to West Nile fever reference monitoring centre in 2018–2019. A total of 270 blood samples obtained from patients with presumed viral encephalitis of unknown etiology, acute respiratory viral infection, acute respiratory viral infection, meningitis, acute gastroenteritis were analyzed. Antibodies against WNV were detected in 193 (71,4 %) blood samples, while 146 samples were found to be capable of developing an immune response with viral RNA not being detected in them. Both WNV antibodies and viral RNA were detected in 47 (17,4 %) samples tested. WNV RNA was detected in only 14 (5,1 %) cases. Thus, laboratory confirmation of WNF was obtained in 76,6 % of cases (207 out of 270).

Acute Q fever in third trimester pregnancy

2021 ◽  
Vol 14 (8) ◽  
pp. e242558
Author(s):  
Maxwell Braddick ◽  
Marion L Woods ◽  
Suji Prabhaharan
Keyword(s):  
Back Pain ◽  
Coxiella Burnetii ◽  
Chronic Infection ◽  
Q Fever ◽  
Third Trimester ◽  
Blood Samples ◽  
Drug Intolerance ◽  
Trimester Pregnancy ◽  
Acute Q Fever ◽  
In Pregnancy

A 29-year-old gravida 2 para 1 woman presented at 29 weeks gestation with fevers, back pain, thrombocytopenia and hepatitis. PCR testing of blood samples detected Coxiella burnetii and paired serology later confirmed the diagnosis of acute Q fever in pregnancy. The patient was treated empirically with oral clarithromycin and experienced a symptomatic and biochemical improvement. Therapy was changed to oral trimethoprim/sulphamethoxazole but was complicated by a delayed cutaneous reaction, prompting recommencement of clarithromycin. Therapy continued until delivery of a healthy girl at 39 weeks and 3 days. Q fever in pregnancy is likely under-reported and is associated with the development of chronic infection and obstetric complications. Treatment with clarithromycin is an alternative to trimethoprim/sulphamethoxazole in the setting of drug intolerance.

scholarly journals Draft Genome Sequences of Three Coxiella burnetii Strains Isolated from Q Fever Patients

2017 ◽  
Vol 5 (38) ◽  
Author(s):  
Paul A. Beare ◽  
Brendan M. Jeffrey ◽  
Craig A. Martens ◽  
Robert A. Heinzen
Keyword(s):  
Coxiella Burnetii ◽  
Human Disease ◽  
Q Fever ◽  
Draft Genome ◽  
Genome Sequences ◽  
Content Type ◽  
Acute Q Fever

ABSTRACT In the current study, we determined the draft genome sequences of three Coxiella burnetii human disease isolates. The Coxiella burnetii Turkey (RSA315) and Dyer (RSA345) strains were isolated from acute Q fever patients, while the Ko (Q229) strain was isolated from a Q fever endocarditis patient.

Coxiella burnetii infections (Q fever)

2020 ◽  
pp. 1257-1262
Author(s):  
Thomas J. Marrie
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Mammary Glands ◽  
Serological Testing ◽  
Gram Negative ◽  
The Common ◽  
High Concentrations ◽  
Rats And Mice ◽  
Animal Reservoirs ◽  
Very High

Q fever is a zoonosis caused by Coxiella burnetii, an intracellular Gram-negative spore-forming bacterium, the common animal reservoirs of which are cattle, sheep, and goats. Rats and mice have been implicated as reservoirs in some areas. In French Guiana the three-toed sloth is the reservoir. C. burnetti is trophic for the endometrium and mammary glands of female animals, and during pregnancy the organism reaches very high concentrations in the placenta such that at the time of parturition organisms are aerosolized and contamination of the environment occurs. Inhalation of even one microorganism can result in infection. Diagnosis is confirmed by serological testing: in acute disease antibodies to phase II antigen are higher than those to phase I, whereas the reverse is true in chronic disease.

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