scholarly journals Acoustic Radiation Force Impulse Imaging: A New Tool for the Diagnosis of Papillary Thyroid Microcarcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Yi-Feng Zhang ◽  
Chang Liu ◽  
Hui-Xiong Xu ◽  
Jun-Mei Xu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diagnostic Performance ◽  
Thyroid Nodules ◽  
Acoustic Radiation Force Impulse ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma ◽  
Arfi Elastography ◽  
Independent Risk Factors ◽  
Arfi Imaging

Purpose. To evaluate the diagnostic performance of ARFI imaging in differentiating between benign and malignant thyroid nodules <1 cm.Materials and Methods. 173 pathologically proven thyroid nodules (77 benign, 96 malignant) in 157 patients were included in this study. Receiver-operating characteristic curve (ROC) analyses were performed to assess the diagnostic performance of conventional ultrasound (US) and ARFI imaging in papillary thyroid microcarcinoma (PTMC). The independent risk factors for predicting PTMC were evaluated.Results. The mean SWV value of benign and malignant thyroid nodules were 2.57 ± 0.79 m/s (range: 0.90–4.92 m/s) and 3.88 ± 2.24 m/s (range: 1.49–9.00 m/s) (P=0.000). Az for VTI elastography score was higher than that for hypoechoic, absence of halo sign, and type III vascularity (P<0.05). The optimal cut-offs for VTI elastography score and SWV were score 4 and 3.10 m/s. Gender, hypoechoic, taller than wide, VTI elastography score ≥ 4, and SWV > 3.10 m/s had been found to be independent risk factors for predicting PTMC.Conclusion. ARFI elastography can provide elasticity information of PTMC quantitatively (VTQ) and directly reflects the overall elastic properties (VTI). Gender, hypoechogenicity, taller than wide, VTI elastography score ≥ 4, and SWV > 3.10 m/s are independent risk factors for predicting PTMC. ARFI elastography seems to be a new tool for the diagnosis of PTMC.

scholarly journals Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma: A Single-Center Retrospective Study

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Feng Cheng ◽  
Yanyan Chen ◽  
Lei Zhu ◽  
Bin Zhou ◽  
Yonghong Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Multivariate Logistic Regression Analysis ◽  
Extrathyroidal Extension ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Thyroid Microcarcinoma ◽  
Independent Risk Factors

Objective. To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods. Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retrospectively analyzed. Clinical and pathological risk factors for lymph node metastasis (LNM), central lymph node metastasis (CLNM), and lateral lymph node metastasis (LLNM) were analyzed. Results. LNM was found in 236 (30.2%) patients. Multivariate logistic regression analysis revealed that in PTMC, male gender, age<55 years, tumor size>5 mm, bilateral lesions, and extrathyroidal extension were independent risk factors for LNM in general and for CLNM. For LLNM, tumor size>5 mm, multifocal lesions, and extrathyroidal extension were independent risk factors. Conclusions. Identification of risk factors for cervical LNM could assist individualization of clinical management for PTMC.

scholarly journals Risk Factors for Nodal Metastasis in cN0 Papillary Thyroid Microcarcinoma

2015 ◽  
Vol 16 (8) ◽  
pp. 3361-3363 ◽  
Author(s):  
Li-Yang Zhang ◽  
Zi-Wen Liu ◽  
Yue-Wu Liu ◽  
Wei-Sheng Gao ◽  
Chao-Ji Zheng
Keyword(s):  
Risk Factors ◽  
Nodal Metastasis ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

The Surgical Management of Papillary Thyroid Microcarcinoma: A 162-Month Single-Center Experience of 273 Cases

2012 ◽  
Vol 78 (11) ◽  
pp. 1215-1218 ◽  
Author(s):  
Qingqing He ◽  
Dayong Zhuang ◽  
Luming Zheng ◽  
Ziyi Fan ◽  
Peng Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Surgical Management ◽  
Lymph Node Metastases ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Neck Lymph Node ◽  
Lateral Node ◽  
Thyroid Microcarcinoma ◽  
Node Metastases

The aim of this study was to evaluate outcomes for patients with papillary thyroid microcarcinoma (PTMC) treated at a single institution during a 162-month period and to determine which patients need aggressive treatment. Two hundred seventy-three patients with PTMC had subtotal or total thyroidectomy 1 prophylactic or therapeutic lymph node dissection. Clinical and histopathological characteristics of 273 patients were identified and statistically analyzed. The tumors were multifocal in 36.3 per cent of the patients with PTMCs. Fifty-six per cent had neck lymph node metastases at diagnosis. Large-sized tumor (over 5 mm), age older than 45 years, multifocality, bilaterality, and extrathyroidal extension were associated with subclinical central lymph node metastases. Ninety-six patients older than 45 years of age were upgraded from Stage I to III or IVA. Ten patients with lateral node recurrence or local recurrence in the residual thyroid had one or more risk factors. The high rates of multifocality and Level VI area subclinical lymph node metastasis were two important clinical and histopathological characteristics of PTMC. Patients who had one or more risk factors should receive more aggressive surgical management.

Prevalence and Prediction for Malignancy of Additional Thyroid Nodules Coexisting with Proven Papillary Thyroid Microcarcinoma

2013 ◽  
Vol 149 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Sung Yong Choi ◽  
Seung Hoon Woo ◽  
Jung Hee Shin ◽  
Noorie Choi ◽  
Young-Ik Son ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

scholarly journals Diagnostic Efficacy of Ultrasound, Cytology, and BRAFV600E Mutation Analysis and Their Combined Use in Thyroid Nodule Screening for Papillary Thyroid Microcarcinoma

2022 ◽  
Vol 11 ◽  
Author(s):  
Jing Du ◽  
Ruijun Han ◽  
Cui Chen ◽  
Xiaowei Ma ◽  
Yuling Shen ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Roc Curve ◽  
Thyroid Nodules ◽  
Papillary Thyroid Microcarcinoma ◽  
Maximum Diameter ◽  
Diagnostic Efficiency ◽  
Papillary Thyroid ◽  
Diagnostic Efficacy ◽  
Thyroid Microcarcinoma ◽  
Combined Use

BackgroundUltrasound, cytology, and BRAFV600E mutation analysis were applied as valuable tools in the differential diagnosis of thyroid nodules. The aim of the present study was to evaluate the diagnostic efficiency of the three methods and their combined use in screening for papillary thyroid microcarcinoma (PTMC).MethodsA total of 1,081 patients with 1,157 thyroid nodules (0.5–1 cm in maximum diameter) classified as thyroid imaging reporting and data system (TIRADS) 4–5 were recruited. All patients underwent ultrasound, fine-needle aspiration (FNA) examination, and an additional BRAFV600E mutation test. TIRADS and Bethesda System for Reporting Thyroid Cytopathology (BSRTC) were adopted to judge the ultrasound and cytological results. The receiver operating characteristic (ROC) curve was established to assess the diagnostic values of different methods.ResultsOf the 1,157 nodules, 587 were benign and 570 were PTMCs. BRAFV600E mutation test had highest sensitivity (85.4%), specificity (97.1%), accuracy (91.4%), and area under the ROC curve (Az) value (0.913) among the three methods. The combination of BSRTC and BRAFV600E mutation analysis yielded a considerably high sensitivity (96.0%), accuracy (94.3%), and negative predictive value (95.9%) than either BSRTC or BRAFV600E mutation alone (P &lt; 0.0001 for all comparisons). Of all the methods, the combined use of the three methods produced the best diagnostic performance (Az = 0.967), which was significantly higher than that (Az = 0.943) for the combination of BSRTC and BRAFV600E mutation (P &lt; 0.0001). The diagnostic accuracy of the molecular method in the 121 nodules with indeterminate cytology was 90.1% (109/121), which was significantly higher than that of TIRADS classification, 74.4% (90/121) (P = 0.002).ConclusionThe combined use of ultrasound, cytology, and BRAFV600E mutation analysis is the most efficient and objective method for diagnosing PTMC. Both BRAFV600E mutation and TIRADS classification are potentially useful adjuncts to differentiate thyroid nodules, especially indeterminate samples classified as BSRTC III.

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