scholarly journals Perineural Spread of Salivary Duct Carcinoma to the Internal Auditory Canal

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Winfred Kitavi ◽  
Ulrich Hamberger ◽  
Holger Sudhoff
Keyword(s):  
Adjuvant Radiotherapy ◽  
Cerebellopontine Angle ◽  
Recurrent Disease ◽  
Malignant Tumors ◽  
Internal Auditory Canal ◽  
Salivary Duct ◽  
Perineural Spread ◽  
Duct Carcinoma ◽  
Surgical Measures ◽  
Total Parotidectomy

Salivary duct carcinomas (SDCs) are high-grade malignant tumors exhibiting aggressive growth with early regional and distant metastasis. We report a case of SDC in a 63-year-old male with early recurrent disease in the cerebellopontine angle (CPA) after total parotidectomy and adjuvant radiotherapy. The tendency of the tumor to recur or metastasize despite radical surgical measures and radiotherapy continues to pose a therapeutic challenge.

scholarly journals Salivary Duct Carcinoma: Case Reports and Brief Review of the Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Deepti Kantamani ◽  
Sai S. Bandaru ◽  
Jennifer L. Miatech ◽  
M. Patrick Stagg
Keyword(s):  
Neck Dissection ◽  
Adjuvant Radiotherapy ◽  
Case Reports ◽  
Salivary Duct Carcinoma ◽  
World Health ◽  
High Morbidity ◽  
Adjuvant Radiation ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Total Parotidectomy

Salivary duct carcinoma (SDC) is an uncommon and highly aggressive tumor associated with high morbidity and mortality. According to the World Health Organization, it is an extremely rare malignancy with an estimated incidence of 1-1.2 in 1,000,000 patients. Standard treatment for SDC is wide surgical resection along with lymph node dissection followed by adjuvant radiation therapy. The role of adjuvant chemotherapy is not known. In this report, we present three cases of SDC. A 71-year-old female with T1N0M0 disease was treated with total parotidectomy, ipsilateral neck dissection, and adjuvant radiotherapy without evidence of disease recurrence at 5 months. The second is a 59-year-old female with TXN1M0 disease who was treated with total parotidectomy with ipsilateral level I-IV neck dissection and adjuvant radiotherapy without evidence of disease occurrence at 21 months. The third case is a 79-year-old male with widely metastatic disease, including brain metastases, treated with cranial irradiation, leuprolide, and lapatinib who remains under home hospice care.

Management of sarcomatoid salivary duct carcinoma of the submandibular gland duct with coexisting seropositive human immunodeficiency virus

2013 ◽  
Vol 127 (6) ◽  
pp. 621-624
Author(s):  
W F Mourad ◽  
K S Hu ◽  
R A Shourbaji ◽  
L B Harrison
Keyword(s):  
Computed Tomography ◽  
Submandibular Gland ◽  
Adjuvant Radiotherapy ◽  
Salivary Duct Carcinoma ◽  
Emission Tomography ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Positron Emission ◽  
Immunodeficiency Virus ◽  
Gland Duct

AbstractBackground:Sarcomatoid salivary duct carcinoma of the submandibular gland is extremely rare. This paper highlights the impact of surgery and adjuvant radiation therapy on the outcome of this disease.Methods:A 59-year-old man with human immunodeficiency virus presented with a painless, rapidly growing left neck mass. Biopsy followed by surgical excision of the left submandibular gland revealed sarcomatoid salivary duct carcinoma of the submandibular gland duct with perineural invasion and close margins, for which he underwent adjuvant radiotherapy. Post-operative positron emission tomography and computed tomography revealed no residual or metastatic disease. Pathological analysis of tumour–node–metastasis staging revealed a T2 N0 M0 (stage II) tumour.Results:The patient tolerated his treatment without serious acute or long-term side effects. There was no evidence of disease on comprehensive examination or on positron emission tomography or computed tomography scans at the 4.6-year follow up.Conclusion:Surgery followed by adjuvant radiotherapy provided practical locoregional control with acceptable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.

scholarly journals Bone marrow metastases in salivary duct carcinoma of the parotid gland

2018 ◽  
Vol 11 (1) ◽  
pp. bcr-2018-226636
Author(s):  
Ameya Asarkar ◽  
Amol Takalkar ◽  
Manish Dhawan ◽  
Cherie Ann O Nathan
Keyword(s):  
Bone Marrow ◽  
Salivary Gland ◽  
Salivary Duct Carcinoma ◽  
Salivary Gland Cancer ◽  
Bone Marrow Metastasis ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Bone Marrow Metastases ◽  
High Index Of Suspicion ◽  
Total Parotidectomy

Salivary duct carcinoma (SDC) is a rare and extremely aggressive salivary gland cancer. An 81-year-old woman with SDC underwent a total parotidectomy with facial nerve sacrifice and a neck dissection. Following surgery, she was diagnosed with disseminated bone marrow metastases. She underwent chemotherapy and trastuzumab for palliation. We present a case of SDC of the parotid which was diagnosed with disseminated bone marrow metastasis following surgery for the primary. This case also highlights the importance of having a high index of suspicion while evaluating highly aggressive tumours like SDC for any atypical findings during workup.

The Importance of Adjuvant Radiotherapy in Treatment of Localised Salivary Duct Carcinoma

2011 ◽  
Vol 23 (3) ◽  
pp. S45-S46 ◽  
Author(s):  
F. McGrane ◽  
R.K. Shrimali ◽  
A.G. Robertson ◽  
C. Paterson ◽  
P.D. Correa
Keyword(s):  
Adjuvant Radiotherapy ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

Hepatocyte ultrastructural alterations in perimetastatic areas

1996 ◽  
Vol 54 ◽  
pp. 768-769
Author(s):  
H. J. Finol ◽  
M. E. Correa ◽  
L.A. Sosa ◽  
A. Márquez ◽  
N.L. Díaz
Keyword(s):  
Malignant Tumor ◽  
Malignant Tumors ◽  
Surrounding Tissue ◽  
Ultrastructural Changes ◽  
Pancreas Carcinoma ◽  
Duct Carcinoma ◽  
Tissue Samples ◽  
Primary Malignant Tumor ◽  
Transmission Electron ◽  
Remote Sites

In classical oncological literature two mechanisms for tissue aggression in patients with cancer have been described. The first is the progressive invasion, infiltration and destruction of tissues surrounding primary malignant tumor or their metastases; the other includes alterations produced in remote sites that are not directly affected by any focus of disease, the so called paraneoplastic phenomenon. The non-invaded tissue which surrounds a primary malignant tumor or its metastases has been usually considered a normal tissue . In this work we describe the ultrastructural changes observed in hepatocytes located next to metastases from diverse malignant tumors.Hepatic biopsies were obtained surgically in patients with different malignant tumors which metatastized in liver. Biopsies included tumor mass, the zone of macroscopic contact between the tumor and the surrounding tissue, and the tissue adjacent to the tumor but outside the macroscopic area of infiltration. The patients (n = 5), 36–75 years old, presented different tumors including rhabdomyosarcoma, leiomyosarcoma, pancreas carcinoma, biliar duct carcinoma and colon carcinoma. Tissue samples were processed with routine techniques for transmission electron microscopy and observed in a Hitachi H-500 electron microscope.

68-Gallium-PSMA-HBED-CC PET/CT imaging for recurrent/metastatic adenoid cystic carcinoma and salivary duct carcinoma

2019 ◽  
Author(s):  
W van Boxtel ◽  
S Lütje ◽  
AC van Engen-van Grunsven ◽  
GW Verhaegh ◽  
JA Schalken ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Ct Imaging ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Adenoid Cystic ◽  
Pet Ct

Microsurgical Treatment of Meningiomas of the Cerebellopontine Angle with Internal Auditory Canal Extension

Skull Base ◽  
2009 ◽  
Vol 19 (01) ◽  
Author(s):  
Martin Chovanec ◽  
Eduard Zverina ◽  
Jan Betka ◽  
Jiri Skrivan ◽  
Jan Kluh ◽  
...  
Keyword(s):  
Cerebellopontine Angle ◽  
Internal Auditory Canal ◽  
Microsurgical Treatment
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