scholarly journals Clinical Utility of Diffusion Tensor Imaging and Fibre Tractography for Evaluating Diffuse Axonal Injury with Hemiparesis

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ken Sugiyama ◽  
Takeo Kondo ◽  
Yoshimi Suzukamo ◽  
Yutaka Oouchida ◽  
Mari Sato ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Imaging Techniques ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Cerebral Peduncle ◽  
Motor Disorders ◽  
Healthy Controls ◽  
Left Hemiparesis ◽  
The Right

Although diffuse axonal injury (DAI) frequently manifests as cognitive and/or motor disorders, abnormal brain findings are generally undetected by conventional imaging techniques. Here we report the case of a patient with DAI and hemiparesis. Although conventional MRI revealed no abnormalities, diffusion tensor imaging (DTI) and fibre tractography (FT) revealed the lesion speculated to be responsible for hemiparesis. A 37-year-old woman fell down the stairs, sustaining a traumatic injury to the head. Subsequently, she presented with mild cognitive disorders and left hemiparesis. DTI fractional anisotropy revealed changes in the right cerebral peduncle, the right posterior limb of the internal capsule, and the right corona radiata when compared with the corresponding structures observed on the patient’s left side and in healthy controls. On FT evaluation, the right corticospinal tract (CST) was poorly visualised as compared with the left CST as well as the CST in healthy controls. These findings were considered as evidence that the patient’s left hemiparesis stemmed from DAI-induced axonal damage in the right CST. Thus, DTI and FT represent useful techniques for the evaluation of patients with DAI and motor disorders.

scholarly journals Detecting diffuse axonal injury in rat brainstems by diffusion tensor imaging and AQP4 expression

2015 ◽  
Vol 26 (s1) ◽  
pp. S1169-S1175
Author(s):  
Wenbin Zheng ◽  
Chunlin Ma ◽  
Lingmei Kong ◽  
Xiran Chen ◽  
Wenyao Fan
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Aqp4 Expression

Clinical Utility of Diffusion Tensor Imaging for Evaluating Patients with Diffuse Axonal Injury and Cognitive Disorders in the Chronic Stage

2009 ◽  
Vol 26 (11) ◽  
pp. 1879-1890 ◽  
Author(s):  
Ken Sugiyama ◽  
Takeo Kondo ◽  
Yutaka Oouchida ◽  
Yoshimi Suzukamo ◽  
Shuichi Higano ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Clinical Utility ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Cognitive Disorders ◽  
Chronic Stage

Analysis of Diffuse Axonal Injury Using Diffusion Tensor Imaging in Traumatic Brain Injury Patients

2010 ◽  
Vol 3 (2) ◽  
pp. 111
Author(s):  
Hyung Jong Choi ◽  
Jong-Gu Kang ◽  
Seung Ho Ahn ◽  
Suk Hoon Ohn ◽  
Kwang-Ik Jung ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

scholarly journals A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia

2007 ◽  
Vol 38 (6) ◽  
pp. 877-885 ◽  
Author(s):  
V. Cheung ◽  
C. Cheung ◽  
G. M. McAlonan ◽  
Y. Deng ◽  
J. G. Wong ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Structural Connectivity ◽  
First Episode ◽  
Cerebral Peduncle ◽  
Healthy Controls ◽  
Subcortical Region ◽  
First Episode Schizophrenia

BackgroundDiffusion tensor imaging (DTI) can be used to investigate cerebral structural connectivity in never-medicated individuals with first-episode schizophrenia.MethodSubjects with first-episode schizophrenia according to DSM-IV-R who had never been exposed to antipsychotic medication (n=25) and healthy controls (n=26) were recruited. Groups were matched for age, gender, best parental socio-economic status and ethnicity. All subjects underwent DTI and structural magnetic resonance imaging (MRI) scans. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values differed significantly between groups. A confirmatory region-of-interest (ROI) analysis of FA scores was performed in which regions were placed blind to group membership.ResultsIn patients, FA values significantly lower than those in healthy controls were located in the left fronto-occipital fasciculus, left inferior longitudinal fasciculus, white matter adjacent to right precuneus, splenium of corpus callosum, right posterior limb of internal capsule, white matter adjacent to right substantia nigra, and left cerebral peduncle. ROI analysis of the corpus callosum confirmed that the patient group had significantly lower mean FA values than the controls in the splenium but not in the genu. The intra-class correlation coefficient (ICC) for independent ROI measurements was 0.90 (genu) and 0.90 (splenium). There were no regions where FA values were significantly higher in the patients than in the healthy controls.ConclusionsWidespread structural dysconnectivity, including the subcortical region, is already present in neuroleptic-naive patients in their first episode of illness.

Diffusion tensor imaging fiber tractography for evaluating diffuse axonal injury

Brain Injury ◽  
2007 ◽  
Vol 21 (4) ◽  
pp. 413-419 ◽  
Author(s):  
Ken Sugiyama ◽  
Takeo Kondo ◽  
Shuichi Higano ◽  
Minoru Endo ◽  
Hiroshi Watanabe ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Fiber Tractography

Application of Diffusion Tensor Imaging in Modeling Diffuse Axonal Injury

2009 ◽  
Author(s):  
Rika M. Wright ◽  
K. T. Ramesh
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Fiber Orientation ◽  
Structural Damage ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Material Model ◽  
Orientation Data ◽  
The Brain

Traumatic brain injury (TBI) is a debilitating injury that has received a lot of attention within the past few years partly as a result of the increased number of TBI incidents arising from military conflicts. Of the incidences of TBI, diffuse axonal injury (DAI) accounts for the second largest percentage of deaths [1]. DAI is caused by sudden inertial loads to the head, and it is characterized by damage to neural cells [2]. These inertial loads at the macroscale result in functional and structural damage at the cellular level. To understand the coupling between the mechanical forces and the functional damage of neurons, an analytical model that accurately represents the mechanics of brain deformation under inertial loads must be developed. It has been shown in clinical and experimental studies that the deep white matter of the brain is highly susceptible to injury [2]. Unlike the gray matter of the brain, the white matter structures contain an organized arrangement of neural axons and therefore can be considered anisotropic (Figure 1). To account for the anisotropic nature of the white matter in finite element simulations, the orientation of the neural axons must be incorporated into a material model for brain tissue. In this study, the use of diffusion tensor imaging (DTI) as a tool to provide fiber orientation information to continuum models is investigated. By incorporating fiber orientation data into a material model for white matter, the strains experienced by neural axons in the white matter tracts of the brain are computed, and this strain is related to cellular stretch thresholds of diffuse axonal injury.

Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury

Brain Injury ◽  
2011 ◽  
Vol 25 (4) ◽  
pp. 370-378 ◽  
Author(s):  
Johan Ljungqvist ◽  
Daniel Nilsson ◽  
Maria Ljungberg ◽  
Ann Sörbo ◽  
Eva Esbjörnsson ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Longitudinal Study ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Imaging Properties
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