scholarly journals Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ivan B. Jovanović ◽  
Miljan Veličković ◽  
Dragan Vuković ◽  
Svetlana Milanović ◽  
Olivera Valčić ◽  
...  
Keyword(s):  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Prostaglandin F2α ◽  
Glutathione Peroxidase Activity ◽  
Retained Placenta ◽  
Significant Difference ◽  
Prostaglandin F ◽  
Group A ◽  
Group B

The incidence of retained placenta (RP) in cows increases in cases of parturition induced by prostaglandin F2α. We analyzed the effects of different doses of supplemental selenium and vitamin E on the incidence of RP, blood selenium, plasma thyronines, and malondialdehyde concentration. Thirty-three clinically healthy, multiparous Holstein-Frisian cows were assigned to 3 groups and supplemented with a single intramuscular injection of sodium selenite (SS) and tocopherol acetate (TAc) between days 250 to 255 of gestation: control—unsupplemented; group A—10 mg SS + 400 mg TAc; group B—20 mg SS + 800 mg TAc. Parturition was induced using PGF2α not before day 275 of gestation. The RP incidence was reduced from 66.7% in the control to 38.2 and 30.8% in groups A and B, respectively. Blood selenium and glutathione peroxidase activity in treated groups were significantly higher compared to control, with no significant difference between groups A and B. Plasma malondialdehyde in group B was significantly lower than that in control and group A, while thyronines levels were not affected. Comparison of RP and non-RP cows, independently of supplement treatment, revealed higher blood selenium and glutathione peroxidase activity and lower MDA and thyroxine in non-RP animals, while triiodothyronine level did not differ.

scholarly journals Abnormal antioxidant defence in some tissues of congenitally obese mice

1984 ◽  
Vol 219 (1) ◽  
pp. 41-49 ◽  
Author(s):  
I D Capel ◽  
H M Dorrell
Keyword(s):  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Cumene Hydroperoxide ◽  
Hepatic Tissue ◽  
Obese Mice ◽  
Glutathione Peroxidase Activity ◽  
Antioxidant Defence ◽  
Reactive Material ◽  
Antioxidant Defence System ◽  
Significant Difference

The concentration of lipoperoxides (estimated as thiobarbituric acid-reactive material) and some components of the antioxidant defence system have been compared in various tissues of lean and congenitally obese mice. NADPH-stimulated lipoperoxide generation in vitro was significantly higher in microsomes (microsomal fractions) prepared from obese hepatic tissue than lean. Plasma, liver and brain lipoperoxide concentration was significantly higher in obese mice. In blood derived from obese mice the concentration of non-enzymic antioxidants including caeruloplasmin and vitamin A was higher, but hepatic retinol concentration was lower in these animals. In all the tissues assayed the glutathione peroxidase activity against H2O2 was less than its activity against cumene hydroperoxide. Assayed with either substrate, glutathione peroxidase activity was significantly higher in the brain and blood of obese mice than their lean counterparts. Conversely, liver glutathione peroxidase was decreased in obese animals, representing 43% of the activity of the lean-mouse liver enzyme against H2O2 and 81% of the cumene hydroperoxide-reducing activity. The liver of obese mice had significantly less, and the kidneys more, oxidized glutathione than the corresponding tissues of lean mice. Further investigations on hepatic tissue indicated that glutathione reductase activity was lower in the obese animals, but there was no significant difference between glucose-6-phosphate dehydrogenase activity in obese and lean mice.

scholarly journals Effect of vitamin E (DL-all-rac-a-tocopherol acetate) and nano particles of selenium on growth, survival, body composition and whole body glutathione peroxidase (GPX) and malondialdehyde (MDA) in Rutilus kutum (Kamensky, 1901)

2017 ◽  
Vol 19 (2) ◽  
pp. 69-76
Author(s):  
Davoud Tahmasbi ◽  
Saeid Gorgin ◽  
Mohammad Mazendarani ◽  
Mohammad Sudagar
Keyword(s):  
Body Composition ◽  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Carcass Composition ◽  
Nano Particles ◽  
Whole Body ◽  
Glutathione Peroxidase Activity ◽  
Tocopherol Acetate ◽  
Malondialdehyde Content

Abstract The effect of vitamin E (100 mg kg−1) and nano-selenium (1 mg kg−1), which have a nutritional relationship separately and in combination, was investigated on growth, survival, carcass composition, body glutathione peroxidase activity, and body malondialdehyde content of Rutilus kutum. Results showed that vitamin E is capable of improving growth, FCR and WG in Kutum fingerlings; however, nano-selenium is not. According to this study, vitamin E can improve growth and selenium can improve glutathione peroxidase activity in Rutilus kutum larvae.

0818 Effect of selenium and vitamin E supplementation on blood glutathione peroxidase activity and selenium in moderately exercised horses

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 393-394
Author(s):  
E. Velázquez Cantón ◽  
A. H. Ramírez Pérez ◽  
L. A. Zarco Quintero ◽  
R. Rosiles Martínez ◽  
J. C. Ángeles Hernández
Keyword(s):  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Glutathione Peroxidase Activity ◽  
Vitamin E Supplementation

Vitamin E protection of obesity-enhanced vascular calcification in uremic rats

2014 ◽  
Vol 306 (4) ◽  
pp. F422-F429 ◽  
Author(s):  
A. Peralta-Ramírez ◽  
A. Montes de Oca ◽  
A. I. Raya ◽  
C. Pineda ◽  
I. López ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Calcium Concentration ◽  
Soft Tissues ◽  
Zucker Rats ◽  
Glutathione Peroxidase Activity ◽  
Obese Rats

This study aimed to determine the extent of extraskeletal calcification in uremic Zucker rats, by comparing obese and lean phenotypes, and to evaluate the influence of vitamin E (VitE) on the development of calcifications in both uremic rats and human vascular smooth muscle cells (HVSMCs) cultured in vitro. Zucker rats of lean and obese phenotypes with normal renal function [control (C); C-lean and C-obese groups] and with uremia [5/6 nephrectomy (Nx); Nx-lean and Nx-obese groups] and uremic rats treated with VitE (Nx-lean + VitE and Nx-obese + VitE groups) were studied. Uremic groups were subjected to Nx, fed a 0.9% phosphorus diet, and treated with calcitriol (80 ng/kg ip). The aortic calcium concentration was significantly higher ( P < 0.05) in Nx-obese rats (10.0 ± 2.1 mg/g tissue) than in Nx-lean rats (3.6 ± 1.3 mg/g tissue). A decrease in plasma glutathione peroxidase activity was observed in Nx-obese rats compared with Nx-lean rats (217.2 ± 18.2 vs. 382.3 ± 15.5 nmol·min−1·ml−1, P < 0.05). Treatment with VitE restored glutathione peroxidase activity and reduced the aortic calcium concentration to 4.6 ± 1.3 mg/g tissue. The differences in mineral deposition between Nx-lean, Nx-obese, Nx-lean + VitE, and Nx-obese + VitE rats were also evidenced in other soft tissues. In HVSMCs incubated with high phosphate, VitE also prevented oxidative stress and reduced calcium content, bone alkaline phosphatase, and gene expression of core-binding factor-α1. In conclusion, uremic obese rats develop more severe calcifications than uremic lean rats and VitE reduces oxidative stress and vascular calcifications in both rats and cultures of HVSMCs.

Sign in / Sign up

Export Citation Format

Share Document