IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers

Objectives. To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers.Design and Methods. We treated 48 consecutive patients with diabetic foot ulcers with HBOT. Alterations of IGF-1 levels in patients whose wound healed with HBOT were compared with those in patients who did not benefit from HBOT.Results. There was no significant difference in initial IGF-1 levels between the two groups(P=0.399). The mean IGF-1 level increased with HBOT(P<0.05). In the healed group, the mean IGF-1 increase and the final values were significantly higher(P<0.05). In the nonhealed group, the mean IGF-1 increase was minus and the final values were not significantly different(P<0.05). The increase in IGF-1 level with HBOT was significantly higher in the healed group(P<0.001).Conclusions. IGF-1 increased significantly in the healed group. We believe that HBOT is effective in the treatment of diabetic foot ulcers, with an elevation of IGF-1. This alteration seems to be a predictive factor for wound healing in diabetic foot ulcers treated with HBOT.

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Effect of Hemoglobin A1C on Wound Healing in Diabetic Foot Ulcers Treated with Hyperbaric Oxygen Therapy

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2019.08.213 ◽

2019 ◽

Vol 229 (4) ◽

pp. S93-S94

Author(s):

Sharmeen Husain ◽

Sami Shoucair ◽

David Blitzer ◽

David Z. Martin

Keyword(s):

Wound Healing ◽

Hyperbaric Oxygen ◽

Diabetic Foot ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Hemoglobin A1c ◽

Foot Ulcers ◽

Diabetic Foot Ulcers

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Role of hyperbaric oxygen therapy in the treatment of chronic ulcers of the foot in patients with type II diabetes mellitus

International Surgery Journal ◽

10.18203/2349-2902.isj20194398 ◽

2019 ◽

Vol 6 (10) ◽

pp. 3492

Author(s):

Said El Mallah ◽

Abd El Moniem Fareed ◽

Omar M. Abd Al-Halim Ghaly

Keyword(s):

Hyperbaric Oxygen ◽

Diabetic Foot ◽

Hyperbaric Oxygen Therapy ◽

Type Ii Diabetes ◽

Oxygen Therapy ◽

Foot Ulcers ◽

Diabetic Patients ◽

Type Ii ◽

Diabetic Foot Ulcers ◽

Significant Difference

Background: The aim of this study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) in healing of chronic foot ulcers in patients with type II diabetes mellitus.Methods: A case control study included 40 type II diabetic patients with chronic foot ulcers not healing for more than 4 weeks. It has been conducted at Naser Institute for Research and Treatment and Menoufia University Hospital during the period between April 2017 and September 2018. Patients with non-healing diabetic foot ulcers were referred by physicians and were also identified through a number of wound care clinics in various hospitals.Results: Most ulcers were observed in the sole and heel in both groups A and B (n=14 and 9 respectively), while the rest of ulcers were distributed in other areas of the foot, namely the medial and lateral malleoli, dorsum and toes. On comparing the wound related complications developing during the treatment period, no statistically significant difference was found between both groups (p=0.147). As regards Wagner's grade, 7 patients (17.5%) had grade 4 ulcers, 18 patients (45%) had grade 3 ulcers and 15 patients (37.5%) had grade 2 ulcers, showing no statistically significant difference between both groups before treatment (p=0.259).Conclusions: HBOT is a useful adjunct in the treatment of non-healing diabetic foot ulcers, and that the cost of HBOT itself will be reduced as it becomes more widely available in the clinical setting, and as further knowledge of its other advantages, such as limited side effects and relative safety, become more widely appreciated.

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