scholarly journals Lyme Disease and Oncothermia

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ortwin Zais
Keyword(s):  
Lyme Disease ◽  
Clinical Symptoms ◽  
Chronic Phase ◽  
Chronic Fatigue ◽  
Multiple Organ ◽  
Human Immune System ◽  
Fatigue Syndrome ◽  
Therapeutic Principles ◽  
Organ Failures ◽  
Tick Borne Disease

Lyme disease is a tick-borne disease with multiple organ failures, and systemic disorders. Dramatic change becomes apparent in the chronic phase of the disease. Chronic fatigue syndrome, lapse of concentration, depression, joint pain, and muscle pain are a few, but major clinical symptoms characterizing the disease. The human immune system is defenseless. Borrelia uses various mechanisms to escape from immunoattacks or antibiotic therapies. This “stealth phenomenon” needs new therapeutic principles to be interrupted. Our objective in this paper is to study the effect of oncothermia, which is a well-established oncological therapy, on Lyme disease. First, in our present work, we definitely concentrate on the quality of life of the patients.

scholarly journals Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic

mSphere ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Angela M. Thomm ◽  
Anna M. Schotthoefer ◽  
Alan P. Dupuis ◽  
Laura D. Kramer ◽  
Holly M. Frost ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Virus Infection ◽  
Clinical Symptoms ◽  
Diagnostic Testing ◽  
Chronic Fatigue ◽  
The United States ◽  
Full Spectrum ◽  
Persistent Symptoms ◽  
Powassan Virus ◽  
Tick Borne Disease

Approximately 100 cases of POWV disease were reported in the United States over the past 10 years. Most cases have occurred in the Northeast (52) and Great Lakes (45) regions (https://www.cdc.gov/powassan/statistics.html). The prevalence of POWV in ticks and mammals is increasing, and POWV poses an increasing threat in a greater geographical range. In areas of the Northeast and Midwest where Lyme disease is endemic, POWV testing is recommended for patients with a recent tick bite, patients with Lyme disease who have been treated with antibiotics, or patients with a tick exposure who have tested negative for Lyme disease or other tick-borne illnesses and have persistent symptoms consistent with posttreatment Lyme disease. Testing could also benefit patients with tick exposure and unexplained neurologic symptoms and chronic fatigue syndrome (CFS) patients with known tick exposure. Until now, diagnostic testing for Powassan virus has not been commercially available and has been limited to patients presenting with severe, neurologic complications. The lack of routine testing for Powassan virus in patients with suspected tick-borne disease means that little information is available regarding the overall prevalence of the virus and the full spectrum of clinical symptoms associated with infection. AsIxodes scapularisis the tick vector for Powassan virus and multiple other tick-borne pathogens, including the Lyme disease bacterium,Borrelia burgdorferi, the clinical presentations and long-term outcomes of Powassan virus infection and concurrent infection with other tick-borne disease pathogens remain unknown.

scholarly journals Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome

2019 ◽  
Vol 76 ◽  
pp. 82-96 ◽  
Author(s):  
Chinh Bkrong Nguyen ◽  
Surendra Kumar ◽  
Manuela Zucknick ◽  
Vessela N. Kristensen ◽  
Johannes Gjerstad ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Gene Networks ◽  
Clinical Symptoms ◽  
Chronic Fatigue ◽  
Plasma Norepinephrine ◽  
Immune Gene ◽  
Fatigue Syndrome

scholarly journals Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping

2021 ◽  
Vol 10 (18) ◽  
pp. 4171
Author(s):  
Jesús Castro-Marrero ◽  
Mario Zacares ◽  
Eloy Almenar-Pérez ◽  
José Alegre-Martín ◽  
Elisa Oltra
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Hierarchical Cluster ◽  
Chronic Fatigue ◽  
Blood Parameters ◽  
Myalgic Encephalomyelitis ◽  
Complement Factor ◽  
Fatigue Syndrome ◽  
Pain Symptoms ◽  
Rule Out

Background: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics only serve to rule out underlying conditions leading to exerting fatigue. However, studies evaluating complete and large blood datasets by combinatorial approaches to evidence ME/CFS condition or detect/identify case subgroups are still scarce. Methods: This study used unbiased hierarchical cluster analysis of a large cohort of 250 carefully phenotyped female ME/CFS cases toward exploring this possibility. Results: The results show three symptom-based clusters, classified as severe, moderate, and mild, presenting significant differences (p < 0.05) in five blood parameters. Unexpectedly the study also revealed high levels of circulating complement factor C1q in 107/250 (43%) of the participants, placing C1q as a key molecule to identify an ME/CFS subtype/subgroup with more apparent pain symptoms. Conclusions: The results obtained have important implications for the research of ME/CFS etiology and, most likely, for the implementation of future diagnosis methods and treatments of ME/CFS in the clinic.

scholarly journals Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption

2020 ◽  
Vol 9 (8) ◽  
pp. 2443 ◽  
Author(s):  
Markus Tölle ◽  
Helma Freitag ◽  
Michaela Antelmann ◽  
Jelka Hartwig ◽  
Mirjam Schuchardt ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Pilot Trial ◽  
Treatment Protocol ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Proof Of Concept ◽  
Rapid Improvement ◽  
Fatigue Syndrome

(1) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex neuroimmunological disease. There is evidence for an autoimmune mechanism for ME/CFS with an infection-triggered onset and dysfunction of ß2-adrenoreceptor antibodies (ß2AR-AB). In a first proof-of-concept study, we could show that IA was effective to reduce ß2AR-AB and led to improvement of various symptoms. (2) Five of the ME/CFS patients who had clinical improvement following treatment with a five-day IA were retreated in the current study about two years later with a modified IA protocol. The severity of symptoms was assessed by disease specific scores during a follow-up period of 12 months. The antibodies were determined by ELISA. (3) The modified IA treatment protocol resulted in a remarkable similar clinical response. The treatment was well tolerated and 80–90% decline of total IgG and ß2AR-AB was achieved. Four patients showed a rapid improvement in several clinical symptoms during IA therapy, lasting for six to 12 months. One patient had no improvement. (4) We could provide further evidence that IA has clinical efficacy in patients with ME/CFS. Data from our pilot trial warrant further controlled studies in ME/CFS.

scholarly journals Heterodox and Orthodox Discourses in the Case of Lyme Disease: A Synthesis of Arguments

2019 ◽  
Vol 29 (11) ◽  
pp. 1661-1673
Author(s):  
Kate Hinds ◽  
Katy Sutcliffe
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Lyme Disease ◽  
Critical Discourse Analysis ◽  
Chronic Fatigue ◽  
Critical Discourse ◽  
Fatigue Syndrome ◽  
Chronic Lyme Disease ◽  
Medically Unexplained ◽  
Patient Groups ◽  
Insight Into

In this article, we examine the arguments made by authors of published academic articles concerning the debates surrounding chronic Lyme disease (CLD). CLD is an example of a contested condition and shares problems of legitimacy with other medically unexplained conditions such as chronic fatigue syndrome. We use a critical discourse analysis (CDA) approach to understand the arguments of the authors to establish the legitimacy, or not, of a CLD diagnosis. This enabled us to make sense of the nature of the stalemate between patient groups and advocates of the medical establishment, as performed by authors of academic articles. In this article, we bring together the arguments to explain the polemical debate and to support accounts that avoid the impasse to give us greater insight into the experience of chronic illness.

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