scholarly journals Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
V. A. Korzhikov ◽  
K. V. Gusevskaya ◽  
E. N. Litvinchuk ◽  
E. G. Vlakh ◽  
T. B. Tennikova
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Phase Separation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biodegradable Polymer ◽  
Ring Opening ◽  
Monomer Concentration ◽  
Ring Opening Polymerization ◽  
Enzyme Ratio

The optimization of enzyme-mediated polymerization of pentadecalactone (PDL) was performed to obtain macromolecular products suitable for generation of 3D cell supports (scaffolds) for bone tissue engineering. Such parameters as temperature, monomer/enzyme ratio, and monomer concentration were studied. The maximum molecular weight of synthesized polymers was about 90,000. Methods allowing the introduction of reactive double bonds into polypentadecalactone (polyPDL) structure were developed. The macroporous matrices were obtained by modification of thermoinduced phase separation method.

Preparation and characterization of foamy poly(γ-benzyl-l-glutamate-co-l-phenylalanine)/bioglass composite scaffolds for bone tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (77) ◽  
pp. 73699-73708 ◽  
Author(s):  
Ning Cui ◽  
Junmin Qian ◽  
Jinlei Wang ◽  
Chuanlei Ji ◽  
Weijun Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Amino Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Composite Scaffolds ◽  
Templating Method

Novel foamy scaffolds of poly(γ-benzyl-l-glutamate) and poly(γ-benzyl-l-glutamate-co-l-phenylalanine) were fabricated via a combination of a sintered NaCl templating method and ring-opening polymerization of α-amino acid N-carboxyanhydrides.

Bio-safe fabrication of PLA scaffolds for bone tissue engineering by combining phase separation, porogen leaching and scCO2 drying

2015 ◽  
Vol 97 ◽  
pp. 238-246 ◽  
Author(s):  
Aurelio Salerno ◽  
Mar Fernández-Gutiérrez ◽  
Julio San Román del Barrio ◽  
Concepción Domingo
Keyword(s):  
Tissue Engineering ◽  
Phase Separation ◽  
Bone Tissue Engineering ◽  
Bone Tissue

Preparation of PLLA/HAP/β-TCP Composite Scaffold for Bone Tissue Engineering

2014 ◽  
Vol 513-517 ◽  
pp. 143-146 ◽  
Author(s):  
Xue Jun Wang ◽  
Tao Lou ◽  
Jing Yang ◽  
Zhen Yang ◽  
Kun Peng He
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Lactic Acid ◽  
Phase Separation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Thermally Induced Phase Separation ◽  
Composite Scaffolds ◽  
Thermally Induced

In this study, a nanofibrous poly (L-lactic acid) (PLLA) scaffold reinforced by Hydroxyapatite (HAP) and β-tricalcium phosphate (β-TCP) was fabricated using the thermally induced phase separation method. The composite scaffold morphology showed a nanofibrous PLLA matrix and evenly distributed β-TCP/HAP particles. The composite scaffold had interconnective micropores and the pore size ranged 2-10 μm. Introducing β-TCP/HAP particles into PLLA matrix significantly improved the mechanical properties of the composite scaffold. In summary, the new composite scaffolds show a great deal promise for use in bone tissue engineering.

Lipase-catalyzed synthesis of aliphatic polyesters in supercritical carbon dioxide

e-Polymers ◽  
2001 ◽  
Vol 1 (1) ◽  
Author(s):  
Tetsufumi Takamoto ◽  
Hiroshi Uyama ◽  
Shiro Kobayashi
Keyword(s):  
Carbon Dioxide ◽  
Molecular Weight ◽  
Supercritical Carbon Dioxide ◽  
Ring Opening ◽  
Monomer Concentration ◽  
Random Copolymer ◽  
Ring Opening Polymerization ◽  
Reaction Parameters ◽  
Aliphatic Polyesters ◽  
Supercritical Carbon

AbstractSynthesis of aliphatic polyesters has been examined using Candidaantarctica lipase in supercritical carbon dioxide (scCO2). The enzymatic ring-opening polymerization of ε-caprolactone (ε-CL) proceeded in scCO2 to give a polymer with molecular weight higher than 104. Effects of reaction parameters such as the monomer concentration, enzyme amount and pressure have been systematically investigated. Copolymerization of ε-CL with 12-docecanolide afforded the random copolymer. The enzymatic polycondensation of divinyl adipate and 1,4-butanediol also proceeded in scCO2 to produce the corresponding polyester.

scholarly journals Effect on electrospun fibres by synthesis of high branching polylactic acid

2018 ◽  
Vol 5 (9) ◽  
pp. 180134 ◽  
Author(s):  
Wen Shen ◽  
Guanghua Zhang ◽  
Xuemei Ge ◽  
Yali Li ◽  
Guodong Fan
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Tissue Engineering Scaffolds ◽  
Polar Property ◽  
Strong Adsorption ◽  
Potential Applications ◽  
Ultra High Molecular Weight ◽  
Fibre Preparation

Polylactic electrospun porous fibres have been widely used in tissue engineering scaffolds. However, the application of linear polylactic is limited due to its poor hydrophilicity, which leads to phase separation and has been seldom used in porous fibre preparation. Instead, branching polylactic acts as a new effective method to prepare porous fibres because it can increase polylactic polar property and make it easy to be formulated in the following application. In the current study, we prepared an ultra-high molecular weight of high branching polylactic with glycerol as the initiator by controlling the ring-opening polymerization time, adding amount of catalyst and glycerol. The structure, molecular weight and thermal properties of copolymers were tested subsequently. The result showed that the surface of the high branching polylactic films is smooth, hydrophilic and porous. This branching polylactic formed electrospun porous fibres and possessed a strong adsorption of silver ion. Our study provided a simple and efficient way to synthesize branching polylactic polymer and prepare electrospun porous fibres, which may provide potential applications in the field of biomaterials for tissue engineering or antibacterial dressing compared with the application of linear polylactic and 3-arm polylactic materials.

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