Potential Use ofC60/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer

The photosensitizing ability of C60/2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) nanoparticles under visible light irradiation was studied by electron spin resonance (ESR) and phototoxicity on cancer cells. In addition, the photoinduced antitumor effect to the tumor-bearing mice was evaluated. C60nanoparticles were prepared by grinding a mixture of HP-β-CyD. The resulting C60/HP-β-CyD nanoparticles were highly-sensitive to visible light and generated higher levels of1O2than protoporphyrin IX (PpIX). C60/HP-β-CyD reduced the viability of cancer cells (HeLa cells and A549 cells) in response to irradiation by visible light in a dose-dependent manner. The IC50values of the C60/HP-β-CyD nanoparticles was 10 μM for HeLa cells and 60 μM for A549 cells at an irradiation level of 35 mW/cm2. The photodynamic effect of C60/HP-β-CyD nanoparticles on thein vivogrowth of mouse sarcoma S-180 cells was evaluated after intratumor injection. The outcome of PDT by C60/HP-β-CyD was directly dependent on the dose of irradiated light. Treatment with C60/HP-β-CyD nanoparticles at a C60dose of 2.0 mg/kg under visible light irradiation at 350 mW/cm2(63 J/cm2) markedly suppressed tumor growth, whereas that at 30 J/cm2was less effective. These findings suggest that C60/HP-β-CyD nanoparticles represent a promising candidate for use in cancer treatment by PDT.

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Effects of Visible-Light Irradiation of Protoporphyrin IX on the Self-Assembly of Tubulin Heterodimers

ChemPhysChem ◽

10.1002/cphc.201600629 ◽

2016 ◽

Vol 17 (20) ◽

pp. 3269-3282

Author(s):

Alicia Vall-Sagarra ◽

Brady McMicken ◽

Santi Nonell ◽

Lorenzo Brancaleon

Keyword(s):

Visible Light ◽

Visible Light Irradiation ◽

Self Assembly ◽

Protoporphyrin Ix ◽

The Self ◽

Light Irradiation

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Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

Journal of Materials Chemistry B ◽

10.1039/c6tb03230c ◽

2017 ◽

Vol 5 (9) ◽

pp. 1815-1821 ◽

Cited By ~ 40

Author(s):

Daniel Bůžek ◽

Jaroslav Zelenka ◽

Pavel Ulbrich ◽

Tomáš Ruml ◽

Ivana Křížová ◽

...

Keyword(s):

Photodynamic Therapy ◽

Visible Light ◽

Cancer Cells ◽

Visible Light Irradiation ◽

Metal Organic Frameworks ◽

Delivery Systems ◽

Post Treatment ◽

Light Irradiation ◽

Attractive Feature ◽

Metal Organic

PCN-222/MOF-545 nanoparticles cause apoptosis of cancer cells upon visible light irradiation. The phototoxicity of the nanoparticles is deactivated after several hours, which is an attractive feature to avoid post-treatment photosensitization issues.

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Comparison of the killing effects between nitrogen-doped and pure TiO2 on HeLa cells with visible light irradiation

Nanoscale Research Letters ◽

10.1186/1556-276x-8-96 ◽

2013 ◽

Vol 8 (1) ◽

pp. 96 ◽

Cited By ~ 19

Author(s):

Zheng Li ◽

Xiaobo Pan ◽

Tianlong Wang ◽

Pei-Nan Wang ◽

Ji-Yao Chen ◽

...

Keyword(s):

Visible Light ◽

Visible Light Irradiation ◽

Hela Cells ◽

Pure Tio2 ◽

Light Irradiation ◽

Nitrogen Doped

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Berbamine Inhibits Cell Proliferation, Migration, and Invasion and Induces Cell Apoptosis of A549 Cells Via Regulating C-Maf, PI3K/Akt and MDM2-P53 Pathways

10.21203/rs.3.rs-90754/v1 ◽

2020 ◽

Author(s):

Lili Liu ◽

Zhiying Xu ◽

Binbin Yu ◽

Li Tao ◽

Ying Cao

Keyword(s):

Cancer Cells ◽

A549 Cells ◽

Migration And Invasion ◽

Dependent Manner ◽

Transwell Assay ◽

Scratch Assay ◽

Western Blotting Assay ◽

Wound Scratch Assay

Abstract Background To investigate the influences of berbamine (BBM) on the cell viability, proliferation, and migration of A549 cells in vitro and in vivo, and explore the possible mechanisms.MethodsAfter the A549 cells were treated with BBM, the cell viability and proliferation of the cancer cells were detected by MTT assay, EdU assay, and colony formation assay. Migration and invasion of cancer cells were illustrated through wound scratch assay and transwell assay. Apoptosis of cancer cells was evaluated by trypan blue dye exclusion assay and elisa assay. Beside, the expression of PI3K/Akt signal pathway-related proteins and c-Maf were detected employing western blotting assay. Xenografted model of NSCLC was used to detect the effect of BBM on tumor growth and metastasis in vivo.ResultsMTT assay showed that BBM inhibited the viability of A549 cells in a concentration-dependent manner and time-dependent manner. The results from the colony formation assay and EdU assay revealed that BBM (10 µM) could significantly inhibit the proliferation of A549 cells (P＜0.001). And BBM (10 µM) significantly inhibited the migration and invasion in the wound scratch assay and transwell assay (P＜0.05). Trypan blue assay and elisa assay indicated that BBM (20 µM) significantly induced apoptosis of A549 cells. The nude mice assay manifested the tumor volume was significantly shrank by BBM (20 mg/kg) (P＜0.05). Western blotting assay showed that the PI3K/Akt and MDM2-p53 signaling pathways were inhibited by BBM, and the expression of c-Maf was downregulated by BBM. ConclusionsBBM could inhibit the proliferation and metastasis, and induce apoptosis of A549 cells in vitro and in vivo, these effects may be achieved by reducing the expression of c-Maf and regulating the PI3K/Akt and MDM2-p53 pathways.

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Cu Doped TiO2: Visible Light Assisted Photocatalytic Antimicrobial Activity and High Temperature Anatase Stability

10.26434/chemrxiv.7159733.v1 ◽

2018 ◽

Cited By ~ 2

Author(s):

Snehamol Mathew ◽

Priyanka Ganguly ◽

Stephen Rhatigan ◽

Vignesh Kumaravel ◽

Ciara Byrne ◽

...

Keyword(s):

Visible Light ◽

Visible Light Irradiation ◽

Density Functional ◽

Anatase Phase ◽

Sol Gel ◽

Chemical Properties ◽

Light Irradiation ◽

Health Concern ◽

Bacterial Inactivation ◽

X Ray

Indoor surface contamination by microbes is a major public health concern. A damp environment is one potential sources for microbe proliferation. Smart photocatalytic coatings on building surfaces using semiconductors like titania (TiO2) can effectively curb this growing threat. Metal-doped titania in anatase phase has been proved as a promising candidate for energy and environmental applications. In this present work, the antimicrobial efficacy of copper (Cu) doped TiO2 (Cu-TiO2) was evaluated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) under visible light irradiation. Doping of a minute fraction of Cu (0.5 mol %) in TiO2 was carried out via sol-gel technique. Cu-TiO2 further calcined at various temperatures (in the range of 500 °C – 700 °C) to evaluate the thermal stability of TiO2 anatase phase. The physico-chemical properties of the samples were characterised through X-ray diffraction (XRD), Raman spectroscopy, X-ray photo-electron spectroscopy (XPS) and UV-visible spectroscopy techniques. XRD results revealed that the anatase phase of TiO2 was maintained well, up to 650 °C, by the Cu dopant. UV-DRS results suggested that the visible light absorption property of Cu-TiO2 was enhanced and the band gap is reduced to 2.8 eV. Density functional theory (DFT) studies emphasises the introduction of Cu+ and Cu2+ ions by replacing Ti4+ ions in the TiO2 lattice, creating oxygen vacancies. These further promoted the photocatalytic efficiency. A significantly high bacterial inactivation (99.9%) was attained in 30 mins of visible light irradiation by Cu-TiO2.

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Photo-Fenton Degradation of RhB over Nano-fibre Iron Oxides Interacted Montmorillonite under Visible Light Irradiation

CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) ◽

10.3724/sp.j.1088.2012.20756 ◽

2013 ◽

Vol 33 (10) ◽

pp. 1736-1741

Author(s):

Shilong ZHANG ◽

Xiaoming HU ◽

Xiaowei WANG ◽

Shijing LIANG ◽

Ling WU

Keyword(s):

Visible Light ◽

Iron Oxides ◽

Visible Light Irradiation ◽

Light Irradiation

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Semiconductor Photocatalysts for Solar-to-Hydrogen Energy Conversion: Recent Advances of CdS

Current Analytical Chemistry ◽

10.2174/1573411016666200106103712 ◽

2020 ◽

Vol 16 ◽

Author(s):

Yuxue Wei ◽

Honglin Qin ◽

Jinxin Deng ◽

Xiaomeng Cheng ◽

Mengdie Cai ◽

...

Keyword(s):

Hydrogen Production ◽

Visible Light ◽

Hydrogen Evolution ◽

Water Splitting ◽

Visible Light Irradiation ◽

Noble Metals ◽

Light Irradiation ◽

Photocatalytic Hydrogen Evolution ◽

Theoretical Design ◽

Recent Developments

Introduction: Solar-driven photocatalytic hydrogen production from water splitting is one of the most promising solutions to satisfy the increasing demands of a rapidly developing society. CdS has emerged as a representative semiconductor photocatalyst due to its suitable band gap and band position. However, the poor stability and rapid charge recombination of CdS restrict its application for hydrogen production. The strategy of using a cocatalyst is typically recognized as an effective approach for improving the activity, stability, and selectivity of photocatalysts. In this review, recent developments in CdS cocatalysts for hydrogen production from water splitting under visible-light irradiation are summarized. In particular, the factors affecting the photocatalytic performance and new cocatalyst design, as well as the general classification of cocatalysts, are discussed, which includes a single cocatalyst containing noble-metal cocatalysts, non-noble metals, metal-complex cocatalysts, metal-free cocatalysts, and multi-cocatalysts. Finally, future opportunities and challenges with respect to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen evolution are described. Background: Photocatalytic hydrogen evolution from water splitting using photocatalyst semiconductors is one of the most promising solutions to satisfy the increasing demands of a rapidly developing society. CdS has emerged as a representative semiconductor photocatalyst due to its suitable band gap and band position. However, the poor stability and rapid charge recombination of CdS restrict its application for hydrogen production. The strategy of using a cocatalyst is typically recognized as an effective approach for improving the activity, stability, and selectivity of photocatalysts. Methods: This review summarizes the recent developments in CdS cocatalysts for hydrogen production from water splitting under visible-light irradiation. Results: Recent developments in CdS cocatalysts for hydrogen production from water splitting under visible-light irradiation are summarized. The factors affecting the photocatalytic performance and new cocatalyst design, as well as the general classification of cocatalysts, are discussed, which includes a single cocatalyst containing noble-metal cocatalysts, non-noble metals, metal-complex cocatalysts, metal-free cocatalysts, and multi-cocatalysts. Finally, future opportunities and challenges with respect to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen evolution are described. Conclusion: The state-of-the-art CdS for producing hydrogen from photocatalytic water splitting under visible light is discussed. The future opportunities and challenges with respect to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen evolution are also described.

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