Tissue Doppler Velocities of the Right and Left Ventricles and Their Association With C-Reactive Protein and Homocysteine Levels in Behcet’s Disease

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet’s disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-γ(IFN-γ), interleukin-1β(IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α(TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-γand TNF-αwere significantly increased in patients with active uveitis associated to BD compared to controls (P<0.05). IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P<0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P<0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.

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Homocysteine May Involve in the Pathogenesis of Behcet's Disease by Inducing Inflammation

Mediators of Inflammation ◽

10.1155/2008/407972 ◽

2008 ◽

Vol 2008 ◽

pp. 1-9 ◽

Cited By ~ 9

Author(s):

Selda Pelin Kartal Durmazlar ◽

Ahmet Akgul ◽

Fatma Eskioglu

Keyword(s):

Behçet’S Disease ◽

Tumor Necrosis ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Clinical Manifestations ◽

Healthy Individuals ◽

C Reactive Protein ◽

Behcet's Disease ◽

Reactive Protein ◽

Erythrocyte Sedimentation

Objective. Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD.Methods. Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated with respect to activity and specific individual clinical manifestations of the disease.Results. Hcy levels were found significantly elevated in active BD when compared to inactive BD and healthy controls. Hcy levels were found to have high correlation with the number of active clinical manifestations increased. A significant positive correlation was found between serum Hcy and TNF- levels, CRP, and ESR. Hcy was found to be the best predictor of TNF- among other parameters.Conclusion. Hcy may involve in the pathogenesis of BD by inducing inflammation.

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Serum interleukin-6, procalcitonin and C-reactive protein levels in subjects with active Behcet's disease

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/j.1468-3083.2004.00907.x ◽

2004 ◽

Vol 18 (3) ◽

pp. 318-320 ◽

Cited By ~ 47

Author(s):

B Adam ◽

E Calikoglu

Keyword(s):

Behçet’S Disease ◽

Interleukin 6 ◽

Behcet’S Disease ◽

Behçet's Disease ◽

C Reactive Protein ◽

Behcet's Disease ◽

Protein Levels ◽

Reactive Protein

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Optic nerve perineuritis and retroperitoneal panniculitis: rare first presentations of Behçet’s disease

BMJ Case Reports ◽

10.1136/bcr-2021-243997 ◽

2021 ◽

Vol 14 (7) ◽

pp. e243997

Author(s):

Katsunobu Yoshioka ◽

Eiko Morita

Keyword(s):

Optic Nerve ◽

Eye Movement ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Leg Pain ◽

Warning Sign ◽

Behcet's Disease ◽

Eye Pain ◽

The Right

A 46-year-old woman was admitted to our hospital because of high fever and lumbago. CT revealed increase in density of fat tissue around the aorta, suggesting retroperitoneal panniculitis. The following day, she reported of leg pain, pain in the mouth, painful urination and right eye pain that was exacerbated by eye movement. We observed erythema nodosum, aphthous stomatitis and genital ulceration. Ophthalmologic examination revealed mild right optic disc oedema. Visual acuity was normal in both eyes. MRI with gadolinium infusion revealed enhancement around the right optic nerve, suggesting optic nerve perineuritis (ONP). A diagnosis of Behçet’s disease was made. She was treated with prednisolone and colchicine with a favourable response. A warning sign of ONP is eye pain that is exacerbated by eye movement. MRI with gadolinium infusion should be performed immediately in such cases to prevent vision-threatening sequelae.

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475 A rare cause of right ventricular mass

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.254 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

A Briosa ◽

A R Almeida ◽

A C Gomes ◽

A R Pereira ◽

A Marques ◽

...

Keyword(s):

Right Ventricular ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Large Mass ◽

Behcet's Disease ◽

Ventricular Mass ◽

Right Ventricular Mass ◽

History Of ◽

The Right

Abstract Introduction Intracardiac masses are always a challenging diagnosis, especially when it involves the right side of the heart. There are multiples etiologies that can be responsible for these masses, namely thrombosis, neoplasm or vegetations. Occasionally, these may be related to an autoimmune process not yet discovered. Case Report 17-year-old male, with a previous history of genital ulcers, medicated with penicillin with complete resolution of symptoms. In January 2019, he started an history of recurrent fever, associated with right anterior thoracalgia, weight loss and oral afthosis. He went to the emergency department several times, where he was medicated with antibiotic, with partial symptom relief. Three months later, he returned to medical attention due to an episode of abundant hemoptysis, followed by hematemesis and cough. At hospital admission, he was hemodynamically stable, tachycardic (100/min) and with occasional episodes of cough. Cardiac and pulmonary auscultation were unremarkable. Thoracic CT revealed the presence of pulmonary thromboembolism (PTE) and a large mass in the right ventricle (RV). It was performed an echocardiogram (echo) that confirmed the presence of a large mass in the RV (50x53mm) from which a projecting hypermobile mass appeared to prolapse into the right atrium. Taking into account the diagnosis of PTE and the presence of a right ventricular mass, the patient was hospitalized and started anticoagulation. The case was immediately discussed with cardiac surgery, that confirmed that there was no surgical indication. During hospitalization, there were no more episodes of hemoptysis or hematemesis.Consecutive echos were performed, that did not reveal a significant decrease in mass dimensions despite anticoagulation. Viral serologies and autoimmunity panel were all negative. Cardiac RMI was performed raising the suspicion of a possible mass covered with thrombus. After discussion with rheumatology, and according to clinical signs, the hypothesis of vasculitis was placed, and the patient started treatment with steroids. This treatment had to be suspended after a few days due to an infectious intercurrence. After a course of antibiotic therapy, the patient started therapy with cyclophosphamide with good clinical and echocardiographic response (reduced mass dimensions). It was admitted Behçet’s disease with cardiac complications, and the patient was referred to the rheumatology consultation. Conclusion Behçet’s disease is a multi-system, chronic disorder that behaves like vasculitis.There are some typical clinical manifestations associated with this disease, such as oral and genital afthosis, uveitis, arthritis, skin lesions and nervous system involvement.Presentations with cardiac symptoms are one of the extremely rare manifestations of this disease, posing a challenge for the treating physician. Abstract 475 Figure. Right ventricular mass

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Title: Predictive value of Erythrocyte Sedimentation Rate and C-Reactive Protein in Behcet's Disease Activity and Manifestations: A Cross-Sectional Study

10.21203/rs.3.rs-816619/v1 ◽

2021 ◽

Author(s):

Amirhossein Parsaei ◽

Soroush Moradi ◽

Maryam Masoumi ◽

Fereydoun Davatchi ◽

Anahita Najafi ◽

...

Keyword(s):

Disease Activity ◽

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Predictive Value ◽

Behcet’S Disease ◽

Behçet's Disease ◽

C Reactive Protein ◽

Behcet's Disease ◽

Reactive Protein ◽

Erythrocyte Sedimentation

Abstract Background: Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity.Methods: Participants (n=514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and specificity and the area under the curve (AUC) for each model were determined using receiver operating characteristic curves (ROC). Multiple regressions were run to predict BD activity score from ESR and CRP.Result: Patients with active ocular, oral, genital, joint and dermal manifestations had higher ESR and CRP values (Mann-Whitney U test, p< 0.05 for all). Binomial logistic regressions showed that ESR had valuable predictive value for active BD (OR =1.09[1.04-1.13] , AUC = 0.79[0.74-0.83], p<0.001) and active vascular manifestations (1.03[1.01-1.05], AUC = 0.85[0.79-0.92], p<0.001). CRP had good predictive value for active vascular manifestations (OR 1.98[1.45-2.72], AUC = 0.86[0.8-0.91], p<0.001,). The optimal value of ESR ≥ 10.5 and ESR ≥ 42.5 could predict active BD and active vascular manifestations with Sensitivity,Specificity = 71%,75% and =81%, 83% respectively.Conclusions: ESR and CRP are both associated with active BD and most manifestations of the diseases. They can be used for the prediction of active BD and active vascular manifestations in BD patients. Further studies can help to confirm the findings of the current research.

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