scholarly journals Female Asthma Has a Negative Effect on Fertility: What Is the Connection?

ISRN Allergy ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Elisabeth Juul Gade ◽  
Simon Francis Thomsen ◽  
Svend Lindenberg ◽  
Vibeke Backer
Keyword(s):  
Systemic Inflammation ◽  
Pregnancy Outcomes ◽  
Time To Pregnancy ◽  
Vitro Fertilization ◽  
Future Studies ◽  
Biological Children ◽  
Negative Effect ◽  
Optimal Target ◽  
Adverse Pregnancy

Reproductive changes such as impaired fertility and adverse pregnancy outcomes have been related to female asthma. We recently found that time to pregnancy is prolonged in asthmatic females especially in women with moderate to severe asthma and in those above 30 years of age. Despite their reproductive difficulties the asthmatics ultimately conceived just as many biological children as healthy throughout their reproductive lives. This knowledge therefore raises questions about how asthma affects fertility pathophysiologically. The purpose of this review is to describe the existing knowledge in this field and suggest hypotheses of causal relationships, which may form the basis for future studies in this field. The aim is, in particular, in the literature to examine whether there is any evidence to suggest that the systemic inflammation that characterizes asthma, can affect fertility. The issue is potentially clinically important for asthmatic, infertile individuals and society because treatment of the general systemic inflammation associated with the asthmatic disease combined with hormone stimulation might be the optimal target for an effective infertility therapy, possibly decreasing the need for in vitro fertilization.

scholarly journals Adverse pregnancy outcomes after in vitro fertilization: effect of number of embryos transferred and plurality at conception

2015 ◽  
Vol 104 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Barbara Luke ◽  
Judy E. Stern ◽  
Milton Kotelchuck ◽  
Eugene R. Declercq ◽  
Mark D. Hornstein ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Vitro Fertilization ◽  
Fertilization Effect ◽  
Adverse Pregnancy

1019 Twin gestations conceived via in vitro fertilization are associated with increased adverse pregnancy outcomes

2021 ◽  
Vol 224 (2) ◽  
pp. S631
Author(s):  
Moti Gulersen ◽  
Yael Eliner ◽  
Amos Grunebaum ◽  
Erez Lenchner ◽  
Liron Bar-El ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Vitro Fertilization ◽  
Adverse Pregnancy

scholarly journals Differences in First-Trimester Maternal Metabolomic Profiles in Pregnancies Conceived From Fertility Treatments

2018 ◽  
Vol 104 (4) ◽  
pp. 1005-1019 ◽  
Author(s):  
Tianyanxin Sun ◽  
Bora Lee ◽  
Jason Kinchen ◽  
Erica T Wang ◽  
Tania L Gonzalez ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcomes ◽  
First Trimester ◽  
Maternal Plasma ◽  
Adverse Outcomes ◽  
Hormone Production ◽  
Vitro Fertilization ◽  
Fertility Treatments ◽  
Adverse Pregnancy

Abstract Context Maternal metabolic status reflects underlying physiological changes in the maternal-placental-fetal unit that may help identify contributors to adverse pregnancy outcomes associated with infertility and treatments used. Objective To determine if maternal metabolomic profiles differ between spontaneous pregnancies and pregnancies conceived with fertility treatments that may explain the differences in pregnancy outcomes. Design Metabolon metabolomic analysis and ELISAs for 17-β-estradiol and progesterone were performed during the late first trimester of pregnancy. Setting Academic institution. Subjects Women in the Spontaneous/Medically Assisted/Assisted Reproductive Technology cohort (N = 409), 208 of whom conceived spontaneously and 201 with infertility [non in vitro fertilization treatments (NIFT), n=90; in vitro fertilization (IVF), n=111]. Intervention Mode of conception. Main Outcome Measures Levels of of 806 metabolites within eight superpathways, 17-β-estradiol, and progesterone in maternal plasma in the late first trimester. Results Metabolomic differences in the lipid superpathway (i.e., steroid metabolites, lipids with docosahexaenoyl acyl chains, acyl cholines), and xanthine and benzoate metabolites (P < 0.05) were significant among the spontaneous and two infertility groups, with greatest differences between the spontaneous and IVF groups. 17-β-estradiol and progesterone levels were significantly elevated in the infertility groups, with greatest differences between the spontaneous and IVF groups. Conclusion Metabolomic profiles differ between spontaneous and infertility pregnancies, likely driven by IVF. Higher levels of steroids and their metabolites are likely due to increased hormone production from placenta reprogrammed from fertility treatments, which may contribute to adverse outcomes associated with infertility and the treatments used.

scholarly journals The role of bacterial biofilms in the development of chronic pathological processes in the vagina and endometrium

2016 ◽  
Vol 65 (4) ◽  
pp. 65-75 ◽  
Author(s):  
Kira V. Shalepo ◽  
Tatiana G. Mihailenko ◽  
Alevtina M. Savicheva
Keyword(s):  
Pregnancy Outcomes ◽  
Biofilm Formation ◽  
Anaerobic Bacteria ◽  
Bacterial Biofilms ◽  
Vitro Fertilization ◽  
Microbial Biofilms ◽  
Ascending Infection ◽  
Adverse Pregnancy

Microbial biofilms are a problem in many areas of medicine. When the vaginal ecological system is disturbed, well-structured polymicrobial biofilm, covering the vaginal epithelium and consisting of anaerobic bacteria, is formed, which may lead to the development of recurrent bacterial vaginosis. During an ascending infection and the development of chronic endometritis, bacterial biofilms are detected in the endometrium. Biofilms formed by bacteria residing in the urogenital tract of woman, may result in dysfunctions of the reproductive system, in-vitro fertilization failures, complications of pregnancy, adverse pregnancy outcomes. In the paper, literature data regarding causes of of biofilm formation, methods of detection and treatment of biofilm infections are reviewed.

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