Glycyrrhizae RadixMethanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference

Glycyrrhizae Radixmodulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract fromGlycyrrhizae Radix(MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and conditioned place preference (CPP). A cohort of rats was treated with METH (1 mg/kg/day) for 6 consecutive days, subjected to 6 days of withdrawal, and then challenged with the same dose of METH to induce locomotor sensitization; during the withdrawal period, the rats were administered MEGR (60 or 180 mg/kg/day). A separate cohort of rats was treated with either METH or saline every other day for 6 days in METH-paired or saline-paired chambers, respectively, to induce CPP. These rats were also administered MEGR (180 mg/kg) prior to every METH or CPP expression test. Pretreatment with MEGR (60 and 180 mg/kg/day) attenuated the expression of METH-induced locomotor sensitization dose-dependently, and 180 mg/kg MEGR significantly inhibited the development and expression of METH-induced CPP. Furthermore, administration of a selective GABAb receptor antagonist (SCH50911) prior to MEGR treatment effectively blocked the inhibitory effects of MEGR on locomotor sensitization, but not CPP. These results suggest thatGlycyrrhizae Radixblocked repeated METH-induced behavioral changes via GABAb receptors.

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Inhibitory effects of paeonol on morphine-induced locomotor sensitization and conditioned place preference in mice

Archives of Pharmacal Research ◽

10.1007/bf02973913 ◽

2006 ◽

Vol 29 (10) ◽

pp. 904-910 ◽

Cited By ~ 8

Author(s):

Jae Soon Eun ◽

KiHwan Bae ◽

Yeo-Pyo Yun ◽

Jin-Tae Hong ◽

Han-Na Kwon ◽

...

Keyword(s):

Conditioned Place Preference ◽

Place Preference ◽

Locomotor Sensitization ◽

Inhibitory Effects

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Melatonin decreases cocaine-induced locomotor sensitization and cocaine-conditioned place preference in rats

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2020.09.027 ◽

2021 ◽

Vol 132 ◽

pp. 97-110

Author(s):

Susana Barbosa-Méndez ◽

Gilberto Pérez-Sánchez ◽

Enrique Becerril-Villanueva ◽

Alberto Salazar-Juárez

Keyword(s):

Conditioned Place Preference ◽

Place Preference ◽

Locomotor Sensitization

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Environmental Enrichment Attenuates Morphine-Induced Conditioned Place Preference and Locomotor Sensitization in Maternally Separated Rat Pups

Basic and Clinical Neuroscience Journal ◽

10.32598/bcn.9.4.241 ◽

2018 ◽

pp. 241-250 ◽

Cited By ~ 1

Author(s):

Soheyla Khalaji ◽

Imanollah Bigdeli ◽

Raheb Ghorbani ◽

Hossein Miladi-Gorji

Keyword(s):

Conditioned Place Preference ◽

Environmental Enrichment ◽

Place Preference ◽

Locomotor Sensitization ◽

Rat Pups

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Pre-exposure of adolescent mice to morphine results in stronger sensitization and reinstatement of conditioned place preference than pre-exposure to hydrocodone

Journal of Psychopharmacology ◽

10.1177/0269881120926675 ◽

2020 ◽

Vol 34 (7) ◽

pp. 771-777

Author(s):

Caitlin A Madison ◽

Paul J Wellman ◽

Shoshana Eitan

Keyword(s):

Conditioned Place Preference ◽

Severe Pain ◽

Opioid Use Disorder ◽

Place Preference ◽

High Rate ◽

Locomotor Sensitization ◽

Locomotor Response ◽

Opioid Use ◽

Drug Induced ◽

Extinction Rates

Background: Opioids are commonly prescribed to treat moderate-to-severe pain. However, their use can trigger the development of opioid use disorder. A major problem in treating opioid use disorder remains the high rate of relapse. Aim: The purpose of this study was to determine whether there are differences among opioids in their ability to trigger relapse after pre-exposure during adolescence. Methods: On postnatal day 33, mice were examined for the acute locomotor response to saline, morphine, or hydrocodone (5 mg/kg). They were administered with the corresponding opioid or saline during postnatal days 34–38 (20 mg/kg) and 40–44 (40 mg/kg). On postnatal day 45, they were recorded for the development of locomotor sensitization (5 mg/kg). Starting on postnatal day 55, mice were examined for the acquisition (1, 5, 10, 20, and 40 mg/kg), extinction, and drug-induced reinstatement (1, 2.5, and 5 mg/kg) of conditioned place preference. Results: There were no significant differences in the acute locomotor response to morphine and hydrocodone. Morphine induced significantly stronger locomotor sensitization as compared to hydrocodone. Pre-exposure to morphine, but not hydrocodone, sensitized the acquisition of conditioned place preference. There were no significant differences in extinction rates. Mice pre-exposed to morphine reinstate conditioned place preference after priming with a 1 mg/kg dose. In contrast, higher priming doses were required for reinstatement in all other experimental groups. Conclusions: Adolescent mice administered with morphine develop greater sensitization to its effects and subsequently reinstate conditioned place preference more readily than mice administered with hydrocodone. This suggests higher risk for relapse after pre-exposure to morphine during adolescence as compared to hydrocodone.

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