Analytical Method Development and Validation of Solifenacin in Pharmaceutical Dosage Forms by RP-HPLC
Keyword(s):
A new, accurate, precise, and robust HPLC method was developed and validated for the determination of solifenacin in tablet dosage form. The chromatographic separation was achieved on an Inertsil ODS 3V C18 (150 mm × 4.6 mm, 5 μm) stationary phase maintained at ambient temperature with a mobile phase combination of monobasic potassium phosphate (pH 3.5) containing 0.1% triethylamine and methanol (gradient mode) at a flow rate of 1.5 mL/min, and the detection was carried out by using UV detector at 220 nm. The performance of the method was validated according to the present ICH guidelines.
2013 ◽
Vol 49
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pp. 359-366
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2020 ◽
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pp. 97-101
2020 ◽
Vol 11
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pp. 6227-6232
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pp. 209-212
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Vol 23
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pp. 992-1000
2019 ◽
Vol 12
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pp. 269-276