scholarly journals Involvement of miRNAs in Placental Alterations Mediated by Oxidative Stress

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Alexander Rudov ◽  
Walter Balduini ◽  
Silvia Carloni ◽  
Serafina Perrone ◽  
Giuseppe Buonocore ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Pregnancy Loss ◽  
Direct Link ◽  
Intrauterine Growth ◽  
Diagnosis And Prognosis ◽  
Pathological Conditions ◽  
Growing Body

Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, preterm labor, and intrauterine growth restriction. While a considerable number of miRNAs have been related to physiological functions and pathological conditions of the placenta, a direct link among these miRNAs, placental functions, and OS is still lacking. This review summarizes data describing the role of miRNAs in placental pathophysiological processes and their possible impact on OS damaging responses. As miRNAs can be found in circulation, improving our understanding on their role in the pathogenesis of pregnancy related disorders could have an important impact on the diagnosis and prognosis of these diseases.

scholarly journals Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes

Physiology ◽  
2018 ◽  
Vol 33 (5) ◽  
pp. 348-359 ◽  
Author(s):  
Cetewayo S. Rashid ◽  
Amita Bansal ◽  
Rebecca A. Simmons
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Intrauterine Growth Restriction ◽  
Metabolic Diseases ◽  
Growth Restriction ◽  
Mitochondria Dysfunction ◽  
Intrauterine Growth ◽  
And Oxidative Stress

Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.

Role of oxidative stress in preeclampsia and intrauterine growth restriction

2012 ◽  
Vol 38 (4) ◽  
pp. 658-664 ◽  
Author(s):  
Ismail Mert ◽  
Ayla Sargın Oruc ◽  
Serdar Yuksel ◽  
Esra Sukran Cakar ◽  
Umran Buyukkagnıcı ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals The physiologic and therapeutic role of Heparin in implantation and placentation

2014 ◽  
Author(s):  
Michela Quaranta ◽  
Offer Erez ◽  
Salvatore Andrea Mastrolia ◽  
Arie Koifman ◽  
Elad Leron ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Normal Pregnancy ◽  
Fetal Demise ◽  
Therapeutic Role ◽  
Intrauterine Growth ◽  
Treatment And Prevention ◽  
Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

Role of Oxidative Stress in Intrauterine Growth Restriction

2007 ◽  
Vol 64 (4) ◽  
pp. 187-192 ◽  
Author(s):  
Aydan Biri ◽  
Nuray Bozkurt ◽  
Ahmet Turp ◽  
Mustafa Kavutcu ◽  
Özdemir Himmetoglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Influence of Aerobic Training on the Reduced Vasoconstriction to Angiotensin II in Rats Exposed to Intrauterine Growth Restriction: Possible Role of Oxidative Stress and AT2 Receptor of Angiotensin II

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113035 ◽  
Author(s):  
Vanessa Oliveira ◽  
Eliana Hiromi Akamine ◽  
Maria Helena C. Carvalho ◽  
Lisete Compagno Michelini ◽  
Zuleica Bruno Fortes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Intrauterine Growth Restriction ◽  
Aerobic Training ◽  
Growth Restriction ◽  
At2 Receptor ◽  
Intrauterine Growth

Pregnancy loss and antiphospholipid antibodies

Lupus ◽  
1998 ◽  
Vol 7 (2_suppl) ◽  
pp. 86-89 ◽  
Author(s):  
M D Lockshin
Keyword(s):  
Intrauterine Growth Restriction ◽  
Pregnancy Loss ◽  
Fetal Loss ◽  
Critical Event ◽  
Intrauterine Growth ◽  
Fetal Survival ◽  
Low Dose Heparin ◽  
Repeated Pregnancy Loss

With the use of low-dose heparin, fetal survival of aPL pregnancies is 70-80%, but prematurity and intrauterine growth restriction are common. It is likely, but not proven, that dysregulated placental coagulation and resultant vasculopathy are the cause of fetal loss. Details of dysregulated coagulation remain to be described. Opportunities remain to determine the role of coagulopathy in repeated pregnancy loss, identify a critical event or window to which intervention might be directed, identify maternal (and fetal) characteristics other than aPL that determine fetal loss, describe toxicity profiles of current treatments, develop more specific, less toxic therapies, and describe long-term fetal and maternal outcomes.

scholarly journals The physiologic and therapeutic role of Heparin in implantation and placentation

2014 ◽  
Author(s):  
Michela Quaranta ◽  
Offer Erez ◽  
Salvatore Andrea Mastrolia ◽  
Arie Koifman ◽  
Elad Leron ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Normal Pregnancy ◽  
Fetal Demise ◽  
Therapeutic Role ◽  
Intrauterine Growth ◽  
Treatment And Prevention ◽  
Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

scholarly journals New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics

2021 ◽  
Vol 11 (3) ◽  
pp. 219
Author(s):  
Ya-Ling Yang ◽  
Yen-Hsiang Chang ◽  
Chia-Jung Li ◽  
Ying-Hsien Huang ◽  
Ming-Chao Tsai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Microenvironment ◽  
Crucial Role ◽  
Human Cancer ◽  
Metabolic Adaptation ◽  
Advanced Hcc ◽  
Diagnosis And Prognosis ◽  
Competitive Endogenous Rnas ◽  
Growing Body

Hepatocellular carcinoma (HCC) remains one of the most lethal human cancer globally. For advanced HCC, curable plan for advanced HCC is yet to be established, and the prognosis remains poor. The detail mechanisms underlying the progression of HCC tumorigenicity and the corruption of tumor microenvironment (TME) is complex and inconclusive. A growing body of studies demonstrate microRNAs (miRs) are important regulators in the tumorigenicity and TME development. Notably, mounting evidences indicate miR-29a play a crucial role in exerting hepatoprotective effect on various types of stress and involved in the progression of HCC, which elucidates their potential theragnostic implications. In this review, we reviewed the advanced insights into the detail mechanisms by which miR-29a dictates carcinogenesis, epigenetic program, and metabolic adaptation, and implicated in the sponging activity of competitive endogenous RNAs (ceRNA) and the TME components in the scenario of HCC. Furthermore, we highlighted its clinical significance in diagnosis and prognosis, as well as the emerging therapeutics centered on the activation of miR-29a.

The Role of the Anti-Angiogenic Factor Endostatin in Intrauterine Growth Restriction

2005 ◽  
Vol 12 (3) ◽  
pp. 195-197 ◽  
Author(s):  
Ariadne Malamitsi-Puchner ◽  
Theodora Boutsikou ◽  
Emmanuel Economou ◽  
Evangelos Makrakis ◽  
Zoe Iliodromiti ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Angiogenic Factor ◽  
Intrauterine Growth
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