scholarly journals Bipolar Disorder and Multiple Sclerosis: A Case Series

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Youssef Sidhom ◽  
Mouna Ben Djebara ◽  
Yosr Hizem ◽  
Istabrak Abdelkefi ◽  
Imen Kacem ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Bipolar Disorder ◽  
Interferon Beta ◽  
Psychiatric Symptoms ◽  
Treatment Options ◽  
Case Series ◽  
Psychotic Symptoms ◽  
Antipsychotic Treatment ◽  
High Dose ◽  
Psychiatric Disturbance

Background.The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options.Observations.All patients fulfilled the McDonald criteria for MS. Two patients were followed up in psychiatry for manic or depressive symptoms before developing MS. A third patient was diagnosed with MS and developed deferred psychotic symptoms. Some clinical and radiological features are highlighted in our patients: one manic episode induced by high dose corticosteroids and one case of a new orbitofrontal MRI lesion concomitant with the emergence of psychiatric symptoms. All patients needed antipsychotic treatment with almost good tolerance for high dose corticosteroids and interferon beta treatment.Conclusions.MRI lesions suggest the possible implication of local MS-related brain damage in development of pure “psychiatric fits” in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits.

scholarly journals Bipolar disorder and multiple sclerosis

2007 ◽  
Vol 65 (4b) ◽  
pp. 1177-1180 ◽  
Author(s):  
Mariana Inés Ybarra ◽  
Marcos Aurélio Moreira ◽  
Carolina Reis Araújo ◽  
Marco Aurélio Lana-Peixoto ◽  
Antonio Lucio Teixeira
Keyword(s):  
Multiple Sclerosis ◽  
Bipolar Disorder ◽  
Adverse Reaction ◽  
Mood Disorders ◽  
Psychiatric Symptoms ◽  
Biological Factors ◽  
Demyelinating Lesions

Bipolar disorder may be overrepresented in multiple sclerosis (MS) patients. Although research in this area is limited, studies assessing the nature of this association have focused on genetic aspects, adverse reaction to drugs and brain demyelinating lesions. Herein we report three patients with MS that also presented bipolar disorder. The coexistence of neurological and psychiatric symptoms in most MS relapses highlights the relevance of biological factors in the emergence of mood disorders in these patients.

Multiple sclerosis and psychiatric symptoms: a case series

2016 ◽  
Vol 26 ◽  
pp. S665-S666
Author(s):  
M.P. Calvo Rivera ◽  
L. Aguado Bailón ◽  
A. Porras Segovia ◽  
J. Cervilla Ballesteros
Keyword(s):  
Multiple Sclerosis ◽  
Psychiatric Symptoms ◽  
Case Series

scholarly journals A case of methamphetamine use disorder presenting a condition of ultra-rapid cycler bipolar disorder

2019 ◽  
Vol 7 ◽  
pp. 2050313X1982773
Author(s):  
Haruki Ikawa ◽  
Sho Kanata ◽  
Akihisa Akahane ◽  
Mamoru Tochigi ◽  
Naoki Hayashi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Mood Disorder ◽  
Depressive Mood ◽  
Mood Stabilizers ◽  
Psychotic Symptoms ◽  
High Dose ◽  
Distinctive Features ◽  
Methamphetamine Use ◽  
Induced Mood ◽  
Methamphetamine Use Disorder

Methamphetamine, a potent psychostimulant, may cause a condition of mood disorder among users. However, arguments concerning methamphetamine-induced mood disorder remain insufficient. This case study describes a male with methamphetamine-induced bipolar disorder not accompanied by psychotic symptoms, who twice in an 11-year treatment period, manifested an ultra-rapid cycler condition alternating between manic and depressive mood states with 3- to 7-day durations for each. The conditions ensued after a bout of high-dose methamphetamine use and shifted to a moderately depressive condition within 1 month after the use under a treatment regimen of aripiprazole and mood stabilizers. The cycler condition may be characteristic of a type of the bipolar disorder and a sign usable for characterization. Further efforts are needed to seek distinctive features and to improve diagnostic assessment of methamphetamine-induced mood disorders.

scholarly journals Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Muhammed Emin Özcan ◽  
Bahri İnce ◽  
Hasan Hüseyin Karadeli ◽  
Talip Asil
Keyword(s):  
Multiple Sclerosis ◽  
Demyelinating Disease ◽  
Psychiatric Symptoms ◽  
Short Interval ◽  
Complete Response ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
Sudden Onset ◽  
Psychotic Symptoms ◽  
Not Otherwise Specified ◽  
The Central Nervous System

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Psychiatric symptoms are not infrequent during MS, yet onset of MS with psychosis is rarely encountered. A 27-year-old Caucasian male was admitted due to numbness in his right arm and difficulty in walking. His clinical and laboratorial exams lead to the MS diagnosis. Nine months earlier, he also developed psychotic disorder, not otherwise specified (PD-NOS). His sudden onset of PD-NOS, his rapid and complete response to antipsychotics, and a relatively short interval between psychiatric and neurological signs indicate a high likelihood that PD-NOS was a manifestation of underlying MS. He also suffers from hypertrophic obstructive cardiomyopathy (HOCM). The patient’s neurological complaints were recovered with methylprednisolone (1 g/day, i.v.) given for five days. Glatiramer acetate (1 × 1 tb.s.c.) was prescribed for consolidation and, after nine months of his admission, the patient fully recovered from neurological and psychiatric complaints. Interestingly, very recent studies indicate specific alpha-actinin antibodies in MS and alpha-actinin mutations cause HOCM. Thus, concurrence of MS with HOCM can be even a new syndrome, if further genetic studies prove.

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