EMMPRIN Expression in Oral Squamous Cell Carcinomas: Correlation with Tumor Proliferation and Patient Survival

The aim of our study was to explore the clinicopathological and prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) expression in oral squamous cell carcinomas (OSCC), and its relation with the proliferative tumor status of OSCC. We examined EMMPRIN and Ki-67 proteins expression by immunohistochemistry in 74 cases with OSCC. Statistical analysis was conducted to examine their clinicopathological and prognostic significance in OSCC. EMMPRIN membrane expression was observed in all cases, with both membrane and cytoplasmic tumor expression in 61 cases (82.4%). EMMPRIN overexpression was observed in 56 cases (75.7%). Moderately or poorly differentiated tumors showed EMMPRIN overexpression more frequently than well-differentiated tumors(P=0.002). Overexpression of EMMPRIN was correlated with high Ki-67 expression(P=0.004). In the multivariate analysis, EMMPRIN overexpression reveals an adverse independent prognostic value for cancer-specific survival (CSS)(P=0.034). Our results reveal that EMMPRIN protein is overexpressed in more than two-thirds of OSCC cases, especially in high proliferative and less differentiated tumors. The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC. Moreover, the high expression of EMMPRIN makes it a possible therapeutic target in OSCC patients.

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Prognostic significance of VEGF-C, semaphorin 3F, and neuropilin-2 expression in oral squamous cell carcinomas and their relationship with lymphangiogenesis

Journal of Surgical Oncology ◽

10.1002/jso.23842 ◽

2014 ◽

Vol 111 (4) ◽

pp. 382-388 ◽

Cited By ~ 17

Author(s):

Bing Zhang ◽

Zhongxiuzi Gao ◽

Miao Sun ◽

Haixia Li ◽

Haixia Fan ◽

...

Keyword(s):

Squamous Cell ◽

Prognostic Significance ◽

Squamous Cell Carcinomas ◽

Oral Squamous Cell Carcinomas ◽

Semaphorin 3F

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Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas

Oral Oncology ◽

10.1016/j.oraloncology.2015.11.001 ◽

2016 ◽

Vol 52 ◽

pp. 75-84 ◽

Cited By ~ 32

Author(s):

Manuel Weber ◽

Christos Iliopoulos ◽

Patrick Moebius ◽

Maike Büttner-Herold ◽

Kerstin Amann ◽

...

Keyword(s):

Squamous Cell ◽

Early Stage ◽

Macrophage Polarization ◽

Prognostic Significance ◽

Squamous Cell Carcinomas ◽

Oral Squamous Cell Carcinomas

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Prognostic significance of DNA ploidy in oral squamous cell carcinomas

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/s1079-2104(05)80077-0 ◽

1995 ◽

Vol 79 (1) ◽

pp. 68-76 ◽

Cited By ~ 26

Author(s):

G. Baretton ◽

Xun Li ◽

C. Stoll ◽

E. Fischer-Brandies ◽

M. Schmidt ◽

...

Keyword(s):

Squamous Cell ◽

Dna Ploidy ◽

Prognostic Significance ◽

Squamous Cell Carcinomas ◽

Oral Squamous Cell Carcinomas

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Prognostic significance of fascin and Wilm’s tumor 1 (WT1) in oral squamous cell carcinomas – case control study

Egyptian Dental Journal ◽

10.21608/edj.2018.77007 ◽

2018 ◽

Vol 64 (2) ◽

pp. 1187-1202

Author(s):

Samah El-Meadawy ◽

Naglaa Salama ◽

Lobna Radwan ◽

Mahmoud El-sherbiny

Keyword(s):

Squamous Cell ◽

Case Control Study ◽

Prognostic Significance ◽

Case Control ◽

Squamous Cell Carcinomas ◽

Oral Squamous Cell Carcinomas ◽

Wilm's Tumor ◽

Wilm’S Tumor ◽

Wilm’S Tumor 1 ◽

Control Study

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The Expression and Biological Function of DKK1 in Oral Squamous Cell Carcinomas by Bioinformatics Analysis

10.21203/rs.3.rs-68871/v1 ◽

2020 ◽

Author(s):

Huijie Yu ◽

Tianhua Li ◽

Xuemei Mao

Keyword(s):

Squamous Cell ◽

Bioinformatics Analysis ◽

Prognostic Significance ◽

Squamous Cell Carcinomas ◽

Oral Squamous Cell Carcinomas ◽

Dkk1 Expression ◽

Mrna And Protein Expression ◽

Proliferation Ability ◽

Dickkopf 1

Abstract Background To investigate the expression of transcription factor Dickkopf-1 (DKK1) in oral squamous cell carcinomas (OSCC) by bioinformatics analysis and to clarify the connection between expression of DKK1 and clinicopathological features of OSCC, so as to elucidate the early diagnosis and prognostic significance of OSCC by DKK1. Methods This study used the GEPIA database in conjunction with the TCGA database to analyze the expression level of DKK1 in OSCC tissues and then verify it by QRTPCR and Western-blot analysis in vitro. The LinkedOmics database was used to describe the correlation between DKK1 expression and clinical pathological parameters of OSCC and its impact on prognosis. DKK1 was knocked down by RNA interference approach in SCC-4 and SCC-25 OSCC cell lines. In addition, the proliferation ability was assessed by MTT assay. Results DKK1 was highly expressed in OSCC and positively correlated with OSCC pathological grade and T stage. The results of TCGA showed that high DKK1 mRNA expression was associated with overall survival in OSCC. Besides, both DKK1 mRNA and protein expression was confirmed increased significantly in oral squamous cell carcinomas SCC-25 and SCC-4. Furthermore, MTT analysis investigated that knockdown of DKK1 caused reduced proliferation ability of OSCC cells. Conclusions The TCGA database analysis found that DKK1 is highly expressed in OSCC and is associated with multiple pathological indicators of OSCC, which will provide important theoretical guidance for subsequent oral squamous cell carcinoma research.

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Immunohistochemical Expression of Fatty acid Synthase, Ki-67 and p53 in Squamous Cell Carcinomas of the Larynx

The International Journal of Biological Markers ◽

10.1177/172460080802300307 ◽

2008 ◽

Vol 23 (3) ◽

pp. 176-181 ◽

Cited By ~ 3

Author(s):

M. De Vincentiis ◽

P. Di Cello ◽

F. Censi ◽

M. Leopizzi ◽

S. Natalizi ◽

...

Keyword(s):

Fatty Acid ◽

Squamous Cell ◽

Fatty Acid Synthase ◽

Prognostic Indicator ◽

Squamous Cell Carcinomas ◽

Immunohistochemical Expression ◽

Ki 67 ◽

Energy Needs ◽

Laryngeal Carcinomas ◽

Poorly Differentiated

Fatty acid synthase (FAS) is a recently discovered molecule involved in the energy supply to normal cells. FAS is overexpressed in neoplastic tissues because of their increased energy needs. We explored the immunohistochemical expression of FAS, Ki-67 and p53 in squamous cell carcinomas (SCC) of the larynx and their association with clinicopathological features and outcome. Specimens from 43 patients with SCC were evaluated. Statistical analysis revealed an association between poorly differentiated laryngeal carcinomas and FAS expression (p<0.005) and between FAS and Ki-67 overexpression (p<0.001). Finally, FAS expression was associated with overall survival (p<0.001). We suggest that FAS is a powerful prognostic indicator whose strength can be enhanced when it is evaluated together with clinicopathological data and Ki-67 expression.

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